Core 1: Integrated Pathology and Radiology Core (iPRC)

核心 1：综合病理学和放射学核心 (iPRC)

基本信息

批准号：
10555403
负责人：
Wei Huang
金额：
$ 31.94万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10555403
关键词：
3-Dimensional Address Bioinformatics Biological Markers Body Fluids Cancer Center Cancer Patient Cancer Research Project Clinical Clinical Trials Collaborations Communities Consultations Correlation Studies Data Databases Dedications FOLH1 gene Formalin Freezing Future Goals Hematoxylin and Eosin Staining Method Histologic Histology Histopathology Image Immunofluorescence Immunologic Immunohistochemistry Infrastructure Lesion Link Localized Lesion Magnetic Resonance Imaging Malignant neoplasm of prostate Mission Molds Neoplasm Circulating Cells Neoplasm Metastasis Organoids Paraffin Embedding Pathology Peripheral Blood Mononuclear Cell Plasma Positron-Emission Tomography Process Prostate Prostatectomy Radiation therapy Radiology Specialty Reproducibility Research Personnel Resistance Resources Services Stains Technology Tissue Embedding Tissue Microarray Tissues Treatment outcome Tumor Pathology Universities Wisconsin anticancer research cancer imaging castration resistant prostate cancer clinically significant design digital image archival system image translation pathology imaging patient derived xenograft model preservation prostate cancer cell quantitative imaging radiological imaging repository treatment response tumor whole slide imaging

项目摘要

PROJECT SUMMARY The Integrated Pathology Radiology Core (iPRC) of the UW Prostate Cancer SPORE is dedicated to providing expert and reliable pathology and imaging services to enhance translational prostate cancer (PC) research. The theme of this core is to provide our UW Prostate Cancer SPORE investigators with a wide range of integrated and coordinated pathology and radiology services including high quality and extensively annotated biospecimens, state-of-the-art pathology, and advanced radiology imaging. The iPRC will provide services and infrastructure to allow for reliable, reproducible, and high-quality pathology data to be linked with radiologic imaging tumor identification and lesion-to-lesion correlation. This will integrate pathology-radiology data and be linked to comprehensive clinical information as well as tumor-specific bioinformatics. The mission of the iPRC is to provide the type and quality of services that will enable Prostate Cancer SPORE investigators to address pathology, radiology, and quantitative imaging translational aims as well as generate reliable and clinically significant findings that will impact treatment outcomes. Successful accomplishment of many of the translational aims of the Prostate Cancer SPORE projects is dependent on the iPRC services. The specific aims of the iPRC are strategically designed to produce a core service unique from existing cancer center cores that will directly meet the needs of the Prostate Cancer SPORE projects and build a sustainable central organizing force for future translational PC research. The unique infrastructure and resources created to support the UW Prostate Cancer SPORE projects will provide an integrated pathology and radiology database repository to benefit collaborative translational PC research projects at UW and the wider PC research community.

项目概要华盛顿大学前列腺癌 SPORE 的综合病理学放射学核心 (iPRC) 致力于提供专家可靠的病理学和影像学服务，以加强转化性前列腺癌 (PC) 研究。这该核心的主题是为我们的威斯康星大学前列腺癌 SPORE 研究人员提供广泛的综合协调病理学和放射学服务，包括高质量和广泛注释生物样本、最先进的病理学和先进的放射成像。 iPRC 将提供服务和基础设施允许可靠、可重复和高质量的病理数据与放射学相关联影像学肿瘤识别和病变与病变的相关性。这将整合病理学-放射学数据并与全面的临床信息以及肿瘤特异性生物信息学相关。 iPRC 的使命是提供服务类型和质量，使前列腺癌 SPORE 研究人员能够解决病理学、放射学和定量成像转化目标以及产生可靠的临床结果将会影响治疗结果的重大发现。成功完成多项翻译工作前列腺癌 SPORE 项目的目标取决于 iPRC 服务。 iPRC 的具体目标经过战略设计，旨在提供不同于现有癌症中心核心的独特核心服务，该服务将直接满足前列腺癌SPORE项目的需求并建立可持续的中央组织力量未来的转化计算机研究。为支持威斯康星大学前列腺学院而创建的独特基础设施和资源 Cancer SPORE 项目将提供一个综合的病理学和放射学数据库存储库，以受益华盛顿大学和更广泛的 PC 研究界的合作转化 PC 研究项目。