NORMAL AND PATHOLOGICAL BRAIN IRON

正常和病理性脑铁

• 批准号: 2270308
• 负责人: ARNULF HANS-WERNER KOEPPEN
• 金额: $ 0.84万
• 依托单位: ALBANY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-01 至 1995-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2270308
• 关键词: brain metabolism; iron metabolism; meeting /conference /symposium; travel

In recent years, normal and pathological brain iron have attracted renewed interest because of concern that some common disorders such as Parkinson's disease and Alzheimer's dementia are associated with changes in local iron metabolism. Magnetic resonance imaging now permits the visualization of normal brain iron in the substantia nigra, the red nuclei, the dentate nuclei, and the globus pallidus, and the stepwise conversion of extravasated hemoglobin iron to hemosiderin. The cellular events accompanying this conversion have been clarified by the immunocytochemical and ultrastructural visualization of ferritin in microglia, and of the ferritin repressor protein in astrocytes. In addition to ferritin, other iron-carrying proteins have been found in brain. Among these proteins, transferrin has become prominent as an immunocytochemical marker of oligodendroglia and as an indicator of oligodendroglial maturation during myelination. The severity of stroke and trauma may depend in part on iron-catalyzed lipid peroxidation, and the accelerated biosynthesis of heavy ferritin is thought to be an important defense mechanism against tissue injury. Despite the recent advances in the knowledge of distribution and cellular localization, brain iron continues to be quite enigmatic. The proposed satellite symposium seeks to bring together selected experts in the field of normal and pathological brain iron and will include students of iron imaging and iron-catalyzed lipid peroxidation. The conference will also resolve questions about the role of transferrin and the transferrin receptor in the transport of mobile iron across the blood brain barrier, the importance of microglia in the resolution of hemorrhagic brain lesions, and the behavior of brain iron during growth and systemic iron deficiency.

近年来，正常和病理脑铁吸引了 由于担心某些常见疾病，例如 帕金森氏病和阿尔茨海默氏症的痴呆与变化有关 在局部铁代谢中。磁共振成像现在允许 黑质中正常脑铁的可视化，红色 核，齿状核和果皮球核，以及逐步 将血红蛋白铁递送为血红蛋白的转化。细胞 伴随此转换的事件已被阐明 铁蛋白的免疫细胞化学和超微结构可视化 小胶质细胞和星形胶质细胞中的铁蛋白抑制剂蛋白。在 除铁蛋白外，还发现了其他携带铁的蛋白 脑。在这些蛋白质中，转铁蛋白已成为一个突出的 少突齿的免疫细胞化学标志物，作为指标 髓鞘化过程中的少突胶质成熟。中风的严重程度 创伤可能部分取决于铁催化的脂质过氧化和 重铁蛋白的加速生物合成被认为是一种 针对组织损伤的重要防御机制。尽管最近有 分布和细胞定位的知识的进步， 脑铁继续是奇怪的。提议的卫星 研讨会旨在将正常领域的选定专家汇集在一起 和病理脑铁，将包括铁成像的学生和 铁催化的脂质过氧化。会议也将解决 关于转铁蛋白和转铁蛋白受体在中的作用的问题 移动铁在血脑屏障上的运输， 小胶质细胞在分辨出出血性脑病变中的重要性， 以及在生长和全身铁期间脑铁的行为 不足。