The Neurobiology of Drug Abuse

药物滥用的神经生物学

• 批准号: 10555567
• 负责人: SARA RAULERSON JONES
• 金额: $ 21.52万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10555567
• 关键词: Drug abuse; Neurobiology

NEUROBIOLOGY OF DRUG ABUSE TRAINING PROGRAM SUMMARY One of the keys to developing effective prevention and treatment strategies for substance use disorder is understanding the neurobiological consequences of chronic exposure to drugs of abuse. Such studies must involve multi-disciplinary approaches to examine several different levels of brain function. This is the goal of our current training program, the Neurobiology of Drug Abuse Training Program, which proposes to continue a successful tradition of NIDA training at Wake Forest School of Medicine (WFSM). This program requests funding to train five predoctoral students in a multi-disciplinary program in the neurobiology of drug abuse. The program includes 24 faculty members at WFSM, with research interests spanning molecular biology, receptor pharmacology, brain imaging techniques in humans and non-human primates, electrophysiology, neuronal activity monitoring and behavioral analysis of drug self- administration. The research of the faculty is supported by a significant number of federally-funded grants related to the field of substance abuse. The training program is organized around three principal areas of research: Molecular/Cellular Neurobiology, Neurobiological Systems, and Behavioral Neurobiology. The training program offers a specific course in drug abuse covering topics related to each of these three areas. Predoctoral students have a choice of two different Ph.D. degree tracks: Integrated Physiology/Pharmacology and Neuroscience. Although these programs have their own individual requirements, specific drug abuse-related topics are integrated into the standard programs. The training program offers specific seminars and journal clubs for trainees and opportunities for additional substance abuse training. The program also contains specialized components dealing with statistics/data analytics, grant writing, rigor and transparency in research, and ethics in scientific research. Recruitment of students will be aided by the fact that the field of neuroscience is one of the fastest growing disciplines in the biological sciences, and WFSM is undergoing a strong research growth phase. In addition, recruitment of applicants from under- represented minorities will be a high priority, including undergraduate training programs with Winston Salem State University, North Carolina A&T University and North Carolina Central University. In summary, the Neurobiology of Drug Abuse Training Program not only offers students outstanding opportunities for education and research in the neurobiology of drug abuse but is also a valuable resource for the field of drug abuse by providing trained young investigators capable of independent scientific careers.

药物滥用神经生物学培训计划摘要 制定有效的药物使用障碍预防和治疗策略的关键之一是 了解长期接触滥用药物的神经生物学后果。此类研究必须 涉及多学科方法来检查几个不同水平的大脑功能。这就是目标 我们目前的培训计划，药物滥用神经生物学培训计划，建议继续 维克森林医学院 (WFSM) 的 NIDA 培训的成功传统。该程序要求 资助培训五名博士前学生参加药物滥用神经生物学的多学科项目。这 项目包括 WFSM 的 24 名教员，研究兴趣涵盖分子生物学、受体 药理学、人类和非人类灵长类动物的脑成像技术、电生理学、神经元 药物自我给药的活动监测和行为分析。该学院的研究是 得到了大量与药物滥用领域相关的联邦资助的赠款的支持。这 培训计划围绕三个主要研究领域组织：分子/细胞神经生物学， 神经生物学系统和行为神经生物学。该培训计划提供了药物方面的具体课程 滥用涵盖与这三个领域相关的主题。博士前学生有两种不同的选择 博士学位课程：综合生理学/药理学和神经科学。虽然这些计划有 他们自己的个人要求，特定的药物滥用相关主题已纳入标准 程序。该培训计划为学员提供特定的研讨会和期刊俱乐部以及 额外的药物滥用培训。该程序还包含专门的组件来处理 统计/数据分析、资助写作、研究的严谨性和透明度以及科学研究的道德规范。 神经科学领域是发展最快的领域之一，这一事实将有助于招收学生 WFSM 正在经历一个强劲的研究增长阶段。此外， 招聘来自代表性不足的少数族裔的申请者将是一个高度优先事项，包括本科生 与温斯顿塞勒姆州立大学、北卡罗来纳州 A&T 大学和北卡罗来纳州合作的培训项目 中央大学.总之，药物滥用神经生物学培训项目不仅为学生提供 药物滥用神经生物学方面的教育和研究的绝佳机会，也是一个宝贵的机会 为药物滥用领域提供资源，提供训练有素、能够进行独立科学研究的年轻调查员 职业生涯。

项目成果

Use of Quantitative Electroencephalography to Inform Age- and Sex-Related Differences in NMDA Receptor Function Following MK-801 Administration.

使用定量脑电图来了解 MK-801 给药后 NMDA 受体功能的年龄和性别相关差异。

• 发表时间: 2024-02-11
• 作者: Holter, Kimberly M;Lekander, Alex D;Pierce, Bethany E;Sands, L Paul;Gould, Robert W
• 通讯作者: Gould, Robert W

β2 nAChR Activation on VTA DA Neurons Is Sufficient for Nicotine Reinforcement in Rats.

VTA DA 神经元上的 β2 nAChR 激活足以增强大鼠的尼古丁。

• 发表时间: 2023-05
• 影响因子: 3.4
• 作者: Walker, Noah B;Yan, Yijin;Tapia, Melissa A;Tucker, Brenton R;Thomas, Leanne N;George, Brianna E;West, Alyssa M;Marotta, Christopher B;Lester, Henry A;Dougherty, Dennis A;Holleran, Katherine M;Jones, Sara R;Drenan, Ryan M
• 通讯作者: Drenan, Ryan M

Changes in environmental stress over COVID-19 pandemic likely contributed to failure to replicate adiposity phenotype associated with Krtcap3.

COVID-19 大流行造成的环境压力变化可能导致无法复制与 Krtcap3 相关的肥胖表型。

• 发表时间: 2023-10-01
• 影响因子: 4.6
• 作者: Szalanczy, Alexandria M;Giorgio, Gina;Goff, Emily;Seshie, Osborne;Grzybowski, Michael;Klotz, Jason;Geurts, Aron M;Redei, Eva E;Solberg Woods, Leah C
• 通讯作者: Solberg Woods, Leah C

Chronic stress from adolescence to adulthood increases adiposity and anxiety in rats with decreased expression of Krtcap3.

Krtcap3 表达降低的大鼠从青春期到成年期的慢性应激会增加肥胖和焦虑。

• 发表时间: 2023
• 作者: Szalanczy, Alexandria M;Fitzpatrick, Mackenzie;Beeson, Angela;Bui, Trangdai;Dyson, Christina;Eller, Seth;Landry, Julia;Scott, Christina;Grzybowski, Michael;Klotz, Jason;Geurts, Aron M;Weiner, Jeff L;Redei, Eva E;Solberg Woods, Leah C
• 通讯作者: Solberg Woods, Leah C

PET imaging of kappa opioid receptors and receptor expression quantified in neuron-derived extracellular vesicles in socially housed female and male cynomolgus macaques.

对社会饲养的雌性和雄性食蟹猴的神经元源性细胞外囊泡中的卡帕阿片受体和受体表达进行定量的 PET 成像。

• 发表时间: 2023-01
• 作者: Johnson, Bernard N;Kumar, Ashish;Su, Yixin;Singh, Sangeeta;Sai, Kiran Kumar Solingapuram;Nader, Susan H;Li, Songye;Reboussin, Beth A;Huang, Yiyun;Deep, Gagan;Nader, Michael A
• 通讯作者: Nader, Michael A