Alpha oscillations and working memory deficits in ADHD: A multimodal imaging investigation

ADHD 中的阿尔法振荡和工作记忆缺陷：多模态成像研究

基本信息

批准号：
10515331
负责人：
Agatha Lenartowicz
金额：
$ 67.73万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-11-06 至 2024-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10515331
关键词：
18 year old Academic achievement Acceleration Address Adolescence Adolescent Age Attention Attention deficit hyperactivity disorder Attentional deficit Behavioral Behavioral Assay Biological Biological Markers Brain Characteristics Child Clinical Cognitive Data Data Set Development Diagnosis Diagnostic Dissociation Electroencephalography Event Functional Magnetic Resonance Imaging Goals Heterogeneity High Prevalence Hyperactivity Individual Investigation Life Link Longitudinal Studies Magnetic Resonance Measures Mediating Memory impairment Methodology Multimodal Imaging Nature Occipital lobe Outcome Outcomes Research Participant Patients Performance Process Quality of life Research Sampling Short-Term Memory Source Specificity Standardization Stimulus Structure Symptoms Testing Thalamic structure Time Translating Visual Cortex Visual attention Work candidate identification effective therapy experimental study follow-up improved inattention indexing innovation insight memory encoding neural neural correlate neuroimaging neuromechanism neurophysiology neuropsychiatric disorder novel recruit response societal costs

项目摘要

Project Summary High prevalence rates of attention deficit hyperactivity disorder (ADHD) (5-11% of children 4-17 years), combined with its high societal cost, strong persistence and pernicious effects on quality of life, warrant continued efforts to understand its underlying neural mechanisms. Underscoring this need is the increasing recognition that ADHD is clinically and mechanistically heterogeneous, and that this likely degrades the reliability of putative biomarkers of ADHD. Novel, focused studies that aim to reduce such heterogeneity are needed. In this project, we aim to define a robust, relatively unexplored putative biomarker of visual attention deficits, alpha range (8-12Hz) event-related decrease (ERD), which strongly indexes working memory (WM) deficits in ADHD. Using cutting-edge, concurrent EEG-fMRI recordings, we propose to measure event-related alpha ERD and its associated brain activation and network connectivity during WM encoding. The concurrent recordings allow us to directly test if fluctuations in engagement of attention mechanisms captured by the alpha ERD neurophysiological measures predict fluctuations in WM neural processes. Using this methodology, we aim to: (a) identify neural mechanisms underlying alpha ERD deficits and WM performance in ADHD, and (b) define the clinical features of alpha ERD deficits in ADHD, including its effect on real life outcomes such as academic achievement. Unique to this project, we will sample participants who were previously tested in two large ADHD-EEG studies, recruiting them for a longitudinal follow-up experimental session if they are currently in adolescence (14-18 years). By doing so we aim to (c) characterize the developmental trajectory of attention deficits as captured by alpha ERD in ADHD, as well its impact on the trajectory of clinical and real-life outcomes. The adolescent sample will provide new insight into neural and neurophysiological characteristics of ADHD during this developmental period. The outcome of this research is a clearly defined neural mechanism, alpha ERD, that can be targeted in treatment of WM deficits in ADHD, or in other neuropsychiatric disorders.

项目概要注意力缺陷多动障碍 (ADHD) 的患病率很高（4-17 岁儿童的 5-11%），加上其高昂的社会成本、强烈的持久性以及对生活质量的有害影响，有理由继续努力了解其潜在的神经机制。日益强调这一需求的是认识到 ADHD 在临床和机制上具有异质性，这可能会降低 ADHD 假定生物标志物的可靠性。旨在减少这种异质性的新颖、重点研究是需要。在这个项目中，我们的目标是定义一个稳健的、相对未经探索的视觉注意力假定生物标志物缺陷、α 范围 (8-12Hz) 事件相关减少 (ERD)，强烈索引工作记忆 (WM) 多动症缺陷。我们建议使用尖端的并发 EEG-fMRI 记录来测量与事件相关的 WM 编码过程中的 alpha ERD 及其相关的大脑激活和网络连接。并发的录音使我们能够直接测试 alpha 捕获的注意力机制参与度是否存在波动 ERD 神经生理学测量可预测 WM 神经过程的波动。使用这种方法，我们目的是：(a) 确定 ADHD 中 alpha ERD 缺陷和 WM 表现的神经机制，以及 (b) 定义 ADHD α ERD 缺陷的临床特征，包括其对现实生活结果的影响，例如学术成就。该项目的独特之处在于，我们将对之前在两个项目中进行过测试的参与者进行抽样大型 ADHD-EEG 研究，招募他们进行纵向后续实验（如果他们目前正在研究中）青春期（14-18 岁）。通过这样做，我们的目标是 (c) 描述注意力的发展轨迹阿尔法 ERD 在 ADHD 中捕获的缺陷，以及它对临床和现实生活轨迹的影响结果。青少年样本将为了解青少年的神经和神经生理学特征提供新的见解在此发育时期的多动症。这项研究的成果是一个明确定义的神经机制， α ERD，可用于治疗 ADHD 或其他神经精神疾病中的 WM 缺陷。