CLINICALLY RELEVANT MARKERS OF ALCOHOLIC SUBGROUPS

酒精亚组的临床相关标志物

• 批准号: 2045991
• 负责人: ROBERT M ANTHENELLI
• 金额: $ 8.36万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-01 至 1998-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2045991
• 关键词: alcoholism /alcohol abuse; antisocial personality; biomarker; disease /disorder classification; disease /disorder proneness /risk; enzyme activity; fenfluramine; human subject; impulsive behavior; prolactin; psychological tests; serotonin

Better identification of subgroups of alcoholics with comorbid antisocial personality disorder (ASPD) has important implications for men and women seeking treatment. The proposed work requests 5 years funding to increase our understanding of the mechanisms that might possibly underlie elements of both ASPD and the risk for developing alcoholism. The research focuses on how serotonergic (5-HT) function, as measured by prolactin responses to a 5-HT releasing agent, fenfluramine, might be used as a biological marker to identify subgroups of alcoholics. the study will also explore the relationship between 5-HT function, platelet monoamine oxidase (MAO) activity levels, and psychometric measures of impulsivity. The hypotheses to be tested explore whether ASPD and alcoholism are separate disorders with some overlapping behaviors or if they are related to one another along a continuum. In addition, we predict that platelet MAO activity levels and the prolactin response to the fenfluramine challenge will be positively associated. Thus, both of these biological markers will be inversely correlated to measures of impulsive aggression. Ss will be a consecutive series of 18-55 year old ASPD and/or alcohol- dependent men and women admitted to inpatient services at 2 UCSD- affiliated hospitals. Our 4 groups will include: 30 ASP-alcoholics; 30 non-ASP alcoholics; 30 ASP non-alcoholics; and 30 NC. Structured interviews, standardized psychometric measures of impulsive aggression, resource person interviews, and all available public information will be obtained to establish careful diagnoses in these individuals. The study will use a double blind, randomized, fenfluramine (100 mg. p.o.) versus placebo control design. Ss will return to the hospital for the 2 separate challenge sessions within 7-14 days of discharge (a minimum of 5-7 weeks of total abstinence). Hormonal (prolactin, ACTH, cortisol) responses, heart rate, blood pressure, and body temperature changes over time will be determined at 30 min. intervals throughout the test sessions. Platelet MAO activity levels will also be obtained. This work should contribute significantly to our understanding of the mechanisms linking ASPD, alcohol dependence, nd impulsive aggressive personality traits, and should help better identify subgroups of alcoholics with different treatment needs.

更好地识别合并症的酗酒者亚组 人格障碍（ASPD）对男人和女人具有重要意义 寻求治疗。 拟议的工作要求提供5年的资金 提高我们对可能基础机制的理解 ASPD的要素和酗酒的风险。 该研究的重点是如何通过 催乳素对5-HT释放剂Fenfluramine的反应可能是 用作鉴定酗酒者亚组的生物标记。 这 研究还将探索5-HT功能，血小板之间的关系 单胺氧化酶（MAO）活性水平和心理测量指标 冲动。 要测试的假设探讨了ASPD和酒精中毒是否是 具有一些重叠行为或相关的单独疾病 沿着连续体彼此。 此外，我们预测该血小板 MAO活性水平和对芬氟拉明的催乳素反应 挑战将是积极关联的。 因此，这两个生物学 标记将与冲动攻击的措施成反比。 SS将是一系列18-55岁的ASPD和/或酒精 - 受抚养男女在2 UCSD-的住院服务中承认 附属医院。 我们的4组将包括：30个ASP醇含量； 30 非亚士酗酒者； 30 ASP非酒精饮料；和30 NC。 结构 访谈，冲动侵略的标准化心理测量指标， 资源人员的访谈，所有可用的公共信息将是 获得的是在这些人中仔细诊断。 该研究将使用双盲，随机的芬氟拉明（100 mg。 P.O.）与安慰剂控制设计。 SS将返回医院 出院7-14天内的2个单独的挑战会议（a 至少5-7周的总节制）。 激素（催乳素，ACTH，，， 皮质醇）反应，心率，血压和体温 随着时间的变化将在30分钟确定。整个间隔 测试会议。 还将获得血小板MAO活性水平。 这 工作应为我们对我们的理解做出重大贡献 连接ASPD，酒精依赖性，脉冲侵略性的机制 个性特征，应有助于更好地识别 有不同治疗需求的酗酒者。