Research Training Program in Adolescent HIV in Haiti

海地青少年艾滋病毒研究培训项目

• 批准号: 10543997
• 负责人: JEAN WILLIAM PAPE
• 金额: $ 30.14万
• 依托单位: GHESKIO CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-22 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10543997
• 关键词: AIDS prevention; Address; Adolescent; Adult; Area; Black American; Caring; Clinic; Communities; Community Health Aides; Data; Development; Disease; Doctor of Philosophy; Educational Status; Epidemic; Female; Foundations; Future; Grooming; HIV; HIV-infected adolescents; HIV/TB; Haiti; Haitian; Health; Hypertension; Improve Access; Incidence; Infection; Medicine; Outcome; Poverty; Psychologist; Public Health; Public Health Education; Research; Research Support; Research Training; Services; Stigmatization; Training; Training Programs; Training Support; Treatment outcome; Tuberculosis; UNICEF; United States National Institutes of Health; Validation; Youth; adolescent health; adolescent health outcomes; aged; antiretroviral therapy; co-infection; cohort; community based research; cost effectiveness; early onset; improved; next generation; programs; social

This proposal builds on the foundation established in Haiti during three decades of NIH research and training support to Groupe Haitien d’Etude du Sarcome et des Infections Opportunistes (GHESKIO) and Weill Cornell Medicine (WCM) to address the burgeoning adolescent HIV epidemic in Haiti. The focus of this training program is to improve HIV-related health outcomes of adolescents (10 to 19 years) and youth (20 to 24 years) in Haiti. A major emphasis is research-training to extend adolescent HIV services from the clinic to the community. Evidence demonstrates that providing services in the community improves access, social acceptability, cost-effectiveness, and ultimately large-scale impact. This program extends graduate level training in Haiti by establishing Haiti’s first PhD program in Public Health. We build upon an MPH program established in Haiti with prior Fogarty support. A cadre of 8 Haitian long-term trainees will receive research training – 4 will receive an MPH and 4 will receive a PhD – the first cohort with doctoral level public health training in Haiti. The research training will focus on adolescent health in the areas of 1) HIV prevention, 2) HIV treatment, 3) HIV and TB co-infection, and 4) HIV and NCDs. Trainees will be groomed to be the future leaders of adolescent health research at GHESKIO and the Haitian Ministry of Health. The program will also include medium-term training (6-12 months) of research staff including psychologists (4), data managers (4), and community health workers (4) to establish community-based research teams. In Haiti, 50% of all new HIV infections are in adolescents and youth, and 80% of these are impoverished and stigmatized females. UNICEF has declared adolescents the ‘center of the HIV epidemic’. HIV-infected adolescents and youth have poor antiretroviral treatment outcomes with only 50% remaining in care after 1 year, compared to 90% retention among adults. The period between 10 and 24 years is the peak incidence of TB infection and disease. Furthermore, only 40% of HIV-infected adolescents with culture-positive TB successfully complete therapy. Finally the rate of early onset hypertension in adolescents and youth in Haiti is 12% - 3-fold greater than in similarly aged Black Americans. The development and validation of community-based approaches to identify, engage, and retain adolescents and youth in care will lead to sustainable improvements in health outcomes in Haiti. This program responds to the priorities of the Haitian Ministry of Health and will train the next generation of Haitian leaders in the conduct of community-based adolescent HIV research.

该提案建立在 NIH 三十年来在海地建立的基础之上 为海地肉瘤和感染研究小组提供研究和培训支持 Opportunistes (GHESKIO) 和威尔康奈尔医学 (WCM) 致力于解决这一新兴问题 海地青少年艾滋病毒流行情况 该培训计划的重点是改善与艾滋病毒相关的情况。 海地青少年（10 至 19 岁）和青年（20 至 24 岁）的健康状况 A 主要。 重点是研究培训，将青少年艾滋病毒服务从诊所扩展到社区 证据表明，在社区中提供服务可以改善获取服务的机会， 社会可接受性、成本效益以及最终的大规模影响。 该计划通过建立海地第一个博士学位来扩展海地的研究生水平培训 我们以福格蒂在海地建立的公共卫生硕士项目为基础。 8 名海地长期培训人员将接受研究培训，其中 4 名将接受培训。 一名公共卫生硕士和 4 名将获得博士学位——这是第一批接受博士级公共卫生培训的人 海地。研究培训将重点关注以下领域的青少年健康：1) 艾滋病毒预防，2) 艾滋病毒治疗，3) 艾滋病毒和结核病合并感染，4) 艾滋病毒和非传染性疾病。 成为 GHESKIO 和海地卫生部青少年健康研究的未来领导者 健康方面，该计划还将包括研究人员的中期培训（6-12 个月）。 包括心理学家 (4)、数据管理员 (4) 和社区卫生工作者 (4)，以建立 以社区为基础的研究团队。 在海地，所有新发艾滋病毒感染者中有 50% 是青少年，其中 80% 联合国儿童基金会宣布青少年是“社会的中心”。 艾滋病毒流行”。感染艾滋病毒的青少年和青年的抗逆转录病毒治疗效果不佳。 一年后，只有 50% 的患者继续接受护理，而 90% 的患者仍继续接受护理 成人10岁至24岁是结核病感染的高峰期。 此外，只有 40% 的 HIV 感染青少年患有结核病培养阳性。 最终成功完成青少年早发性高血压的治疗。 海地的年轻人的比例是同等年龄的美国黑人的 12% - 3 倍。 开发和验证基于社区的方法来识别、参与和 让青少年继续接受护理将导致健康结果的可持续改善 该计划响应海地卫生部的优先事项，并将培训 下一代海地领导人开展基于社区的青少年艾滋病毒研究。