EXAMINATION OF INDIVIDUAL SENSITIVITY TO OPIOIDS EFFECTS

检查个人对阿片类药物影响的敏感性

• 批准号: 2118086
• 负责人: DRAKE MORGAN
• 金额: $ 1.3万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2118086
• 关键词: EXAMINATION; INDIVIDUAL; SENSITIVITY; OPIOIDS; EFFECTS

The proposed project was designed to analyze individual differences in sensitivity to various effects of opioids with low to intermediate efficacy at the mu receptor. Using the drug discrimination and tail withdrawal assays, differences in sensitivity to the discriminative stimulus, rate-decreasing, and antiociceptive effects of these drugs will be examined in Experiment I. These differential sensitivities will be compared across assays within an individual animal in order to assess the degree of cross-sensitivity to these effects. Given these large interanimal differences, Experiment II will examine the degree of antagonism by naloxone, to determine whether these differences are due to interactions with separate populations of receptors across animals. Finally, the development of tolerance will be examined to see if differential magnitudes of tolerance become apparent across animals in Experiment III. The results of these studies will provide insight into the mechanisms by which individual differences in sensitivity to the effects of opioids are mediated and may help identify some of the environmental, genetic, and pharmacological influences which interact to produce these interanimal differences.

拟议的项目旨在分析个人差异 对低至中间的阿片类药物的各种作用的敏感性 MU受体的功效。 使用药物歧视和尾巴 提取测定，对歧视性的敏感性差异 这些药物的刺激，减轻速率和抗伤害感受效应将 在实验I中进行检查。这些差异敏感性将是 比较单个动物内的测定法，以评估 对这些影响的交叉敏感性程度。 鉴于这些很大 间差异差异，实验II将检查 纳洛酮对拮抗作用，以确定这些差异是否应到期 与动物跨动物的单独受体种群的相互作用。 最后，将检查宽容的发展，以查看是否是否 耐受性的差异在各种动物中变得显而易见 实验III。 这些研究的结果将为您洞悉 个体对敏感性敏感性差异的机制 阿片类药物的作用是介导的，可能有助于确定一些 与环境，遗传和药理影响相互作用 产生这些无限差异。