PEDIATRIC LUNG AND COMPLICATIONS OF HIV INFECTION

小儿肺部和艾滋病毒感染的并发症

• 批准号: 3657670
• 负责人: DAVID F TEITEL
• 金额: --
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-05-22 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3657670
• 关键词: HIV infections; cooperative study; disease /disorder proneness /risk; heart disorder; human pregnant subject; human subject; infant human (0-1 year); longitudinal human study; newborn human (0-6 weeks); opportunistic infections; perinatal; respiratory disorder

We propose to work within the context of 2 NIH-funded grants at our institutions to define abnormalities in cardiac and pulmonary function that occur in infants as young children with Human Immunodeficiency Virus infection. The importance of HIV itself will be determined by comparing the study group of infants with HIV infection with control groups of seronegative infants from either seropositive mothers or high risk, seronegative mothers. We will determine the extent of cardiopulmonary dysfunction in symptomatic infants by more invasive studies, institute appropriate therapy. The 2 ongoing grants are the Bay Area Perinatal AIDS Center and the Northern California Pediatric AIDS Treatment Center. The first project documents the natural history of maternal-infant pairs in which the mother is either seropositive for HIV or is seronegative but in a high risk group, and will be the source of our control patients. Infants who subsequently develop HIV infection will be enrolled in the second project, the Pediatric AIDS Treatment Center. These infants, along with other infants in the Treatment Center diagnosed with HIV infection but who were not enrolled in the Perinatal Center, will be the source of our study group. They undergo intensive immunologic, infectious, psychometric and neurologic evaluations on a quarterly basis, and we will coordinate its studies with the existing follow-up schedules whenever possible, so that the patients are not required to make additional visits.

我们建议在我们的2个NIH资助的赠款的背景下工作 定义心脏和肺功能异常的机构 在婴儿的婴儿免疫缺陷病毒的婴儿中发生 感染。 艾滋病毒本身的重要性将通过比较 患有HIV感染的婴儿的研究组，对照组 来自血清阳性母亲或高风险的血清神经婴儿， 血清神经母亲。 我们将确定心肺的程度 研究所通过更多侵入性研究的有症状婴儿功能障碍 适当的疗法。 这两个正在进行的赠款是湾区围产期艾滋病中心和 北加州小儿艾滋病治疗中心。 第一个项目 记录母亲对母亲的自然历史 对艾滋病毒的血清阳性或血清阴性，但在高风险组中， 并将成为我们对照患者的来源。 随后的婴儿 开发艾滋病毒感染将被招募到第二个项目，即 小儿艾滋病治疗中心。 这些婴儿，以及其他婴儿 在被诊断为艾滋病毒感染的治疗中心，但没有 进入围产期中心将成为我们研究组的来源。 他们接受密集的免疫学，传染性，心理测量和神经系统 每季度进行评估，我们将与 如有可能，现有的后续时间表，以便患者 不需要进行额外的访问。