GENETIC INFLUENCES ON BEHAVIORAL SENSITIVITY TO ALCOHOL

遗传对酒精行为敏感性的影响

• 批准号: 2042834
• 负责人: BRUCE C. DUDEK
• 金额: $ 8.12万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT ALBANY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-02-01 至 1999-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2042834
• 关键词: aggression; alcoholism antagonist; disease /disorder classification; ethanol; euphoria; gender difference; genetic strain; laboratory mouse; male; molecular genetics; neurobiology; neurochemistry; phenotype; pleiotropism; psychopharmacology; sedative /hypnotic; stimulant /agonist; tranquilizer

The current research on one of the hallmarks of alcohol's many actions, it's frequent biphasic effect. Low doses often produce activation of behavioral and physiological characters. The behavioral activation is variously described as a stimulant effect, euphoria, and disinhibition. Although clear resolution of dimensions is not yet available, such activating effects are now receiving focus in some genetically based theories of alcoholism, such as Cloninger's scheme of alcoholic subtypes. Type II is argued to use alcohol for these euphoriant effects, implying a genetically based sensitivity to this domain of ethanol action. Laboratory studies of behavioral activation by ethanol have shown clear genetic influences on this type of initial sensitivity. Mouse locomotor activity has been the most highly investigated phenotype for this question of ethanol activation. Data collected have already provided a convincing picture of the genetic control as a simple genetic system of a small polygenic size. Three congenic strains are being developed to facilitate studies of psychopharmacological, physiological, neurochemical, molecular genetic and other phenomenological aspects of ethanol's paradoxical low-dose stimulant-like effect. These congenic strains are three pairs of inbred strains which differ from the pair member at only those genes which control the behavioral activation phenotype (as well as a small amount of tightly linked DNA). The successful completion of their development, at generation 12, will produce tools with considerable value in studies of biological pleiotropisms of these genes, their physiological/biochemical functioning, and their molecular genetic location and identity. The coherence sensitivity to ethanol, its activational effects.

目前关于酒精许多行动标志之一的研究， 这是经常产生的双相效应。 低剂量通常会激活 行为和生理特征。 行为激活是 各种描述为刺激效果，欣快和抑制作用。 尽管尚未明确解决尺寸，但是 现在，激活效应已在某些基于遗传的基础上得到重点 酒精中毒的理论，例如克隆格的酒精亚型方案。 II型被认为将酒精用于这些欣快的效果，这意味着 对乙醇作用的这一领域的基于遗传的敏感性。 乙醇行为激活的实验室研究表明 遗传对这种初始灵敏度的影响。 鼠标运动 活动一直是最受度研究的表型 乙醇激活问题。 收集的数据已经提供了 令人信服的遗传控制图片是一个简单的遗传系统 一个小的多基因尺寸。 正在开发三种先天性菌株 促进心理药理学，生理学的研究 神经化学，分子遗传和其他现象学方面 乙醇的矛盾的低剂量刺激性效应。 这些含糊 菌株是三对近交菌株，与两对不同 仅控制行为激活的基因的成员 表型（以及少量紧密连接的DNA）。 这 成功完成他们的发展，第12代 在生物学研究中生产具有相当价值的工具 这些基因的多效性，它们的生理/生化 功能及其分子遗传位置和身份。 这 对乙醇的一致性敏感性，其活化作用。