Jackson Heart Study (JHS) Graduate Training and Education Center (GTEC) - Sheila Malone Diversity Supplement

杰克逊心脏研究 (JHS) 研究生培训和教育中心 (GTEC) - Sheila Malone 多样性补充资料

基本信息

批准号：
10499086
负责人：
MARINELLE PAYTON
金额：
$ 4.04万
依托单位：
JACKSON STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-30 至 2023-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10499086
关键词：
African American Age Ancillary Study Area Blood Pressure Blood coagulation Body Size Cardiovascular Diseases Cholesterol Clinic Clinical Communities Community Health Education Coronary artery County Data Data Analyses Diabetes Mellitus Discrimination Disease Electrocardiogram Event Family member Future Genetic Glucose Habits Health Promotion Height Hospitalization Hypertension Institutes Institution Interview Investigation Jackson Heart Study Knowledge Laboratories Life Style Lipids Manuscripts Mathematics Measurement Medical History Medical center Mentorship Minority Mississippi National Heart, Lung, and Blood Institute Neck Obesity Outpatients Participant Pharmaceutical Preparations Phase Physical assessment Physiological Population Prevalence Prevention Publications Questionnaires Research Research Personnel Resources Risk Factors Science Series Site Socioeconomic Status Students Testing Time Training Training and Education Ultrasonography United States National Institutes of Health Universities Validation Visit Weight Woman base career cohort college epidemiology study falls graduate student health disparity improved innovation interest men metropolitan minority health programs prospective pulmonary function recruit risk prediction social social culture undergraduate student

项目摘要

The Jackson Heart Study (JHS), the largest investigation of CVD undertaken in an African-American population, is a single-site prospective epidemiologic investigation in the Jackson, Mississippi metropolitan area of Hinds, Madison, and Rankin counties. The JHS is sponsored by the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Minority Health and Health Disparities (NIMHD) at the National Institutes of Health (NIH). The JHS started as a partnership between three local institutions: Jackson State University, Tougaloo College, and the University of Mississippi Medical Center and recruited 5,306 African-American men and women between the ages of 35 and 84. Family members were included in order to permit studies of familial and genetic contributions to CVD. The initial examination phase of the study lasted from the fall of 2000 to March 2004 and involved an extensive examination that included a series of questionnaires (dealing with lifestyle habits, medical history, medications, social and cultural factors), physical assessments (height, weight, body size, blood pressure, electrocardiogram, ultrasound measurements of the heart and arteries in the neck, and lung function) and laboratory measurements (cholesterol and other lipids, glucose, indicators related to clotting of the blood, among others). The information collected in this study includes both conventional risk factors and new or emerging factors that may be related to CVD. It also included newer areas of focus comprising early indicators of disease, genetics, socio-cultural influences, such as socioeconomic status and discrimination, and physiological relations between common disorders such as high blood pressure, obesity and diabetes and their influence on CVD. Exam 2 was conducted between 2005 and 2008, and Exam 3 from 2009 to 2012. The next phase of the JHS extended from 2013-2018 and did not include a clinic exam. The five major aims of the JHS are: (1) Support dedicated time for JHS investigators to conduct data analysis and prepare manuscripts using the wealth of collected JHS data; (2) Facilitate access to study resources and expertise in order to: (a) engage researchers beyond the JHS in collaborative analysis of existing data to produce high quality publications; (b) serve as a training ground for undergraduate and graduate students and early career investigators, as appropriate, to help ameliorate the shortage of minority biomedical researchers; and (c) serve as a platform for ancillary studies; (3) Conduct annual interviews with participants to identify interim hospitalizations and outpatient visits, convey information about the JHS, and serve as a vehicle to recruit for ancillary studies; (4) Continue clinical events identification, investigation, and validation to improve statistical power for risk prediction and hypothesis testing; (5) Perform community health education activities to disseminate health promotion and prevention messages in the Jackson community. The JHS Graduate Training and Education Center (GTEC) has four objectives that will serve to help the JHS achieve all of its aims in general and, in particular, Aim 2b listed above. The four objectives of the GTEC are to: (1) strengthen the base of participating students' knowledge of science and mathematics; (2) provide innovative programs, research opportunities, and mentorship to stimulate and nurture students' interest in science and research; (3) produce publications and informational articles on educational topics for broader audiences; and (4) encourage students to pursue further training for future biomedical careers.

杰克逊心脏研究 (JHS) 是在非裔美国人群体中进行的最大规模的 CVD 调查，是在密西西比州杰克逊都会区的海因兹县、麦迪逊县和兰金县进行的单点前瞻性流行病学调查。 JHS 由国家心肺血液研究所 (NHLBI) 和美国国立卫生研究院 (NIH) 下属的国家少数民族健康与健康差异研究所 (NIMHD) 赞助。 JHS 最初是三个当地机构（杰克逊州立大学、图加卢学院和密西西比大学医学中心）之间的合作伙伴关系，招募了 5,306 名年龄在 35 岁至 84 岁之间的非裔美国男性和女性。家庭成员也被包括在内，以便允许CVD 的家族和遗传贡献的研究。该研究的初始检查阶段从2000年秋天持续到2004年3月，涉及广泛的检查，包括一系列调查问卷（涉及生活习惯、病史、药物、社会和文化因素）、身体评估（身高、体重）、身体尺寸、血压、心电图、心脏和颈部动脉的超声测量以及肺功能）和实验室测量（胆固醇和其他脂质、葡萄糖、与血液凝固相关的指标等）其他的）。本研究收集的信息包括传统的危险因素和可能与 CVD 相关的新的或正在出现的因素。它还包括新的重点领域，包括疾病的早期指标、遗传学、社会文化影响（例如社会经济地位和歧视）以及高血压、肥胖和糖尿病等常见疾病之间的生理关系及其对心血管疾病的影响。第二次考试于 2005 年至 2008 年进行，第三次考试于 2009 年至 2012 年进行。JHS 的下一阶段从 2013 年至 2018 年进行，不包括临床考试。 JHS 的五个主要目标是： (1) 支持 JHS 研究人员投入专门时间进行数据分析，并利用收集到的丰富的 JHS 数据准备手稿； (2) 促进获取研究资源和专业知识，以便： (a) 让 JHS 以外的研究人员参与现有数据的协作分析，以产出高质量的出版物； (b) 酌情作为本科生和研究生以及早期职业研究人员的培训基地，以帮助改善少数族裔生物医学研究人员的短缺问题； (c) 作为辅助研究的平台； (3) 对参与者进行年度访谈，以确定临时住院和门诊就诊，传达有关 JHS 的信息，并作为辅助研究招募的工具； (4) 继续进行临床事件识别、调查和验证，以提高风险预测和假设检验的统计能力； (5) 开展社区健康教育活动，在杰克逊社区传播健康促进和预防信息。 JHS 研究生培训和教育中心 (GTEC) 有四个目标，将有助于帮助 JHS 实现其所有总体目标，特别是上面列出的目标 2b。 GTEC 的四个目标是： (1) 加强参与学生的科学和数学知识基础； (2) 提供创新项目、研究机会和指导，激发和培养学生对科学和研究的兴趣； (3) 为更广泛的受众制作有关教育主题的出版物和信息文章； (4) 鼓励学生为未来的生物医学职业接受进一步的培训。