FUNCTIONAL STRUCTURE & INFORMATION PROCESSING IN CORTEX

功能结构

• 批准号: 2293229
• 负责人: JITENDRA SHARMA
• 金额: $ 3.12万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2293229
• 关键词: FUNCTIONAL; STRUCTURE; INFORMATION; PROCESSING; CORTEX

A basic question in understanding the development and plasticity of the brain is: what determines the functional specificity of a structure during development? Recent investigations suggest that many fundamental features of sensory cortex are regulated developmentally by the pattern of their input activity. It has been demonstrated that single cells in auditory cortex can be made visually responsible by routing, through appropriate surgery, their retinal projections into auditory cortical targets. It is now proposed to demonstrate experimentally that global features, for example orientation selective patches and ocular dominance columns, typical of visual cortex develop in auditory cortex of such rewired animals. Retinal projections in newborn ferret kits will be routed into the auditory thalamus (MGN) by surgically ablating central retinal targets and by creating alternative terminal space in MGN. After rearing to adulthood intect cortex in these animals will be optically mapped for their intrinsic signals' generated in response to specific visual stimuli. Signals will be digitally processed and compared with those of visual cortex of normal ferrets. In addition, it is proposed to mathematically model generation of columnar geometry in 'visually responsive' auditory cortex of rewired animals and predict its role in visual signal processing.

了解理解的发展和可塑性的基本问题 大脑是：什么决定结构的功能特异性 在开发过程中？ 最近的调查表明许多基本 感觉皮层的特征通过模式在发育中调节 他们的输入活动。 已经证明了 通过路由，通过路由，可以使听觉皮层通过 适当的手术，其视网膜预测到听觉皮层 目标。 现在建议通过实验证明全球 特征，例如方向选择性补丁和眼部优势 列，典型的视觉皮层在这种听觉皮层中发展 重新连接的动物。 新生雪貂套件中的视网膜预测将是 通过外科手术擦拭中心，进入听觉丘脑（MGN） 视网膜目标并通过在MGN中创建替代终端空间。 后 这些动物的成年饲养型含皮层将是光学的 根据特定的特定信号生成的固有信号映射 视觉刺激。 信号将进行数字处理，并将 正常雪貂的视觉皮层。 另外，提出了 以视觉上的数学形式建模圆柱几何形状的生成 反应敏感的“重新接线动物的听觉皮层”，并预测其在 视觉信号处理。