The targeting of macromolecules to alter mitochondrial function

大分子靶向改变线粒体功能

• 批准号: DP150100293
• 负责人: A/Prof Monika Murcha
• 金额: $ 21.09万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150100293
• 关键词: targeting; macromolecules; alter; mitochondrial; function

Mitochondria are essential organelles involved in energy production and specific metabolic pathways in plant cells that require the import of cytosolic transfer RNA (tRNA) to function. To date our knowledge on the mechanisms of tRNA import is limited. This project seeks to characterise putative receptors and mechanisms with the purpose of exploiting these insights to allow for the manipulation and modification of macromolecule targeting to mitochondria. The ability to modify or alter mitochondrial biogenesis and activity may allow for new approaches to be undertaken to increase plant growth, productivity and resistance to stress.

线粒体是参与植物细胞能量产生和特定代谢途径的重要细胞器，需要导入胞质转移 RNA (tRNA) 才能发挥作用。迄今为止，我们对 tRNA 输入机制的了解还很有限。该项目旨在描述假定的受体和机制，目的是利用这些见解来操纵和修饰靶向线粒体的大分子。修饰或改变线粒体生物发生和活性的能力可能允许采用新方法来提高植物生长、生产力和抗逆性。