MUSCLE ENRICHED TRANSCRIPTION FACTOR

肌肉富集转录因子

• 批准号: 2292988
• 负责人: SARAH B LARKIN
• 金额: $ 3.12万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-05-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2292988
• 关键词: MUSCLE; ENRICHED; TRANSCRIPTION; FACTOR

The overall goal of the projects outlined below is to characterize the functional requirement of the muscle-enriched transcription factor, M-CAT binding factor (MCBF) for auxiliary proteins, other DNA-bound transcription factors and transcriptional intermediary factors, and particularly to investigate the basis of its differing requirements in cardiac and skeletal myocytes. 1. To investigate the requirement of MCBF for transcriptional intermediary factors. 2. To examine the means by which MCBF interacts with other promoter- bound transcription factors to produce a synergistic activation of transcription. 3. To determine the basis for the additional requirement for distal promoter sequences (the 'cardiac element"), and associated transcription factor(s), for activation of the cTNT promoter in myocardial cells versus embryonic skeletal muscle cell.

以下概述的项目的总体目标是表征 富含肌肉的转录因子M-CAT的功能需求 辅助蛋白的结合因子（MCBF），其他DNA结合 转录因子和转录中间因素，以及 特别是调查其不同要求的基础 心脏和骨骼心肌细胞。 1。研究MCBF对转录的要求 中间因素。 2。检查MCBF与其他启动子相互作用的手段 - 结合转录因子产生协同激活 转录。 3。确定远端的额外要求的基础 启动子序列（“心脏元素”）和相关的转录 因子，用于激活心肌细胞中CTNT启动子 胚胎骨骼肌细胞。