Michigan Interdisciplinary Center for Urology Research and Education (MI-CURE)

密歇根泌尿外科研究和教育跨学科中心 (MI-CURE)

• 批准号: 10491200
• 负责人: MICHAEL B CHANCELLOR
• 金额: $ 29.41万
• 依托单位: WILLIAM BEAUMONT HOSPITAL RESEARCH INST
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-22 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10491200
• 关键词: Address; Adult; Applications Grants; Area; Benign; Biological; Biomechanics; Bladder; Bladder Dysfunction; Cellular biology; Clinical; Collaborations; Communication; Development; Discipline; Disease; Education; Engineering; Ensure; Environment; Esthesia; Event; Fibrosis; Fostering; Foundations; Functional disorder; Funding; Future; Genitourinary system; Goals; Health system; High School Student; Hospitals; Image; Infrastructure; Interdisciplinary Study; Investigation; Joints; K-Series Research Career Programs; Knowledge; Mechanics; Medical Students; Mentors; Methodology; Michigan; Movement; Muscle; Muscle Tonus; Physicians; Physiology; Positioning Attribute; Prevention strategy; Program Development; Property; Research; Research Personnel; Resources; Role; Scientist; Sensory; Site; Stress; Stretching; Sum; System; Talents; Testing; Training; United States National Institutes of Health; Universities; Urogenital Diseases; Urologist; Urology; Work; afferent nerve; base; career; career development; conflict resolution; design; high school; imaging system; innovation; insight; interdisciplinary collaboration; interest; mathematical model; medical schools; meetings; novel; novel therapeutics; pressure; programs; recruit; sex; soft tissue; statistics; success; symposium; synergism; training opportunity; treatment strategy; urologic

ABSTRACT The Michigan Interdisciplinary Center for Urology Research and Education (MI-CURE) seeks to develop a world-class interdisciplinary research team comprised of scientists, clinicians, biostatisticians, and engineers to provide comprehensive and innovative approaches in benign urology. As such, we have brought together exceptional investigators with diverse expertise from Beaumont Hospital/ Oakland University William Beaumont School of Medicine and Michigan State University. The overall purpose of the MI-CURE Exploratory Center is to establish strong research foundations in bladder physiology, develop an intellectual infrastructure, and expand educational and training opportunities in benign urology research. Despite decades of research, the mechanisms by which bladder fullness is sensed are still unknown. A major barrier to developing and testing novel therapies for bladder dysfunction is our lack of understanding the mechanism of how bladder fullness is sensed. Thus, the overall goal of this initial project is to understand the basis of pressure sensing and its linkage to afferent nerve activation during bladder filling, and consequently how bladder remodeling and altered bladder wall compliance during disease can impact these mechanisms. To address this significant knowledge gap, we have assembled an interdisciplinary team of experts in physiology, cell biology, fibrosis, neurourology, statistics, and clinical urology and have recruited a promising new investigator in engineering to benign genitourinary disease, Dr. Sara Roccabianca. She has unique expertise in soft tissue mechanical characterization, microstructural quantification, and mathematical modeling of soft tissues movement. In addition to the strong benign urology research program using innovative and cutting-edge approaches, MI-CURE has an exciting Educational Enrichment Program to train and mentor all levels of adult learners, from high school students to medical students, to help expand and enhance benign urology research. MI-CURE is co-directed by the established physician-scientist team of Drs. Laura Lamb and Michael Chancellor, with clear communication and coordination plans in place. Together, MI-CURE will foster successful collaborations, education initiatives, and innovative research. Funding of MI-CURE as a P20 Exploratory Center will allow us to work with the George M. O'Brien Urology Cooperative Research Centers Program and the KURe and UroEpi career development programs through joint meetings and conference calls. Our goal is to leverage our collective resources and results into well-designed, novel projects suitable for submission as future NIH Investigator-Initiated R01s. We believe that the Michigan Interdisciplinary Center for Urology Research and Education program as a whole will be greater than the sum of its parts and will contribute to developing talented researchers in benign genitourinary disorders.

抽象的 密歇根泌尿学研究和教育跨学科中心 (MI-CURE) 寻求 建立一支由科学家、临床医生、生物统计学家组成的世界一流的跨学科研究团队， 和工程师提供良性泌尿外科全面和创新的方法。因此，我们有 汇集了来自奥克兰博蒙特医院的具有不同专业知识的杰出研究人员 大学威廉博蒙特医学院和密歇根州立大学。 MI-CURE 探索中心的总体目标是建立强大的研究基础 在膀胱生理学方面，开发智力基础设施，并扩大教育和培训 良性泌尿外科研究的机会。尽管经过了数十年的研究，膀胱的机制 是否感觉到饱满度仍然未知。开发和测试膀胱新疗法的主要障碍 功能障碍是我们缺乏对膀胱充盈感的机制的了解。因此，总体 这个初始项目的目标是了解压力传感的基础及其与传入神经的联系 膀胱充盈过程中的激活，以及膀胱如何重塑和改变膀胱壁 疾病期间的依从性会影响这些机制。为了解决这一重大知识差距，我们 组建了一支由生理学、细胞生物学、纤维化、神经泌尿学专家组成的跨学科团队， 统计学和临床​​泌尿学，并招募了一位有前途的良性工程新研究人员 泌尿生殖系统疾病，Sara Roccabianca 博士。她在软组织机械方面拥有独特的专业知识 软组织运动的表征、微观结构量化和数学建模。 除了使用创新和尖端技术的强大良性泌尿学研究计划 方法，MI-CURE 有一个令人兴奋的教育强化计划来培训和指导各个级别的 成人学习者，从高中生到医学生，帮助扩大和加强良性泌尿外科 研究。 MI-CURE 由已建立的医师科学家团队共同领导。劳拉·兰姆和 迈克尔·财政大臣，制定了明确的沟通和协调计划。 MI-CURE 将共同努力 促进成功的合作、教育举措和创新研究。 MI-CURE 作为 P20 探索中心的资助将使我们能够与 George M. O'Brien 合作 泌尿科合作研究中心计划以及 KURe 和 UroEpi 职业发展计划 通过联席会议和电话会议。我们的目标是利用我们的集体资源和成果 适合作为未来 NIH 研究者发起的 R01 提交的精心设计的新颖项目。我们 相信密歇根泌尿外科跨学科研究和教育项目作为一个整体 将大于其各部分的总和，并将有助于培养良性研究人员 泌尿生殖系统疾病。

项目成果

Increased extracellular matrix stiffness accompanies compromised bladder function in a murine model of radiation cystitis.

在放射性膀胱炎小鼠模型中，细胞外基质硬度增加伴随着膀胱功能受损。

• 发表时间: 2022-05
• 影响因子: 9.7
• 作者: Zwaans, Bernadette M M;Grobbel, Marissa;Carabulea, Alexander L;Lamb, Laura E;Roccabianca, Sara
• 通讯作者: Roccabianca, Sara