Surgical Oncologists as Scientists (SOAS) Training Program

肿瘤外科医师科学家 (SOAS) 培训计划

基本信息

批准号：
10555596
负责人：
Yuan Chen
金额：
$ 17.03万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10555596
关键词：
Scientist Surgical Oncologist Training Programs

项目摘要

PROJECT SUMMARY / ABSTRACT Translational cancer research that improves patient health requires a multi-disciplinary approach that advances innovative discoveries from (A) basic research to (B) preclinical validation (often utilizing biobanked tissue) to (C) clinical implementation via entrepreneurship and commercialization. But surgeons rarely receive formal training in biobanking and entrepreneurship, and few programs are designed to formally train surgeons in the cancer biology and the tumor microenvironment (TME). Recognizing these critical gaps in training surgeon- scientists, the Department of Surgery and the Moores Cancer Center (NCI-Designated Comprehensive Cancer Center) and the Department of Surgery at the University of California San Diego (UC San Diego) propose a new program to support training for MD/DO surgeon-scientists who show objective evidence of a commitment to a career in academic surgical oncology for a two-year training program. We will create the Surgical Oncologists as Scientists (SOAS) Training Program centered on formal training in three topics: 1) the TME; 2) biobanking; and 3) innovation/entrepreneurship. The rationale for TME training is that increasingly, the oncologic surgeon- scientist needs to thoroughly understand details of how the TME plays significant roles in cancer initiation, progression, metastasis, response to therapies, and serves as novel targets for anti-cancer drugs. The rationale for training in biobanking is that academic surgeons are frequently asked to collaborate in research because their unparalleled access to human specimens, which must be properly banked in a dedicated biorepository. Finally, the rationale for innovation/entrepreneurship training involves the critical need to ensure that research training of surgeon-scientists has real-world translational relevance—that is, we need to demonstrably improve cancer care, not merely improve understanding. This rationale leverages the metropolitan San Diego area as the third largest assembly of components necessary to successfully translate (i.e., commercialize) innovations into Food and Drug Administration (FDA)-approved clinical realities. San Diego includes a plethora of biotech startups (hundreds spun out of UC San Diego), Angel investors, private equity and venture capital firms, contract research organizations, and local networking activities. The SOAS program will be co-led by a surgical oncologist/translational scientist and a PhD scientist that bring complementary, but unique skills in science and experience in innovation. Research training will occur within one of 14 Faculty Mentor’s laboratories, each of which has solid, continuous R01 NIH funding, and each has a strong record of successful mentorship. Also, Trainees will develop co-mentoring relationships with at least one of our 9 Entrepreneurial Liaison Advisors, each of whom has practical experience with translation (e.g., patents, start-ups). The SOAS Training Program will train collaborative surgeon-scientists to become future leaders in academic surgery and oncology to actively participate in translating innovative new discoveries into clinical cancer care.

项目概要/摘要改善患者健康的转化癌症研究需要采用多学科方法来推进从 (A) 基础研究到 (B) 临床前验证（通常利用生物库组织）的创新发现（三）通过创业和商业化进行临床实施但外科医生很少接受正式的培训。生物样本库和创业方面的培训，很少有项目旨在正式培训外科医生认识到癌症生物学和肿瘤微环境（TME）在培训外科医生方面的关键差距。科学家、外科部和摩尔斯癌症中心（NCI 指定综合癌症中心）中心）和加州大学圣地亚哥分校（UC San Diego）外科系提出了一项新的计划支持对 MD/DO 外科医生科学家进行培训，这些科学家表现出客观证据表明致力于我们将创建外科肿瘤学家，进行为期两年的学术外科肿瘤学职业生涯。科学家 (SOAS) 培训计划集中于三个主题的正式培训：1) TME；2) 生物样本库； 3）创新/创业精神 TME 培训的基本原理是肿瘤外科医生越来越多地科学家需要彻底了解 TME 如何在癌症发生中发挥重要作用的细节，进展、转移、对治疗的反应，并作为抗癌药物的新靶标。对于生物样本库培训来说，学术外科医生经常被要求进行研究合作，因为他们拥有无与伦比的获取人体标本的能力，而这些标本必须妥善存放在专用的生物储存库中。最后，创新/创业培训的基本原理涉及确保以下关键需求：外科医生科学家的研究培训具有现实世界的转化相关性——也就是说，我们需要明显地改善癌症护理，而不仅仅是提高理解这一基本原理利用了圣地亚哥大都市。作为成功翻译（即商业化）所需的第三大组件组件的区域圣地亚哥经食品药品监督管理局 (FDA) 批准的临床实践的创新包括大量的创新。生物技术初创公司（数百家从加州大学圣地亚哥分校分拆出来）、天使投资人、私募股权和风险投资 SOAS 计划将由公司、合同研究组织和本地网络活动共同领导。外科肿瘤学家/转化科学家和博士科学家带来了互补但独特的技能科学和创新经验方面的研究培训将在 14 名教师导师的其中一位进行。每个实验室都拥有坚实、持续的 R01 NIH 资助，并且每个实验室都有良好的成功记录此外，学员将与我们的 9 名企业家中的至少一位建立共同指导关系。联络顾问，每个人都有翻译方面的实践经验（例如专利、初创企业）。培训计划将培训合作外科医生科学家，使其成为学术外科和医学领域的未来领导者。肿瘤学积极参与将创新新发现转化为临床癌症护理。