PHASE I AND PHARMACOKINETIC STUDIES OF ANTICANCER AGENTS

抗癌药物的 I 期研究和药代动力学研究

• 批准号: 3607867
• 负责人: RONALD L RICHARDSON
• 金额: $ 15.84万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-05-01 至 1995-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3607867
• 关键词: antineoplastics; clinical trials; drug adverse effect; drug metabolism; human subject; human therapy evaluation; neoplasm /cancer chemotherapy; neoplasm /cancer pharmacology

The specific objectives of this contract are: 1) to define the acute toxicities of new anticancer agents in patients with advanced cancer; 2) to redefine the acute toxicities and pharmacokinetics of anticancer administered in combination with agents to modulate toxicity or antitumor effect; 3) to provide information on the pharmacokinetic characteristics (absorption, distribution, metabolism and elimination) and pharmacodynamics of selected antitumor agents; and 4) to determine a treatment regimen suitable for evaluation of antitumor activity in Phase II trials.

本合同的具体目标是： 1) 定义急性 新抗癌药物对晚期癌症患者的毒性； 2） 重新定义抗癌药物的急性毒性和药代动力学 与调节毒性或抗肿瘤药物联合施用 影响; 3) 提供药代动力学特征信息 （吸收、分布、代谢和消除）和 所选抗肿瘤药物的药效学； 4) 确定 适用于阶段性抗肿瘤活性评估的治疗方案 二试。