Sudden Death Associated with Substance Use

与药物使用相关的猝死

• 批准号: 10508030
• 负责人: Faye Norby
• 金额: $ 14.12万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10508030
• 关键词: Address; Affect; Arrhythmia; Autopsy; Cardiac; Cardiovascular system; Caring; Cessation of life; Clinical; Clinical Data; Cocaine; Communities; County; Data; Drug Combinations; Drug usage; Elements; Epidemiology; Event; Familiarity; Frequencies; Funding; General Population; Goals; Grant; Heart; Heart Arrest; Home; Hypertrophic Cardiomyopathy; Individual; Infrastructure; Institutes; Investigative Reports; K-Series Research Career Programs; Knowledge; Lead; Location; Long QT Syndrome; Measures; Mental disorders; Mentored Research Scientist Development Award; Mentorship; Methods; Motivation; National Heart, Lung, and Blood Institute; Opioid; Overdose; Persons; Pharmaceutical Preparations; Pharmacoepidemiology; Phenotype; Physiologic pulse; Plasma; Population; Prevention; Prevention approach; Public Health; Publishing; Reaction Time; Records; Registries; Reporting; Research; Research Activity; Research Design; Research Personnel; Research Training; Resources; Resuscitation; Series; Sudden Death; Survival Rate; System; Toxicology; Training; Training Activity; United States; Work; base; career development; community setting; data archive; design; epidemiology study; health record; high risk population; improved; injury-related death; mortality; multimodality; non-drug; non-opioid analgesic; novel; opioid epidemic; out-of-hospital cardiac arrest; overdose death; polysubstance use; prevent; programs; prospective; psychostimulant; response; skills; substance use; survival prediction; synthetic opioid; tool

PROJECT SUMMARY Sudden cardiac arrest (SCA), a sudden catastrophic loss of the pulse, continues to be a major public health issue. A proportion of SCA events occur in persons engaging in drug use and given that drug overdose deaths are at unprecedented levels in the United States, the epidemiology of drug related SCA is changing rapidly. Recognition and characterization of drug related SCA events is critical for accurate estimates of mortality associated with drug use, and to inform public health measures, especially in the context of the ongoing opioid epidemic. This proposed study will address several of the major knowledge gaps. This K01 Career Development Award leverages the existing infrastructure and clinical data archive of two ongoing prospective community-based studies of SCA. Dr. Norby will use this data to examine the epidemiology of SCA associated with drug use, with the overall goal of improving community-based approaches to SCA prevention. This proposal aims to 1) identify opportunities that will improve survival from SCA in the setting of drug use, and 2) identify substrate-trigger factors that initiate SCA in the presence of drug use. Taken together, these aims will interface community-based surveillance and comprehensive investigative reports to fill in the epidemiology and research gaps in SCA events related to substance use. To address these research aims, Dr. Norby will assemble records and reports in these two communities for SCA cases that have previously been excluded due to evidence of drug use. The overall goal of this K01 is to inform a sequence of R series grants to further investigate the prediction and prevention of SCA, and to improve survival after an SCA event related to drug use. With the support of this K01 award, Dr. Norby will be able to pursue this goal and transition to independent investigator status through essential training and mentorship. She will gain advanced training in 1) combining multimodal health records across systems and extracting pertinent information; 2) pharmacoepi drug use research and analysis of drug-drug combination; and 3) SCA mechanisms, SCA response and care, and additionally gain familiarity with toxicology and autopsy reports. Cedars-Sinai Smidt Heart Institute provides the ideal infrastructure to complete the research and training activities. Through the proposed research, training, and career development Dr. Norby will gain the scientific and professional skills necessary to become a successful independent investigator and lead a research program that advances the field of SCA associated with drug use.

项目概要 心脏骤停（SCA），一种灾难性的突然失去脉搏的情况，仍然是一个主要的公共卫生问题 问题。部分 SCA 事件发生在吸毒者身上，并且考虑到药物过量 美国的死亡人数达到前所未有的水平，与药物相关的 SCA 的流行病学正在发生变化 迅速。药物相关 SCA 事件的识别和表征对于准确估计 SCA 事件至关重要 与吸毒相关的死亡率，并为公共卫生措施提供信息，特别是在 持续的阿片类药物流行。这项拟议的研究将解决几个主要的知识差距。这个K01 职业发展奖利用了两个正在进行的现有基础设施和临床数据档案 基于社区的 SCA 前瞻性研究。诺比博士将利用这些数据来研究流行病学 SCA 与吸毒相关，总体目标是改进基于社区的 SCA 方法 预防。该提案的目的是 1) 确定提高 SCA 生存率的机会 药物使用情况，2) 确定在药物使用情况下引发 SCA 的底物触发因素。 总而言之，这些目标将把基于社区的监测和综合调查结合起来 报告填补了与物质使用相关的 SCA 事件的流行病学和研究空白。致地址 为了实现这些研究目标，Norby 博士将收集这两个社区 SCA 病例的记录和报告 之前因吸毒证据而被排除在外。 K01 的总体目标是告知 一系列 R 系列拨款，以进一步研究 SCA 的预测和预防，并改进 与吸毒相关的 SCA 事件后的生存率。在这个 K01 奖的支持下，Norby 博士将能够 通过必要的培训和培训来实现这一目标并过渡到独立调查员身份 指导。她将获得以下方面的高级培训：1) 跨系统结合多模式健康记录 并提取相关信息； 2）pharmacoepi药物使用研究与药物分析 组合; 3) SCA 机制、SCA 反应和护理，并另外熟悉 毒理学和尸检报告。 Cedars-Sinai Smidt 心脏研究所提供了理想的基础设施 完成研究和培训活动。通过拟议的研究、培训和职业生涯 诺比博士将获得成为一名成功人士所需的科学和专业技能 独立研究者并领导一项研究计划，推动与药物相关的 SCA 领域的发展 使用。