LEARNED TOLERANCE TO ALCOHOL IN HUMANS

人类对酒精的耐受性

• 批准号: 2043786
• 负责人: ROBERT H BENNETT
• 金额: $ 10.49万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-01-01 至 1994-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2043786
• 关键词: alcoholic beverage consumption; behavior; diagnostic tests; dosage; human subject; performance

APPLICANT'S ABSTRACT: The proposed application is designed to employ a novel procedure to study the learning variables involved in the development of behavioral tolerance to alcohol in humans. The initial experiment examines the development of acute tolerance within a day and behavioral tolerance (developed over consecutive days of exposure) using three different doses of ethanol and two different tasks. One task will be a computer controlled video game and the other task will be a pursuit-rotor task. The primary objective is to assess the sensitivity of the tasks to tolerance development and to investigate the dose response relationship across subjects. A behavioral study will examine the independence of performance on the tasks within subjects. If performance on the tasks are observed to be independent (i.e. performance on one task does not influence the performance level on the other task) both tasks may be used in other studies proposed. The remaining experiments will use the alcohol before - alcohol after task performance technique to control for the effects of alcohol exposure alone in contrast to task practice while intoxicated with alcohol. The role of performance feedback in tolerance development will be investigated in experiment 3 and transfer of tolerance and the effects of task difficulty will be examined in experiment 4. The results of the proposed studies could serve as behavioral baselines for future research into the role genetic risk factors and family history and their relation to behavioral tolerance. In addition, the procedure can serve to investigate the role of environmental cues, social learning variables and other variables of clinical relevance related to tolerance development in humans.

申请人摘要：所提议的应用程序旨在采用 研究开发中涉及的学习变量的新颖程序 人类对酒精的行为耐受性。 初步实验 检查一天内急性耐受性的发展和行为 耐受性（在连续几天的暴露中形成）使用三个 不同剂量的乙醇和两项不同的任务。 一项任务将是 计算机控制的视频游戏，另一个任务是追逐转子 任务。 主要目标是评估任务的敏感性 耐受性发展并研究剂量反应关系 跨学科。 行为研究将检验 科目内任务的表现。 如果任务的表现是 观察到是独立的（即一项任务的表现不会影响 其他任务的性能水平）这两个任务可以在其他任务中使用 提出的研究。 剩下的实验将使用之前的酒精—— 任务执行后酒精控制的影响 与醉酒时的任务实践相比，单独暴露于酒精 酒精。 绩效反馈在耐受性发展中的作用将是 在实验3中研究了耐受性的转移和影响 任务难度将在实验 4 中进行检验。 拟议的研究可以作为未来研究的行为基线 遗传风险因素和家族史的作用及其与 行为宽容。 此外，该程序还可用于调查 环境线索、社会学习变量和其他因素的作用 与人类耐受性发展相关的临床相关变量。