MEDICATIONS EFFECT ON TASTE AND SMELL IN HIV

药物对艾滋病毒味觉和嗅觉的影响

• 批准号: 2458550
• 负责人: SUSAN S SCHIFFMAN
• 金额: $ 34.7万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2458550
• 关键词: AIDS; Candida albicans; Cryptococcus neoformans; Mycobacterium avium; Pneumocystis carinii; Toxoplasma gondii; antiAIDS agent; antifungal agents; antiprotozoal agents; antiviral agents; clinical research; cytomegalovirus; drug adverse effect; human immunodeficiency virus; human subject; olfactions; opportunistic infections; taste; tongue; topical drug application

DESCRIPTION (adapted from the Abstract): The purpose of this research is to determine the effect of medications used by HIV-infected patients on the senses of taste and smell. Significant losses in taste and smell perception occur in HIV infection, and these losses may contribute to inadequate food intake leading to malnutrition, weight loss, and ultimately wasting. Both experimental data and clinical reports indicate that medications play a major role in taste and olfactory losses. Clinical observations are helpful in determining potential chemosensory side effects of drugs; however, quantitative experimental studies are necessary to obtain scientifically accurate data on chemosensory losses resulting from use of pharmaceutical compounds. The Investigator and her associates will perform two projects. In Project I they will assess the effect of drugs on taste perception at the periphery by topical application of the pharmaceutical compounds to the tongue of asymptomatic HIV-infected persons and matched uninfected controls. (These studies are mandated because drugs are secreted into the saliva at concentrations that can modify taste transduction.) In Project II they will evaluate the effect of systemic use of medications on taste and smell perception in early HIV.

描述（根据摘要改编）：这项研究的目的是 确定艾滋病毒感染患者使用的药物对 感觉和气味的感觉。 口味和气味感知的重大损失 发生在艾滋病毒感染中，这些损失可能导致食物不足 摄入导致营养不良，减肥和最终浪费。 两个都 实验数据和临床报告表明，药物的作用 在口味和嗅觉损失中的主要作用。 临床观察很有帮助 在确定药物的潜在化学体积副作用时；然而， 定量实验研究是必要的，以科学地获得 使用药物的化学感应损失的准确数据 化合物。 调查员和她的同事将执行两个项目。 在项目中，他们将评估药物对味觉感知的影响 通过局部应用药物化合物的外围 无症状的艾滋病毒感染者和未感染的对照的舌头。 （这些研究之所以要求，是因为药物分泌到唾液中 可以改变口味转导的浓度。）在项目II中，他们将 评估全身使用药物对味觉和气味的影响 早期艾滋病毒的感知。