Immunology Core

免疫学核心

• 批准号: 10595569
• 负责人: SCOTT D GRAY-OWEN
• 金额: $ 41.48万
• 依托单位: GEORGIA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-25 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10595569
• 关键词: Antigen Targeting; Antigens; Bacteria; Bacterial Adhesins; Bacterial Attachment Site; Base Sequence; Binding Proteins; Bioinformatics; Blood; Cells; Complement; Complement Factor H; Core Protein; Data; Data Protection; Detection; Development; Disease; Engineering; Enzyme-Linked Immunosorbent Assay; Epidemiology; Epithelium; Female; Gonorrhea; Herd Immunity; Human; Immune; Immune response; Immunity; Immunization; Immunologics; Immunology; In Vitro; Individual; Infection; Iron; Iron-Binding Proteins; Lactoferrin; Leukocyte L1 Antigen Complex; Libraries; Measures; Mediating; Membrane Proteins; Modeling; Mucous Membrane; Mus; Neisseria gonorrhoeae; Nutrient; Pathway interactions; Pelvic Inflammatory Disease; Pharyngeal structure; Population; Proteins; S100A7; Serum; Site; Source; Starvation; Structure; Testing; Tissues; Transferrin; Transgenic Mice; Trees; Urethra; Vaccine Design; Vaccines; Variant; Zinc; bactericide; complement 4b-binding protein; cross immunity; cross reactivity; design; epidemiological model; humanized mouse; immunogenicity; innovation; male; mathematical model; mouse model; pathogen; protective efficacy; rational design; reproductive tract; tool; transmission process; vaccine efficacy; vaccine evaluation; vaccine formulation

This Core component will take advantage of our established vaccine evaluation pipeline, which includes our innovative high throughput approaches facilitate our antigen engineering efforts by simultaneously allowing the reactivity of antiserum to be measured against all known antigenic variants of a given protein, and our humanized mouse-based infection models, which allow us to test the protective efficacy of vaccines during gonococcal asymptomatic colonization and disease. The results generated by this Core are central to vaccine design and formulation efforts being undertaken in Projects 1 and 2, and will be used to inform the vaccine impact modeling being performed in Project 3.

该核心组件将利用我们已建立的疫苗评估管道，其中包括我们的 创新的高通量方法通过同时允许 针对给定蛋白质的所有已知抗原变体测量抗血清的反应性，以及我们的 基于人源化的小鼠感染模型，使我们能够在感染期间测试疫苗的保护功效 淋球菌无症状定植和疾病。该核心产生的结果对于疫苗至关重要 项目 1 和 2 中正在进行的设计和配制工作，并将用于为疫苗提供信息 项目 3 中正在执行影响建模。