SUPPORT SERVICES FOR STUDIES OF PERINATAL TRANSMISSION

围产期传播研究的支持服务

• 批准号: 2315407
• 负责人: Stephen J Durako
• 金额: $ 258.15万
• 依托单位: WESTAT, INC.
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-01 至 1998-06-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2315407
• 关键词: SUPPORT; SERVICES; STUDIES; PERINATAL; TRANSMISSION

Since 1988, the National Institute of Child Health and Human Development (NICHD) has provided funding for a support services contract to conduct the Mothers and Infants Cohort Study (MIS) and the Women and Infants Transmission Study (WITS). These studies have focused on developing an understanding of the mechanisms by which women infected with HIV transmit their infection to their infants and the effects of HIV exposure on those infants, both among the infected and uninfected children. The studies have also examined the progression of disease in the women over time. The ascertainment of the immunologic, neurologic and neurodevelopmental problems and serious bacterial and opportunistic infections resulting from HIV infect ion in these studies is critical to developing appropriate measures of disease progression in clinical trials of new anti-retroviral drugs in HIV-infected children. The Mothers and Infants Cohort Study (MIS) has completed enrollment of its cohort of pregnant women and is currently focusing on major data analysis efforts under this new contract. While the initial clinical findings are expected to be completed in the next year, the follow-up of the children and the analysis of the wealth of data collected during the past five years of the project is expected to take approximately three to four more years to complete. The Women and Infants Transmission Study (WITS) continues to enroll HIV-infected pregnant women and has shifted its primary focus from determining the epidemiologic risk factors for transmission of infection from mother to infant to the determination of the timing of transmission (intrauterine versus intrapartum) and to methods of early diagnosis of infection in the infant. The ability to accurately determine the infection status of exposed infants at an earlier time will allow for pursuit of early intervention strategies to prevent progression of disease in infected infants, while avoiding potential exposure of uninfected infants to toxic therapies. The subject contract will continue to provide the support and analytical services required for the two studies.

自1988年以来，国家儿童健康与人类发展研究所 （NICHD）为支持服务合同提供了资金 母亲和婴儿队列研究（MIS）和妇女和婴儿 传输研究（WITS）。 这些研究的重点是开发 了解感染HIV传播的妇女的机制 他们感染对婴儿的感染以及艾滋病毒暴露对那些的影响 婴儿，包括受感染和未感染的儿童。研究有 随着时间的流逝，妇女的疾病进展。 这 免疫，神经和神经发育的确定 问题以及严重的细菌和机会性感染。 这些研究中的艾滋病毒感染离子对于开发适当的 新抗返回病毒的临床试验中疾病进展的度量 艾滋病毒感染儿童中的毒品。 母亲和婴儿队列研究（MIS）已完成其入学率 孕妇队列，目前正在关注主要数据分析 根据这项新合同的努力。 而最初的临床发现是 预计将在明年完成，对孩子的随访 以及对过去五个收集的数据的分析 预计该项目的几年将花费大约三到四个 多年完成。 妇女和婴儿传播研究（WITS） 继续注册HIV感染的孕妇，并改变了其 从确定流行病学风险因素的主要重点 从母亲到婴儿的感染传播到确定 传播的时机（宫内与肠内）和到 婴儿早期诊断感染的方法。 能力 准确确定早期暴露婴儿的感染状态 时间将允许追求早期干预策略以防止 感染婴儿疾病的进展，同时避免潜力 未感染的婴儿暴露于有毒疗法中。 主题合同 将继续提供所需的支持和分析服务 两项研究。