CHEMISTRY SUPPORT SERVICES FOR THE NTP

NTP 化学支持服务

• 批准号: 2308261
• 负责人: RW HANDY
• 金额: $ 42万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-01-04 至 1996-02-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2308261
• 关键词: CHEMISTRY; SUPPORT; SERVICES; NTP

The objective of the contract is to provide chemistry support services for the System Toxicity Branch contract toxicology effort and for in-house research projects. Prior to the start of a study or research project, this support consists of the procurement and chemical characterization of test chemicals, analyses to confirm stability of the test chemical during storage, and purity and identity analyses of the test chemical. During the course of a study, support will include analyses performed to confirm that no degradation of the test material has occurred and dose formulation analyses for chemical content. For in-house research projects dose formulations may be prepared and analyzed during the course of the project. Formulations which meet study specifications for chemical concentration will be delivered to the researcher at NIEHS. Many of these analyses will require development of new chemical analysis methodologies for the determination of the test chemical in various matrices, i.e., feed, corn oil, water, or methylcellulose, etc. Post study chemistry support include confirmation of the purity of the test chemical and quantification of the chemical and metabolites present in various biological tissues and fluids. Special analyses, i.e., the determination of vapor or aerosol concentrations in an inhalation exposure system, or identification of impurities in a test chemical, may be required. For options 1 and 2, similar services will be provided for test chemicals which are mixtures. Option 3 provides similar services for AIDS Therapeutics, with the addition of tasks to perform pilot scale toxicokinetic studies in laboratory mice and rats.

合同的目的是为 系统毒性分支分支合同毒理学和内部 研究项目。 在开始研究或研究项目之前， 支持由测试的采购和化学表征组成 化学药品，分析以确认测试化学物质的稳定性 测试化学物质的储存以及纯度和身份分析。 在 研究过程，支持将包括进行分析以确认 未发生测试材料的降解和剂量配方 分析化学含量。 内部研究项目剂量 在项目过程中可以准备和分析配方。 符合化学浓度的研究规格的配方 将交付给NIEHS的研究人员。 其中许多分析将 需要开发新的化学分析方法 测定各种矩阵中的测试化学物质，即饲料，玉米 油，水或甲基纤维素等。研究化学支持包括 确认测试化学的纯度和定量 化学和代谢物存在于各种生物组织和液体中。 特殊分析，即确定蒸气或气溶胶 吸入系统中的浓度或识别 可能需要测试化学物质中的杂质。 对于选项1和2， 将为混合物提供类似的服务。 选项3为AIDS Therapeutics提供了类似的服务，并增加了 在实验室小鼠中执行试验量表有毒动力学研究的任务 和老鼠。