Clinical Research and Community Engagement Core

临床研究和社区参与核心

• 批准号: 10504810
• 负责人: JING CHEN
• 金额: $ 31.26万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-10 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10504810
• 关键词: Adoption; Biochemical; Bioinformatics; Biostatistics Core; Blood; Businesses; Cardiometabolic Disease; Centers of Research Excellence; Clinic; Clinical; Clinical Research; Collection; Communities; Data Collection; Development; Diagnosis; Dissemination and Implementation; Ensure; Etiology; Farm; Fees; Freezing; Funding; Future; Goals; Grant; Healthcare; Hurricane; Individual; Institutes; Institutional Review Boards; International; Intervention; Laboratories; Manuals; Multi-Institutional Clinical Trial; Nursing Research; Paper; Patient Recruitments; Peer Review; Phase; Pilot Projects; Play; Preparation; Prevention; Procedures; Protocols documentation; Publishing; Quality Control; Research; Research Infrastructure; Research Peer Review; Research Personnel; Research Project Grants; Research Support; Resources; Role; Sampling; Services; Specimen; Translational Research; Translations; United States National Institutes of Health; Universities; Urine; Visit; base; clinical infrastructure; community engagement; cost; equipment training; implementation research; improved; intervention delivery; operation; participant retention; population health; programs; protocol development; quality assurance; real world application; recruit; research facility; success; translational pipeline; translational research program

PROJECT SUMMARY/ABSTRACT (Clinical Research and Community Engagement Core) The Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases (Phase 1) has successfully supported Tulane University's efforts to increase the quality and quantity of clinical and translational research in cardiometabolic diseases. The Clinical Research Core played a central role in the success of COBRE Phase 1, which included seven Research Project Leaders (RPLs) and Pilot Project Leaders (PPLs) who received one or more research grants from NIH and NSF and 310 peer-reviewed scientific articles published by COBRE investigators. This COBRE Phase 2 application aims to further develop and strengthen the clinical and translational research infrastructure at Tulane University and to continuously expand and support a critical mass of investigators with expertise in clinical and translational research in cardiometabolic diseases. In Phase 2, the Clinical Research Core will be expanded into the Clinical Research and Community Engagement (CRCE) Core and the Bioinformatics and Biostatistics Core. The CRCE Core will continue to support RPLs, PPLs, other COBRE investigators, and collaborators through our research clinics and biochemical laboratories and will expand efforts to strengthen and broaden capacity for community engagement across the translational research spectrum. The overall objectives of the CRCE Core are two-fold: to enhance and expand an effective and robust infrastructure for clinical and translational research, including research clinics, clinical and biochemical laboratories, and community engagement at Tulane University, and to facilitate and support RPLs, PPLs, other COBRE investigators, and collaborators in the planning and conduct of clinical research. To achieve these objectives, the specific aims are: 1) provide clinical research facilities and staff for study protocol development, regulatory support, participant recruitment, intervention conduct, and data collection for RPLs, PPLs, other COBRE investigators, and collaborators to implement their individual research projects, 2) provide clinical and biochemical laboratory support for the collection, processing, analysis, and storage of study specimens, 3) increase capacity for community and stakeholder engagement across the spectrum of translational research in cardiometabolic diseases to enhance study recruitment, retention, and dissemination and translation of study findings, and 4) develop a plan to ensure the long-term sustainability of Core operations. The CRCE Core is critically important for the proposed COBRE Phase 2 program. All four proposed individual Research Projects will utilize the clinical research space and staff and biochemical laboratories. In addition, community engagement support is available to RPLs, PPLs, other COBRE investigators, and collaborators. The CRCE Core will play a central role in assisting RPLs and PPLs with their Research Projects and their transition into independent investigators. The Core will also play an important role in establishing and maintaining a nationally and internationally recognized clinical and translational research program in the etiology, prevention, diagnosis, and treatment of cardiometabolic diseases at Tulane University.

项目摘要/摘要（临床研究和社区参与核心） 杜兰大学 COBRE 心脏代谢疾病临床和转化研究（第一阶段） 成功支持杜兰大学提高临床和临床研究质量和数量的努力 心脏代谢疾病的转化研究。临床研究核心在其中发挥了核心作用 COBRE 第一阶段的成功，其中包括七个研究项目负责人 (RPL) 和试点项目 获得 NIH 和 NSF 一项或多项研究资助以及 310 项同行评审的领导者 (PPL) COBRE 研究人员发表的科学文章。 COBRE 第 2 阶段应用旨在进一步开发 加强杜兰大学的临床和转化研究基础设施，并不断 扩大并支持大量具有临床和转化研究专业知识的研究人员 心脏代谢疾病。在第二阶段，临床研究核心将扩展到临床研究 和社区参与（CRCE）核心以及生物信息学和生物统计学核心。 CRCE 核心将 继续通过我们的研究诊所支持 RPL、PPL、其他 COBRE 研究人员和合作者 和生化实验室，并将加大力度加强和扩大社区能力 跨转化研究领域的参与。 CRCE 核心的总体目标有两个： 加强和扩大临床和转化研究的有效和强大的基础设施，包括 杜兰大学的研究诊所、临床和生化实验室以及社区参与，以及 促进和支持 RPL、PPL、其他 COBRE 调查人员和合作者的规划和实施 的临床研究。为了实现这些目标，具体目标是：1）提供临床研究设施和 研究方案制定、监管支持、参与者招募、干预行为和数据的工作人员 供 RPL、PPL、其他 COBRE 研究人员和合作者实施其个人研究的集合 项目，2) 为收集、处理、分析和分析提供临床和生化实验室支持 研究样本的存储，3) 提高社区和利益相关者参与的能力 心脏代谢疾病领域的一系列转化研究，以增强研究招募、保留和 传播和翻译研究结果，以及 4) 制定计划以确保长期可持续性 核心业务。 CRCE 核心对于拟议的 COBRE 第 2 阶段计划至关重要。所有四个 拟议的个别研究项目将利用临床研究空间和人员以及生化 实验室。此外，RPL、PPL 和其他 COBRE 还可获得社区参与支持 研究者和合作者。 CRCE 核心将在协助 RPL 和 PPL 方面发挥核心作用 研究项目及其向独立研究者的转变。核心也将发挥重要作用 建立和维持国内和国际认可的临床和转化研究 杜兰大学心脏代谢疾病的病因学、预防、诊断和治疗项目。