CARCINOGENICITY STUDIES OF HEACHLOROCYCLOPENTADIENE

全氯环戊二烯的致癌性研究

• 批准号: 2308958
• 负责人: ALFRED P WEHNER
• 金额: --
• 依托单位: BATTELLE PACIFIC NORTHWEST LABORATORIES
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-06-30 至 1989-02-10
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2308958
• 关键词: blood chemistry; chemical carcinogen; chemical carcinogenesis; cytotoxicity; environment related neoplasm /cancer; environmental toxicology; inhalation drug administration; laboratory mouse; laboratory rat; neurotoxins; urinalysis

The objective of this project is to characterize dose-response relationships and toxicity of hexachlorocyclopentadiene administered by inhalation to male and female rats and mice in 90-day subchronic and 2-year chronic studies. Animals will be exposed for 6 hours per day, 5 days per week for 13 and 104 weeks. At the end of each study, all animals will be given gross and microscopic histopathologic evaluations. Hematology, urinalysis, and clinical chemistries analyses will be performed on all animals in the 13-week studies. Hematology and clinical pathology will be evaluated on all animals sacrificed at the 65th week of the chronic study. The results of the 13-week study will be used by NTP to establish doses to be used in the chronic study. The results of the 2-year chronic study will be used by NTP to determine toxicologic and carcinogenic effects of inhalation administration of hexachlorocyclopentadiene.

该项目的目标是表征剂量反应 六氯环戊二烯的关系和毒性 雄性和雌性大鼠和小鼠在 90 天亚慢性和 2 年吸入 长期研究。 动物每天暴露 6 小时，每次暴露 5 天 周为 13 周和 104 周。 在每次研究结束时，所有动物都将被 进行肉眼和显微镜组织病理学评估。 血液学， 将对所有患者进行尿液分析和临床化学分析 为期 13 周的研究中的动物。 血液学和临床病理学将 对慢性研究第 65 周处死的所有动物进行评估。 NTP 将使用为期 13 周的研究结果来确定治疗剂量 用于慢性研究。 为期两年的长期研究的结果将 被 NTP 用于确定毒理学和致癌作用 六氯环戊二烯的吸入给药。