2022 International Lymphangioleiomyomatosis (LAM) Research Conference

2022年国际淋巴管平滑肌瘤病（LAM）研究会议

• 批准号: 10539078
• 负责人: Nishant Gupta
• 金额: $ 4万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-10 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10539078
• 关键词: Address; Advisory Committees; Appointment; Area; Attention; Award; Biology; COVID-19; COVID-19 pandemic; Chicago; Chronic; Clinic; Clinical; Clinical Investigator; Clinical Management; Clinical Trials; Clinical Trials Design; Collaborations; Communities; Complement; Congresses; Conscious; Country; Diffuse; Discipline; Disease; Disease remission; Dissection; Dyspnea; Ensure; Estrogens; Exertion; FDA approved; FRAP1 gene; Family; Family member; Female; Foundations; Friends; Friendships; Future; Genes; Goals; Grant; Guidelines; Hares; Health; Image; Imaging Techniques; Immersion; Immunotherapy; Individual; International; Interstitial Lung Diseases; Life; Lung; Lung diseases; Lymphangiogenesis; Lymphangioleiomyomatosis; Lymphatic; Metabolism; Mind; Molecular; Molecular Target; Molecular and Cellular Biology; Monitor; Multicenter Studies; Mutation; Oral; Pathogenesis; Pathway interactions; Patient-Focused Outcomes; Patients; Persons; Phase; Physicians; Pleural Diseases; Procedures; Quality of life; Randomized; Readiness; Recurrence; Research; Research Design; Research Personnel; Respiratory Failure; Role; Science; Scientific Advances and Accomplishments; Scientist; Series; Signal Transduction; Sirolimus; Smooth Muscle; Social Distance; Symptoms; Therapeutic; Therapeutic Trials; Time; Translating; Travel; Tuberous Sclerosis; Underrepresented Minority; Uterus; Vaccinee; Woman; Work; authority; base; career; cell growth; clinical biomarkers; clinical care; clinical investigation; clinical practice; design; diversity and inclusion; double-blind placebo controlled trial; ethnic diversity; experience; gender diversity; gene product; improved; innovation; interest; mTOR Inhibitor; meetings; metabolomics; next generation; novel; novel strategies; novel therapeutics; patient oriented; patient safety; peer coaching; posters; programs; pulmonary function decline; racial diversity; recruit; single-cell RNA sequencing; social; success; symposium; synergism; tumor microenvironment

Project Summary Our purpose is to: 1) Review exciting advances in single cell RNAseq estrogen/uterine signaling, immunotherapy and metabolic processes that are relevant to LAM, 2) Provide a forum for LAM Clinic Directors to promote best practices, refine LAM Guidelines, discuss difficult cases, and set priorities, 3) Set the stage for sustainable scientific progress by encouraging and nurturing the early career researchers (ECRs), and 4) Enable full immersion and integration of patients and families into all facets of the symposium to design research that addresses their priorities. The meeting will completely occupy the Hilton Rosemont in Chicago, a conference facility and hotel within two miles of Chicago O’Hare Airport. ECRs will be encouraged by prioritizing speaker slots, travel and lodging reimbursement, and arranging an exclusive ECR social following the poster session. Active engagement with peers, mentors, and patients will introduce young scientists to the joys of a career in goal oriented, disease-focused research and help recruit and retain them to study LAM. Four half-day plenary sessions composed of invited speakers and platform presentations from selected abstracts will form the core of the meeting on Friday and Saturday. The basic and translational focus of the meeting will be on improved understanding of the tumor microenvironment, and identification of molecular targets and clinically useful biomarkers, using novel approaches that include advanced imaging, single cell RNA sequencing, metabolomics and clues from known intersection of mTOR signaling with uterine/estrogen biology. A poster session and discussion focused to junior investigators will be held on Friday afternoon. Clinical talks will be incorporated into most sessions to hold the attention of an audience with diverse areas of interest and expertise. A concurrent patient-oriented seminar series will address key issues for ~200 LAM patients and family members, culminating in a summary of scientific sessions by the conference chairs on Sunday. A LAM Clinic Directors meeting will be convened on Friday evening to discuss challenging cases and set priorities for the network. Each session will be chaired by an expert and include invited speakers as well as speakers chosen from submitted abstracts, with a focus on ECR recruitment. There has been a conscious effort to attract diverse investigators from related disciplines who can complement the expertise of LAM investigators. Discussions facilitated by an experienced leader/moderator will be an importantcomponent of all sessions. Outstanding ECRs will be awarded travel grants based on merit and will begiven the opportunity to present their research in platform and poster formats. Specific attention will be given to ensure the speaker portfolio represents gender, racial and ethnic diversity. In summary, our goal is to provide a forum for experts to discuss the molecular and cellular basis of LAM, review the clinical management of LAM, to present cutting edge research, integrate concepts, identify creative and innovative research directions, and ultimately, improve the health and quality of life of patients with LAM.

项目概要 我们的目的是： 1) 回顾单细胞 RNAseq 雌激素/子宫信号传导、免疫治疗方面令人兴奋的进展 和与 LAM 相关的代谢过程，2) 为 LAM 诊所主任提供一个论坛，以促进最佳 实践，完善 LAM 指南，讨论困难案例并确定优先事项，3) 为可持续发展奠定基础 通过鼓励和培养早期职业研究人员 (ECR) 来促进科学进步，以及 4) 充分利用 让患者和家属沉浸并融入研讨会的各个方面，以设计研究 他们的会议重点将完全占据芝加哥罗斯蒙特希尔顿酒店的会议。 芝加哥奥黑尔机场两英里内的设施和酒店将受到优先发言者的鼓励。 时间、旅行和住宿报销，并在海报会议后安排独家 ECR 社交活动。 与同行、导师和患者的积极互动将使年轻科学家享受职业生涯的乐趣 以目标为导向、以疾病为重点的研究，并帮助招募和留住他们来学习 LAM 四次半天的全体会议。 由受邀演讲者和选定摘要的平台演示组成的会议将构成 周五和周六的会议的基本重点和转化重点将是改进。 了解肿瘤微环境，识别分子靶点并具有临床意义 生物标志物，使用先进成像、单细胞 RNA 测序、代谢组学等新方法 以及来自已知的 mTOR 信号与子宫/雌激素生物学交叉的线索。 周五下午将针对初级研究人员进行讨论，并将其纳入临床讨论中。 大多数会议能够同时吸引具有不同兴趣和专业知识领域的观众的注意力。 以患者为中心的系列研讨会将解决约 200 名 LAM 患者及其家属的关键问题，最终 会议主席将于周日举行 A LAM 诊所主任会议的科学会议总结。 周五晚上召开会议，讨论具有挑战性的案例并确定网络的优先事项。 由一名专家主持，包括受邀演讲者以及从提交的摘要中选出的演讲者， 重点关注 ECR 招募。我们有意识地努力吸引来自相关领域的不同研究人员。 可以补充 LAM 研究人员专业知识的学科 由经验丰富的专家主持讨论。 领导者/主持人将成为所有会议的重要组成部分，将获得差旅补助。 基于优点，并将有机会以平台和海报形式展示他们的研究。 将注意确保演讲者组合代表性别、种族和民族多样性。 总之，我们的目标是为专家提供一个论坛来讨论 LAM 的分子和细胞基础， 回顾 LAM 的临床管理，展示前沿研究，整合概念，识别创意 和创新的研究方向，最终改善 LAM 患者的健康和生活质量。