2022 Conference: Clinical and Scientific Advances in Urinary Tract Infections

2022 年会议：尿路感染的临床和科学进展

基本信息

批准号：
10540602
负责人：
Christina B Ching
金额：
$ 0.25万
依托单位：
RESEARCH INST NATIONWIDE CHILDREN'S HOSP
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10540602
关键词：
Acute Adult Antibiotic Resistance Antibiotic Therapy Antibiotics Area Bacterial Antibiotic Resistance Basic Science Buffaloes Caring Characteristics Child Childhood Clinical Clinical Management Clinical Pathology Clinical Research Collaborations Communicable Diseases Complex Diagnosis Discipline Discipline of Nursing Discipline of obstetrics Disease Doctor of Philosophy Elderly Emergency Medicine Emergency department visit End stage renal failure Ensure Faculty Fostering Future Geriatrics Government Agencies Health Hospitalization Human Hypersensitivity Hypertension Immunology Industrialization Infection Institutes International Investments Justice Lead Low Birth Weight Infant Medical Medicine Microbiology Mission National Institute of Diabetes and Digestive and Kidney Diseases Nephrology New York Ohio Outcome Outpatients Pathogenesis Patients Pediatrics Physician Executives Practice Management Predisposition Pregnancy Premature Birth Prevention Principal Investigator Queensland Recovery Recurrence Research Research Personnel Science Scientific Advances and Accomplishments Scientific Inquiry Scientist Secure Sepsis Series Sex Differences Therapeutic Training Underrepresented Populations United States Universities Urinary tract Urinary tract infection Urologic Diseases Urology Visit Washington Woman adverse pregnancy outcome age difference alternative treatment base bench to bedside beta-Lactams biomedical scientist career catheter associated UTI clinical conference clinical practice clinically relevant comorbidity disability insight interest medical schools medical specialties meetings mental state mid-career faculty mortality multidisciplinary next generation novel diagnostics novel therapeutic intervention patient population prevent professor recruit renal scarring side effect socioeconomics symposium trait translational approach translational health science

项目摘要

ABSTRACT Urinary tract infections are a significant socioeconomic burden afflicting 150 million patients worldwide each year, most of whom are healthy adult women. The high rate of antibiotic usage to treat acute and recurrent episodes of urinary tract infection has led to a dramatic increase in the number of infections caused by antibiotic resistant bacteria including extended spectrum beta- lactam producing strains. The decrease in availability of efficacious antibiotic therapies has elevated the need to accelerate all aspects of UTI research as outlined in our programmatic topic areas. This conference goes beyond the exchange of basic science findings and strive for a clinical relevance of research findings as they can be applied to clinical practice as well as using clinical challenges to foster new collaborations and experimental approaches. Although healthy women represent the majority of patients treated for urinary tract infection, we will target previously under investigated areas such as sex and age differences, susceptibility factors and negative sequelae. Further, this conference provides clinicians across specialties (such as pediatrics, geriatrics, obstetrics, complex care, emergency medicine, urology, and nephrology) the opportunity to brainstorm treatment approaches with each other and to communicate their needs for research directly to researchers, informing future lines of scientific inquiry. By focusing holistically on the disease of UTI rather than on any one research or clinical approach, discussions and collaborations can cross from the bench to the bedside. As part of a long-term plan for preventing and managing UTI, we also have a training mission to recruit and support early career researchers and those not traditionally represented in medicine and research as they transition into the next generations of experts.

抽象的尿路感染是困扰 1.5 亿患者的重大社会经济负担每年在世界范围内，其中大多数是健康的成年女性。抗生素使用率高治疗急性和复发性尿路感染导致尿路感染的急剧增加由抗生素耐药细菌引起的感染数量，包括广谱β- 内酰胺生产菌株。有效抗生素疗法的可用性下降加剧正如我们的规划主题领域所述，需要加速尿路感染研究的各个方面。这次会议超越了基础科学成果的交流，力求临床研究结果的相关性，因为它们可以应用于临床实践以及使用临床促进新的合作和实验方法的挑战。虽然健康的女性代表大多数接受尿路感染治疗的患者，我们将之前的目标定位为调查了性别和年龄差异、易感因素和不良后遗症等领域。此外，本次会议还为跨专业的临床医生（例如儿科、老年病学、产科、综合护理、急诊医学、泌尿科和肾脏科）有机会互相集思广益的治疗方法并交流他们的研究需求直接向研究人员提供信息，为未来的科学探究提供信息。通过全面关注尿路感染疾病，而不是任何一项研究或临床方法、讨论和合作可以从长凳跨越到床边。作为预防和管理长期计划的一部分 UTI，我们还有一个培训任务来招募和支持早期职业研究人员和那些非传统上代表医学和研究，因为他们过渡到下一代专家。