Testing a Biosocial Model of Borderline Personality Features in Youth

测试青少年边缘人格特征的生物社会模型

基本信息

批准号：
10556483
负责人：
Dara E Babinski
金额：
$ 16.6万
依托单位：
PENNSYLVANIA STATE UNIV HERSHEY MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10556483
关键词：
14 year old Address Adolescent Attention Behavior Biological Process Biosocial Birth Categories Clinical Cues Data Development Dimensions Emergency department visit Failure Feeling suicidal Female Gender Gender Identity Growth Health Hospitalization Individual Differences Inpatients Intervention Laboratories Literature Loneliness Measures Mental Health Modeling National Institute of Mental Health Outcome Parents Pathway interactions Patient Self-Report Personality Population Prevention Reporting Research Research Domain Criteria Risk Sampling Sexual and Gender Minority Youth Social Processes Suicide Suicide attempt Testing Time Treatment Cost United States National Institutes of Health Vulnerable Populations Work Youth expectation experience gender diversity gender nonconforming individualized prevention neurophysiology non-suicidal self injury peer peer support prospective recruit relating to nervous system resilience response sex social social deficits suicidal risk suicide model suicide rate

项目摘要

Project Summary Gender diverse youth assigned female at birth (AFAB) experience high rates of suicide-related behavior, including suicidal ideation, suicide attempts, and non-suicidal self-injury that are associated with long-term and costly treatment, inpatient hospitalizations, and emergency room visits. Yet very little is known about mechanisms underlying the profound risk for suicide among gender diverse youth AFAB, hindering efforts to address the personal and societal burden associated with suicide in this vulnerable population. The need to belong is central to prominent models of suicide, and failure to acquire close, reciprocal relationships is posited to beget suicide-related behaviors. As many gender diverse youth AFAB report profound loneliness, the NIMH RDoC Social Processes construct of Attachment and Affiliation may be of primary relevance to understanding the emergence of suicide-related behavior. Attachment and Affiliation deficits, namely heightened sensitivity to peer rejection cues and blunted responses to peer acceptance cues, have been associated with difficulties forming and maintaining relationships with others and have also been associated with risk for suicide-related behaviors. However, most work has relied on self-report measures of social processing, which may be limited in detecting the precise deficits involved in social processing. A priori prospective research examining neural alterations in social processing is needed to clarify the pathway through which Attachment and Affiliation deficits beget suicide-related behavior. Indeed, emerging research suggests gender diverse youth AFAB have particularly high rates of social dysfunction and suicide-related behavior compared to other sexual and gender minority youth groups. In response to NOT-OD-22-030, we seek to critically examine gender diversity using developmentally sensitive measures, including felt-gender, gender noncontentedness, and gender nonconformity, in a clinically diverse sample of 180 early adolescent youth AFAB (10-14 years old) recruited from R21 MH125052 and R21 MH124027. Neural alterations in processing of peer rejection and acceptance cues will be tested as mechanisms underlying the emergence of suicide-related behavior measured one year later in gender diverse youth AFAB. Parent and peer risk and resilience factors will also be explored. It is anticipated that findings from this work will clarify targets for intervention and direct efforts to mitigate risk for suicide-related behaviors in gender diverse youth AFAB.

项目概要出生时指定为女性的性别多样化青年 (AFAB) 的自杀相关行为发生率很高，包括自杀意念、自杀未遂和与长期和长期相关的非自杀性自残昂贵的治疗、住院治疗和急诊室就诊。然而人们却知之甚少性别多样化青年 AFAB 存在巨大自杀风险的机制，阻碍了解决这一弱势群体中与自杀相关的个人和社会负担。需要归属感是著名自杀模式的核心，并且假定未能获得密切、互惠的关系产生与自杀相关的行为。由于许多性别不同的青年 AFAB 报告了深深的孤独感，NIMH RDoC 社会过程的依恋和归属可能与理解具有主要相关性自杀相关行为的出现。依恋和归属感缺陷，即对同伴拒绝暗示和对同伴接受暗示的迟钝反应与困难有关与他人建立和维持关系，也与自杀相关的风险有关行为。然而，大多数工作依赖于社会处理的自我报告措施，这可能仅限于检测社会处理中涉及的精确缺陷。检查神经的先验前瞻性研究需要改变社会处理过程来澄清依恋和归属缺陷的途径产生与自杀相关的行为。事实上，新兴研究表明，性别多样化的青年 AFAB 与其他性别相比，社会功能障碍和自杀相关行为的发生率特别高少数民族青年团体。为了回应 NOT-OD-22-030，我们寻求使用批判性的方法来审视性别多样性发展敏感指标，包括性别感受、性别不满足感和性别不合格，在招募 180 名青春期早期青年 AFAB（10-14 岁）的临床多样化样本中来自 R21 MH125052 和 R21 MH124027。处理同伴拒绝和接受的神经改变线索将作为自杀相关行为出现的机制进行测试，每年测量一次后来加入性别多元化青年 AFAB。还将探讨家长和同伴的风险和复原力因素。这是预计这项工作的结果将澄清干预目标并直接努力减轻风险性别多样化青年 AFAB 中的自杀相关行为。