Africa Center for Biostatistical Excellence: Expanding biostatistical leadership for HIV/AIDS and TB Research

非洲生物统计卓越中心：扩大生物统计对艾滋病毒/艾滋病和结核病研究的领导作用

• 批准号: 10594528
• 负责人: Rhoderick Machekano
• 金额: $ 29.94万
• 依托单位: STELLENBOSCH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-19 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10594528
• 关键词: 2019-nCoV; Address; Africa; Africa South of the Sahara; Area; Biometry; COVID-19; COVID-19 impact; Caring; Data; Development; Disease; E-learning; Educational Status; Educational process of instructing; Evaluation; Faculty; Future; Grant; HIV; HIV/AIDS; Health; Health Sciences; Healthcare Systems; Infection; Infrastructure; Institution; International; Lead; Leadership; Medicine; Persons; Research; Research Activity; Research Design; Research Methodology; Research Project Grants; Research Training; South Africa; Students; Supervision; Targeted Research; Training; Training Programs; Universities; Virus; academic program; burden of illness; care delivery; data management; low and middle-income countries; novel; programs; response; treatment program

PROJECT SUMMARY LMIC: South Africa Institution: Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town Scientific Area: Biostatistics for HIV/AIDS and TB research design and methodology Africa Center for Biostatistical Excellence: expanding biostatistical leadership for HIV/AIDS and TB research This application is in response to the FOA “Fogarty HIV Research Training Program for Low- and Middle- Income Country Institutions” under the D43 grant mechanism (FOA PAR-19-283) and requests 5 years of support to expand biostatistics leadership for HIV research design and methodology at Stellenbosch University in South Africa. HIV/AIDS and TB remain the highest contributors to the burden of disease in sub-Saharan Africa (SSA). The COVID-19 disease resulting from infection with the novel SARS-CoV-2 virus poses a threat to the fragile healthcare system and infrastructure in SSA. In particular, COVID-19 effects on the delivery of care to people living with HIV/AIDS is likely to reverse gains in care and treatment programs achieved over decades. Data driven solutions and targeted research and evaluations demand complimentary teams of leaders, including biostatisticians. There is a huge deficit of doctoral level biostatisticians in the region. In 2017, we successfully implemented a masters’ level training program in biostatistics for HIV/AIDS research. Despite shortage in local biostatisticians with advanced training, we mobilized international collaborators to assist with teaching and student supervision. For sustainability of our training program, the natural progression is to train local future leaders in biostatistics who will continue the training initiatives and also provide research leadership to address the myriad of health problems in SSA. We propose to continue our efforts to bridge the gap in biostatistics capacity in SSA and develop research leadership at Stellenbosch University and the region at large. The specific objectives of this renewal of the training grant are to: (1) develop biostatistics leadership through a doctoral training program at Stellenbosch University; (2) continue building biostatistics capacity through a Masters’ level academic program and expand our reach using e-learning platforms; (3) consolidate the ACBE as a leader in providing professional development in biostatistics and data management to support HIV/AIDS research projects and programs within the SSA region and lead HIV/AIDS and TB research activities.

