CHRONIC TOXICITY OF METHYLPHENIDATE HYDROCHLORIDE

盐酸哌甲酯的慢性毒性

• 批准号: 3641568
• 负责人: CATHERINE ARANYI
• 金额: $ 4.72万
• 依托单位: TSI MASON LABORATORIES
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-02-28 至 1990-12-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3641568
• 关键词: blood chemistry; body weight; bone density; central nervous system; cytotoxicity; enzyme mechanism; gender difference; hematopoiesis; histopathology; kidney function; laboratory mouse; laboratory rat; liver function; methylphenidate; nutrient intake activity; species difference

Methylphenidate, hydrochloride (CAS No. 298-59-9) will be administered in feed to male and female F344/N rats and B6C3F1 mice for 104 weeks, in order to determine the effects of chronic exposure. Interim tests (clinical chemistry and hematology, clinical observations, and histopathology) will be performed at 39 and 65 weeks of treatment. Clinical observations, body weights, feed consumption, and histopathology on animals dying early, will be performed routinely. This data will be used to determine: (1) target organs related to treatment, (2) effects of treatment on central nervous system, bone, weight gain, liver and kidney function, serum enzymes, hematopoiesis, (3) difference in sensitivity between species and sexes, and (4) carcinogenic potential.

将在 喂给雄性和雌性F344/N大鼠和B6C3F1小鼠104周， 确定慢性暴露的影响。 临时测试（临床 化学和血液学，临床观察和组织病理学）将 在治疗39和65周时进行。 临床观察，身体 对早日垂死的动物的体重，饲料消耗和组织病理学将 定期执行。 该数据将用于确定：（1）目标 与治疗有关的器官，（2）治疗对中枢神经的影响 系统，骨骼，体重增加，肝脏和肾功能，血清酶， 造血，（3）物种和性别之间的敏感性差异，以及 （4）致癌潜力。