Epithelial Stem Cells and their Niches

上皮干细胞及其生态位

• 批准号: 10540500
• 负责人: Valerie Horsley
• 金额: $ 3万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10540500
• 关键词: Acute; Adult; Aging; Animal Model; Animals; Area; Asia; Australia; Biological Models; Biology; Biomedical Engineering; COVID-19; Cells; China; Clinic; Collaborations; Communication; Complex; Cornea; DNA Repair; Data; Development; Disease; Disease model; Environment; Epidermis; Epithelial; Epithelial Cells; Europe; Fertilization; Floor; Fostering; Generations; Goals; Growth; Homeostasis; Hong Kong; Human; Image; India; Injury; Intestines; Japan; Korea; Life; Location; Lung; Malignant Neoplasms; Mammary gland; Medical; Mission; Molecular; Mus; Oral; Organ; Organism; Organoids; Participant; Postdoctoral Fellow; Prostate; Regenerative Medicine; Regulation; Regulatory Pathway; Research; Research Personnel; Scientist; Signal Transduction; Singapore; Skin; Source; Stem Cell Research; Stomach; Structure; Students; System; Systems Biology; Techniques; Technology; Tissue Engineering; Tissues; Training; Transplantation; Work; appendage; career; cell type; comparative; craniofacial complex; epigenetic regulation; epithelial stem cell; epithelium regeneration; field study; fighting; graduate student; immunoregulation; in vivo; injury and repair; interest; meetings; news; next generation; peer; posters; programs; regenerative; repaired; self-renewal; single cell analysis; stem cell function; stem cells; symposium; synergism; three dimensional cell culture; tissue stem cells

Abstract Adult epithelia regenerate during adult life due to the constant activity of stem cell pools. Stem cells maintain tissue homeostasis and repair injury by close communication with their tissue environment, known as "niche". Niches are complex, structured arrays of different cell types that guide tissue stem cell dynamics. The ultimate goal of understanding epithelial stem cell regulation is to repair or replace cells or organs damaged by injury, disease, and aging. The strategies vary from generating cell types and tissues in a dish for transplantation purposes, to directly stimulating the damaged organ in the living organism. This field has been exponentially growing for the past decade. Tissues such as human skin and cornea have already been grown in 3D cultures and used in clinics to fight otherwise incurable medical conditions. The GRC "Epithelial Stem Cells and their Niches” will focus on comparative principles of adult epithelial stem cell dynamics and niche signaling in the homeostasis of different tissues. This conference will include work on the molecular control of stem cell function from the epidermis and its appendages, intestine, lung, mammary gland, cornea, prostate, and emerging work from other epithelial tissues. All model organisms are welcome. This GRC has held two meetings in 2016 and 2018 and was cancelled in 2020 due to COVID-19. We hope to continue to build a principle of alternating speakers that will allow a variety of participants to contribute to this exciting meeting over the coming years. In particular for the 2022 meeting, we have built a scientific program that emphasizes key cutting-edge areas in epithelial biology including organoid techniques, imaging and single cell analysis, bioengineering, systems biology, modeling disease, DNA repair, aging and epigenetic regulation. In addition, we will support the attendance of graduate students, post docs, and early career scientists as they make their way into this exciting field of study by hosting a GRS in the two days prior to this GRC. A critical feature of the GRC’s scientific mission is to engage the next generation of scientists. We are introducing a two-day Gordon Research Seminar (GRS) for graduate students and postdoctoral fellows that will precede this GRC. The GRS will allow students and fellows to share and discuss unpublished data and technical breakthroughs, favouring collaborative efforts and sparking provocative hypotheses to be discussed on the floor of the main conference. Furthermore, the participants will have the opportunity to establish tight professional relationships from which they will benefit throughout their career. GRS participants will be expected to stay for the GRC, further contributing to the educational value of this conference.

抽象的 由于干细胞的持续活性，成体上皮在成年期间再生 干细胞通过密切维持组织稳态并修复损伤。 与其组织环境的沟通，称为“生态位”，是复杂的， 指导组织干细胞动力学的不同细胞类型的结构化阵列。 了解上皮干细胞调节的最终目标是修复或替代 因损伤、疾病和衰老而受损的细胞或器官的策略各不相同。 在培养皿中生成用于移植目的的细胞类型和组织，以直接 刺激生物体中受损的器官。 人类皮肤和角膜等组织在过去十年呈指数级增长。 已经在 3D 培养物中生长并用于诊所以对抗其他无法治愈的疾病 GRC“上皮干细胞及其生态位”将重点关注医疗条件。 成体上皮干细胞动力学和生态位信号传导的比较原理 本次会议将包括关于不同组织的稳态的工作。 表皮及其附属物对干细胞功能的分子控制， 肠、肺、乳腺、角膜、前列腺以及其他领域的新兴工作 欢迎所有模型生物参加。本次 GRC 已召开了两次会议。 2016 年和 2018 年举办，并于 2020 年因 COVID-19 取消。 建立交替发言者的原则，使不同的参与者能够 在未来几年，特别是 2022 年，为这次激动人心的会议做出贡献。 会议上，我们制定了一个强调关键前沿领域的科学计划 上皮生物学，包括类器官技术、成像和单细胞分析， 生物工程、系统生物学、疾病建模、DNA 修复、衰老和表观遗传学 此外，我们还将支持研究生、博士后、 和早期职业科学家，因为他们进入了这个令人兴奋的研究领域 在 GRC 之前的两天举办 GRS。 GRC 科学使命的一个重要特点是让下一代参与 我们正在为科学家们推出为期两天的戈登研究研讨会（GRS）。 GRS 之前的研究生和博士后研究员。 允许学生和研究员分享和讨论未发表的数据和技术 突破，有利于协作努力并引发挑衅性假设 将在主会议上进行讨论。此外，与会者 将有机会建立紧密的专业关系，从中他们 GRS 参与者将始终受益于他们的职业生涯。 GRC，进一步提升了本次会议的教育价值。