项目概要 中低收入国家：南非 机构：开普敦斯泰伦博斯大学医学与健康科学学院 科学领域：艾滋病毒/艾滋病和结核病的生物统计学研究设计和方法 非洲生物统计卓越中心：扩大艾滋病毒/艾滋病和艾滋病毒/艾滋病生物统计领导力 结核病研究 此应用程序是为了响应 FOA“福加蒂中低收入人群艾滋病毒研究培训计划” D43 拨款机制 (FOA PAR-19-283) 下的“收入国家机构”并要求 5 年 支持扩大斯泰伦博斯大学在艾滋病毒研究设计和方法方面的生物统计学领导地位 在南非。 艾滋病毒/艾滋病和结核病仍然是撒哈拉以南非洲地区疾病负担的最大来源。 由新型 SARS-CoV-2 病毒感染引起的 COVID-19 疾病对脆弱人群构成威胁 特别是 SSA 的医疗保健系统和基础设施，COVID-19 对向人们提供护理的影响。 感染艾滋病毒/艾滋病可能会逆转数十年来护理和治疗计划所取得的成果。 驱动的解决方案和有针对性的研究和评估需要互补的领导团队，包括 该地区博士级生物统计学家严重短缺。 2017年，我们成功实施了艾滋病毒/艾滋病研究生物统计学硕士学位培训项目。 尽管缺乏受过高级培训的当地生物统计学家，我们还是动员了国际合作者 协助教学和学生监督，以确保我们培训计划的可持续性。 进展是培训当地未来的生物统计学领导者，他们将继续开展培训活动，并且 提供研究领导力来解决 SSA 的无数健康问题。 我们建议继续努力弥合 SSA 生物统计能力的差距并开展研究 斯泰伦博斯大学和整个地区的领导力更新的具体目标。 培训补助金旨在：(1) 通过斯泰伦博斯的博士培训计划培养生物统计学领导力 大学；(2) 通过硕士水平的学术课程继续建设生物统计学能力并扩大 我们利用电子学习平台的影响力；(3) 巩固 ACBE 在提供专业知识方面的领导者地位； 发展生物统计学和数据管理以支持艾滋病毒/艾滋病研究项目和计划 在 SSA 地区领导艾滋病毒/艾滋病和结核病研究活动。

项目成果

Viral load care of HIV-1 infected children and adolescents: A longitudinal study in rural Zimbabwe.

HIV-1 感染儿童和青少年的病毒载量护理：津巴布韦农村地区的一项纵向研究。

• 发表时间: 2021
• 影响因子: 3.7
• 作者: Mapangisana, Tichaona;Machekano, Rhoderick;Kouamou, Vinie;Maposhere, Caroline;McCarty, Kathy;Mudzana, Marceline;Munyati, Shungu;Mutsvangwa, Junior;Manasa, Justen;Shamu, Tinei;Bogoshi, Mampedi;Israelski, Dennis;Katzenstein, David
• 通讯作者: Katzenstein, David

The Africa Center for Biostatistical Excellence: a proposal for enhancing biostatistics capacity for sub-Saharan Africa.

非洲生物统计卓越中心：关于增强撒哈拉以南非洲生物统计能力的提案。

• 发表时间: 2015-11-30
• 影响因子: 2
• 作者: Machekano, Rhoderick;Young, Taryn;Rusakaniko, Simbarashe;Musonda, Patrick;Sartorius, Ben;Todd, Jim;Fegan, Greg;Thabane, Lehana;Chikte, Usuf
• 通讯作者: Chikte, Usuf

Building capacity for network meta-analysis in Sub-Saharan Africa: reflections and future direction.

撒哈拉以南非洲网络元分析能力建设：反思和未来方向。

• 发表时间: 2024-01-02
• 影响因子: 3.7
• 作者: Rohwer, Anke;Ngah, Veranyuy;Mavridis, Dimitris;Young, Taryn;McCaul, Michael
• 通讯作者: McCaul, Michael

Advancing collaborations in health research and clinical trials in Sub-Saharan Africa: development and implementation of a biostatistical collaboration module in the Masters in Biostatistics Program at Stellenbosch University.

推进撒哈拉以南非洲地区健康研究和临床试验的合作：在斯泰伦博斯大学生物统计学硕士项目中开发和实施生物统计合作模块。

• 发表时间: 2021-07-22
• 影响因子: 2.5
• 作者: Esterhuizen, Tonya M;Li, Guowei;Young, Taryn;Zeng, Jie;Machekano, Rhoderick;Thabane, Lehana
• 通讯作者: Thabane, Lehana

Machine learning algorithms for predicting determinants of COVID-19 mortality in South Africa.

用于预测南非 COVID-19 死亡率决定因素的机器学习算法。

• 发表时间: 2023
• 作者: Chimbunde, Emmanuel;Sigwadhi, Lovemore N;Tamuzi, Jacques L;Okango, Elphas L;Daramola, Olawande;Ngah, Veranyuy D;Nyasulu, Peter S
• 通讯作者: Nyasulu, Peter S