Neuroimmunometabolism: Obesity at the Crossroads between Neuroimmunity and Immunometabolism

神经免疫代谢：神经免疫和免疫代谢十字路口的肥胖

• 批准号: 10540258
• 负责人: Thale Cross Jarvis
• 金额: $ 2.01万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10540258
• 关键词: Address; Adipose tissue; Area; Autonomic nervous system; Blood - brain barrier anatomy; Brain; Cells; Collaborations; Colorado; Conflict (Psychology); Disease; Drug Delivery Systems; Educational workshop; Fatty acid glycerol esters; Future; Goals; Heart Diseases; Hypothalamic structure; Immune; Immunobiology; Immunomodulators; Industrialization; Inflammation; Knowledge; Learning; Liver; Malignant Neoplasms; Metabolic; Metabolism; Methodology; Modeling; Nerve; Nerve Degeneration; Neural Pathways; Neurodegenerative Disorders; Neuroimmune; Neuroimmunomodulation; Neurons; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Obesity associated disease; Organ; Outcome; Output; Overweight; Pancreas; Pathway interactions; Persons; Pharmacological Treatment; Pharmacology; Physiology; Research; Research Personnel; Scientist; Speed; Technology; Therapeutic; Translations; Work; career; clinical implementation; clinical practice; design; fighting; interdisciplinary approach; interdisciplinary collaboration; interest; learning network; multidisciplinary; next generation; nonalcoholic steatohepatitis; obesity treatment; posters; preservation; symposium

ABSTRACT Support is requested for a Keystone Symposia conference entitled Neuroimmunometabolism: Obesity at the Crossroads between Neuroimmunity and Immunometabolism, organized by Drs. Ana Domingos and Alan Saltiel. The conference will be held in Breckenridge, Colorado from October 7-10, 2022. Adiposity is governed by hypothalamus-organ neuronal pathways, particularly by sympathetic nerves in the liver and adipose tissue that degenerate during the onset of obesity. Metabolic inflammation can prompt neurodegenerative mechanisms within the autonomic nervous system or hypothalamus to worsen metabolic outcomes. A deeper understanding of the neuroimmune aspects that regulate immunometabolism may change the way we think about pharmacologically targeting NASH and obesity. Whereas drug delivery across the blood-brain barrier is a real challenge, targeting nerve-associated immune cells that modulate the output of nerves within the liver, pancreas, or fat is a tangible approach. However, this possibility relies on filling the knowledge gap on the neuroimmune mechanisms governing the physiology of the liver, pancreas, brown and white adipose tissues. The neuroimmune understanding of gut physiology has taken great strides that could have parallels within the immunometabolism field. The opportunity presented by the newly recognized intersections between the fields of neuroimmunity and immunometabolism is gigantic and may create new scientific knowledge and therapeutic advances.

抽象的 请求支持题为“神经免疫代谢：肥胖”的 Keystone 研讨会 神经免疫和免疫代谢之间的十字路口，由博士组织。安娜·多明戈斯和艾伦 萨尔蒂尔。会议将于2022年10月7日至10日在科罗拉多州布雷肯里奇举行。 肥胖是由下丘脑器官神经元通路控制的，特别是由下丘脑中的交感神经控制。 肥胖发作期间退化的肝脏和脂肪组织。代谢性炎症可提示 自主神经系统或下丘脑内的神经退行性机制导致代谢恶化 结果。对调节免疫代谢的神经免疫方面的更深入了解可能会 改变我们对针对 NASH 和肥胖的药物治疗的思考方式。而药物输送跨 血脑屏障是一个真正的挑战，它针对调节神经输出的神经相关免疫细胞 肝脏、胰腺或脂肪内的神经是一种有形的方法。然而，这种可能性依赖于填充 关于控制肝脏、胰腺、棕色和肝脏生理学的神经免疫机制的知识差距 白色脂肪组织。对肠道生理学的神经免疫理解已经取得了长足的进步，可以 在免疫代谢领域有相似之处。新认可带来的机会 神经免疫和免疫代谢领域之间的交叉点是巨大的，可能会创造新的 科学知识和治疗进展。