RESYNTHESIS OF COMPOUNDS FOR SCREENING

用于筛选的化合物的再合成

• 批准号: 3609384
• 负责人: HERBERT H SELTZMAN
• 金额: $ 26.46万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-10-07 至 1994-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3609384
• 关键词: antiAIDS agent; antineoplastics; chemical stability; drug classification; drug design /synthesis /production; drug screening /evaluation; solubility

Compounds identified by the Drug Synthesis and Chemistry and Chemistry Branch for testing in the NCI's anti HIV and antitumor screens consist variously of voluntarily donated compounds and those which are requested from their authors from the published recent literature on the basis of their structural novelty or relevance. Compounds in this last category are often not available to the program. Situations also arise where follow up testing of a lead is precluded by the fact that the original donor cannot provide additional sample or a small series of structurally related compounds. This service project provides for the preparation of these organic or inorganic compounds required by the screening and development programs. As many as 200 compounds may be assigned to the contractors over the life of this project. The scale of the Work will typically involve a request for samples of final compounds in the range of 100 mg to 5 grams. Specific experimental conditions from the published literature will be available in the majority of cases. Some process development may be required in instances where detailed procedures are not reliable or are unavailable. The contract mechanism is deemed the most appropriate instrument for fulfilling the requirement because: The compounds to be acquired are not stock catalogue items; successful preparation of the assigned compounds will require significant technical direction by the Project Officer. A contract allows for the acquisition of the compounds on a priority basis and time frame controlled by the Government, for the direct benefit or use of the Government.

药物合成，化学和化学鉴定的化合物 在NCI的抗HIV和抗肿瘤筛选中进行测试的分支 各种自愿捐赠的化合物和要求的化合物 从他们的作者那里发表的最新文献。 它们的结构新颖性或相关性。 最后类别中的化合物 程序通常不可用。 也出现了 原始的事实阻止了铅的后续测试 捐助者无法提供其他样本或一小部分结构 相关化合物。 该服务项目提供了准备 筛选需要的这些有机或无机化合物 开发计划。 可以将多达200种化合物分配给承包商 这个项目的生活。 工作规模通常涉及 请求最终化合物的样品在100毫克至5的范围内 克。 已发表文献的特定实验条件 将在大多数情况下可用。 一些过程开发 在详细过程不可靠的情况下可能需要 或不可用。 合同机制被视为最合适的工具 满足要求是因为： 要获得的化合物不是库存目录项目；成功的 准备分配的化合物的准备工作将需要大量的技术 项目官员的指示。 合同允许优先获得化合物 由政府控制的基础和时间范围，直接 利益或利用政府。