Center of Biomedical Research Excellence in CNS Metabolism

中枢神经系统代谢生物医学卓越研究中心

• 批准号: 10557542
• 负责人: Patrick G Sullivan
• 金额: $ 215.98万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-15 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10557542
• 关键词: Acceleration; Accounting; Alzheimer' s Disease; Area; Behavior; Biochemical; Bioenergetics; Bioinformatics; Biology; Biometry; Brain; Brain Injuries; Cardiovascular system; Centers of Research Excellence; Central Nervous System; Chronic; Clinical; Cognition; Collaborations; Complex; Core Facility; Data Science; Dedications; Defect; Development; Diabetes Mellitus; Disease; Ensure; Epilepsy; Equipment; Extramural Activities; Faculty; Fostering; Funding; Future; Glucose; Goals; Grant; Homeostasis; Infrastructure; Institution; Investments; Kentucky; Life; Link; Malignant Neoplasms; Mediator; Medicine; Memory; Mentors; Metabolic; Metabolic dysfunction; Metabolism; Methodology; Nervous System Physiology; Neurologic Dysfunctions; Neurons; Neurosciences; Neurosciences Research; Obesity; Outcome; Oxidation-Reduction; Parkinson Disease; Phase; Pilot Projects; Positioning Attribute; Process; Research; Research Personnel; Research Project Grants; Resources; Rest; Role; Scientist; Severity of illness; Structure; Synapses; System; Techniques; Therapeutic; Training; Translations; Traumatic Brain Injury; United States National Institutes of Health; Universities; biomarker discovery; brain metabolism; cohort; collaborative environment; college; data science resource; defined contribution; design; glucose metabolism; imaging capabilities; insight; instrumentation; interest; investigator training; metabolome; metabolomics; mitochondrial metabolism; multidisciplinary; nervous system disorder; neuroinflammation; neuronal excitability; neuropathology; neurophysiology; neurotransmission; neurotransmitter biosynthesis; novel; programs; protein TDP-43; recruit; skills; success; sustainability framework; synergism; systems research; translational impact

Central nervous system (CNS) metabolism and neuronal excitability are interdependent, and so CNS metabolism is the biochemical basis of cognition, memory, and behavior. Dysregulation of CNS is implicated in numerous disorders, including Alzheimer’s Disease, epilepsy, Parkinson’s disease, and brain injury, but the mechanistic connections between CNS metabolism and disease are poorly understood. The University of Kentucky (UK) College of Medicine has made significant investments over the last few years in investigators with metabolic and metabolomics expertise and instrumentation to support their research efforts, which has enhanced existing strengths in neuroscience, cancer, cardiovascular, and diabetes and obesity research. Thus, UK proposes to establish a unique multidisciplinary Center of Biomedical Research Excellence (COBRE) on CNS Metabolism (CNS-Met) as a strategically designed, sustainable framework that promotes leading-edge research focused on the role of metabolic mediators of brain function and disease. The proposed interdisciplinary center leverages highly specialized expertise in glucose biology, neuronal signaling, mitochondrial metabolism, systems neuroscience, and data sciences as well as the presence of advanced metabolomics and imaging capabilities to create an integrated research framework focused on CNS metabolism. The overarching goals are to strengthen UK’s neuroscience research enterprise by providing a thematically focused and sustainable multidisciplinary infrastructure dedicated to defining the contribution of metabolism to CNS function and neurological diseases and to use this novel platform to develop promising and highly-skilled, early-stage investigators in an exciting and impactful area of CNS research. To accomplish these goals, we will meet four specific aims: (1) Develop a critical mass of funded investigators with research programs directly related to the COBRE’s unifying theme; (2) provide strong team-based mentoring combining basic and clinical expertise; (3) recruit new investigators to the COBRE in multidisciplinary areas of neurologic dysfunction through pilot project grant and recruitment of junior Research Project Leaders; and (4) create synergy among research projects via critical links to strong research centers and core facilities at UK, including existing COBREs. Emerging synergies will be developed through three research projects, an Administrative Core, a critical research core in Metabolomics, all linked by strong biostatistics/bioinformatics support, all of which are critical to the proposed studies and will contribute to the development of institutional resources. The scientific focus of the three research projects are brain metabolism interactions with neurological disease, spanning basic and translational perspectives. This concentration of multidisciplinary expertise focused on widely recognized yet understudied metabolic mechanisms of neurological diseases promises significant new understandings of CNS metabolism overall. The CNS-Met will create a critical mass of skilled scientists who are well equipped to lead a sustainable research center focused on CNS metabolism into the future.

中枢神经系统 (CNS) 代谢和神经兴奋性是相互依赖的，因此 CNS 新陈代谢是认知、记忆和行为的生化基础，中枢神经系统的失调与中枢神经系统的失调有关。 许多疾病，包括阿尔茨海默病、癫痫、帕金森病和脑损伤，但 中枢神经系统代谢与疾病之间的机制联系知之甚少。 肯塔基（英国）医学院在过去几年中对研究人员进行了大量投资 拥有代谢和代谢组学专业知识和仪器来支持他们的研究工作， 增强了神经科学、癌症、心血管、糖尿病和肥胖研究方面的现有优势。 因此，英国提议建立一个独特的多学科生物医学卓越研究中心（COBRE） 中枢神经系统代谢 (CNS-Met) 作为一个战略设计的可持续框架，可促进前沿技术的发展 研究重点是代谢介质对大脑功能和疾病的作用。 跨学科中心利用葡萄糖生物学、神经信号传导、 线粒体代谢、系统神经科学和数据科学以及先进技术的存在 代谢组学和成像能力创建专注于中枢神经系统的综合研究框架 总体目标是通过提供一个新的途径来加强英国的神经科学研究事业。 以主题为重点且可持续的多学科基础设施，致力于确定以下领域的贡献： 代谢对中枢神经系统功能和神经系统疾病的影响，并利用这个新平台进行有前途的开发和 中枢神经系统研究令人兴奋且有影响力的领域的高技能、早期研究人员。 这些目标，我们将实现四个具体目标：（1）培养一批受资助的研究人员 (2) 提供强有力的团队指导 基础和临床专业知识；(3) 为 COBRE 招募神经学多学科领域的新研究人员 通过试点项目拨款和招募初级研究项目负责人来解决功能障碍；以及（4）创建 通过与英国强大的研究中心和核心设施的关键联系，研究项目之间的协同作用，包括 现有的 COBRE 将通过三个研究项目来发展，一个是行政项目。 核心，代谢组学的关键研究核心，所有这些都通过强大的生物统计学/生物信息学支持联系起来，所有 这对拟议的研究至关重要，并将有助于机构资源的开发。 这三个研究项目的科学重点是大脑代谢与神经系统疾病的相互作用， 跨越基础和转化视角的多学科专业知识的集中。 广泛认可但尚未充分研究的神经系统疾病代谢机制有望带来重大新进展 CNS-Met 将培养一批熟练的科学家。 完全有能力领导一个专注于中枢神经系统代谢的可持续研究中心的未来。