Modular Adaptive Virtual Reality Intervention for Clinical Substance use disorder (MAVRICS)

临床药物使用障碍的模块化自适应虚拟现实干预 (MAVRICS)

• 批准号: 10542645
• 负责人: Michelle (Micki) E Washburn
• 金额: $ 5.5万
• 依托单位: INNATEVR, LLC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10542645
• 关键词: Acute; Address; Ambulatory Care; Behavior Therapy; Behavioral; Child Welfare; Chronic; Client; Clinical; Computer software; Cues; Custom; Emergency Care; Environment; Exposure to; HIV Infections; HIV/HCV; Impairment; Individual; Intervention; Interview; Justice; Left; Mental Health; Methods; Neonatal Abstinence Syndrome; Probability; Public Health; Relapse; Research; Residential Treatment; Risk; Series; Software Tools; Substance Use Disorder; System; Testing; Time; Update; base; craving; design; disorder later incidence prevention; experience; improved; mortality; novel; opioid use disorder; physical conditioning; premature; programs; substance misuse; substance use; virtual; virtual environment; virtual reality; virtual reality intervention

PROJECT SUMMARY/ABSTRACT Opioid Use Disorder (OUD) is a chronic, recurring condition that if left untreated, poses a significant and ongoing public health threat. OUD is associated with significant impairments in physical and psychological health including increased mortality and high utilization of emergency medical care as well as increased risk of Hepatitis C and HIV infection and Neonatal Abstinence Syndrome (NAS). OUD is also associated with increased justice and child welfare systems involvement. Currently, the number of empirically supported behavioral interventions for the treatment of OUDs is limited, the majority of which cannot be tailored (customized) to meet the unique needs of the individual client. As such, the relapse rate for individuals with OUDs remains high. Virtual reality cue exposure (VRCE) has shown considerable promise in addressing substance craving, one of the most salient components of OUD. Through repeated exposure to substance use cues within a controlled virtual environment, over time these virtual exposures weaken the relationship between substance use cues and craving, potentially leading to decreased substance use and lower probability of substance relapse. Unfortunately, currently available commercial VR products lack the essential ability to easily and repeatedly update exposure environments to introduce novelty or incorporate new or evolving substance use cues. This limitation results in less user engagement over time, potentially leading to user disengagement and premature treatment termination. Through the R41 project titled “Modular Adaptive Virtual Reality Intervention for Clinical Substance use disorder (MAVRICS)”, the research aims to improve upon currently available commercial virtual reality (VR) products designed to address substance misuse by developing a novel subscription-based software product (Helix) that supports ongoing customization of virtual reality-based cue exposure (VRCE) environments resulting in a tailored intervention addressing substance craving. Through the I-Corp program, the commercial potential for Helix will be further explored and five hypotheses pertaining to various commercial aspect of Helix will be tested through a series of interviews with potential customers and experts in the field of OUD treatment.

项目概要/摘要 阿片类药物使用障碍 (OUD) 是一种慢性、反复发作的疾病，如果不及时治疗，会造成严重的后果 持续的公共健康威胁与身体和身体的严重损害有关。 心理健康，包括死亡率增加和紧急医疗护理的高利用率以及 丙型肝炎和艾滋病毒感染以及新生儿戒断综合症（OUD）的风险也会增加。 目前，从经验来看，与司法和儿童福利系统参与的增加有关。 用于治疗 OUD 的受支持的行为干预措施有限，其中大多数无法量身定制 （定制）以满足个人客户的独特需求因此，个人的复发率。 OUD 仍然很高。 虚拟现实提示暴露（VRCE）在解决物质渴望方面显示出巨大的前景，这是解决物质渴望的方法之一。 OUD 最显着的组成部分是通过在受控的范围内反复接触物质使用线索。 虚拟环境，随着时间的推移，这些虚拟暴露会削弱物质使用线索之间的关系 和渴望，可能会导致药物使用减少和药物复发的可能性降低。 不幸的是，目前可用的商业 VR 产品缺乏简单、重复的必要能力 更新暴露环境以引入新颖性或纳入新的或不断变化的物质使用线索。 随着时间的推移，限制会导致用户参与度降低，从而可能导致用户脱离并过早地 治疗终止。 通过名为“临床药物使用的模块化自适应虚拟现实干预”的 R41 项目 障碍（MAVRICS）”，该研究旨在改进目前可用的商业虚拟现实（VR） 旨在通过开发新颖的基于订阅的软件产品来解决药物滥用问题的产品 (Helix)，支持基于虚拟现实的线索曝光 (VRCE) 环境的持续定制 通过 I-Corp 计划，针对物质渴望采取量身定制的干预措施。 将进一步探索 Helix 的潜力，并提出与 Helix 的各个商业方面有关的五个假设 将通过对 OUD 处理领域的潜在客户和专家的一系列采访进行测试。