Social support to retain adolescents living with HIV in care and improve ART adherence

社会支持以保留艾滋病毒感染青少年并提高抗逆转录病毒疗法的依从性

基本信息

批准号：
10478844
负责人：
Tiarney D Ritchwood
金额：
$ 17.56万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-16 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10478844
关键词：
AIDS/HIV problem Adherence Adolescent Adult Africa South of the Sahara Applications Grants Appointment Award Behavioral CD4 Lymphocyte Count Caring Characteristics Child Clinic Collaborations Communities Computers Country Data Development Disease Management Emotional Evaluation Focus Groups Food Frequencies Future Goals Grant HIV Health Personnel Healthcare Incidence Individual Information Networks Interruption Intervention Interview K-Series Research Career Programs Knowledge Link Malignant Neoplasms Measures Mentors Mentorship Methods Monitor Morbidity - disease rate Network-based Outcome Pathway Analysis Patient Self-Report Patients Persons Pharmaceutical Preparations Pilot Projects Population Provider Public Health Public Health Schools Records Regimen Reporting Research Personnel Research Project Grants Resistance Resources Role Safety Sampling Studies Science Scientist Secure Services Shelter facility Social Network Social support Societies South Africa South African Specificity Stigmatization Structure Target Populations Testing Training United States National Institutes of Health Universities Viral Viral Load result Virus Work acceptability and feasibility age group antiretroviral therapy base behavioral health career career development design digital efficacious intervention experience follow-up global health improved improved outcome innovation member mortality multidisciplinary pandemic disease premature psychologic scale up skills social structure theories therapy design therapy development transmission process treatment adherence

项目摘要

ABSTRACT Career Goal: I am committed to a career as a behavioral health scientist, integrating psychological science with public health. My goal is to develop interventions that improve outcomes among adolescents living with HIV (ALWH) globally. Career Development: This career development award will enhance my analytical skills and provide specific training in social network analysis, and intervention development, testing, and evaluation. In this application, I seek to: 1) gain proficiency in the use of social network analysis to inform intervention development; 2) gain essential skills to develop an interactive, network-based, social support intervention to retain ALWH in HIV care and improve ART adherence; 3) obtain the training needed to use preliminary data gathered from this proposal to support a follow up grant proposal for a larger trial aimed at evaluating the proposed intervention. Research Project: Compared to other age groups, South African ALWH are least adherent to medication regimens, resulting in elevated rates of HIV-related morbidity, mortality, medication resistance, and HIV transmission. To improve the outcomes of ALWH, we must identify innovative and engaging methods to retain them in HIV care. The overall goal of the proposed study is to advance knowledge on the role of ALWHs’ social networks in their treatment-related outcomes and develop a network-based, social support intervention to retain them in HIV care and increase ART adherence. First, I will conduct an egocentric social network analysis of ALWH to determine how key members of their social networks influence their retention in HIV care and ART adherence. Next, I will conduct qualitative analysis using data from ALWH and their network members to identify best practices to facilitate intervention acceptability and feasibility. Then, I will use participatory methods to adapt two network-based interventions to fit the target population and increase their retention in HIV care and ART adherence. Lastly, I will conduct a pilot study in Cape Town, South Africa to evaluate the intervention. Mentorship: I will work with a highly accomplished, multidisciplinary team of experts who will support me over the course of the proposed project. My mentors are Drs. John Bartlett (Duke University), Michael Sweat (MUSC Center for Global Health), Linda-Gail Bekker (Desmond Tutu HIV Centre, University of Cape Town), Michael Relf (Duke University), and Carl Latkin (Johns Hopkins Bloomberg School of Public Health) and my advisors are Drs. Audrey Pettifor (UNC) and Joseph Tucker (UNC). Future Directions. This award will also inform future NIH grant applications (R34 and R01) to optimize and evaluate the intervention in a larger study sample.

抽象的职业目标：我致力于成为一名行为健康科学家，整合心理科学我的目标是制定干预措施，改善青少年的生活状况。全球艾滋病毒 (ALWH) 职业发展：该职业发展奖将提高我的分析能力。并提供社交网络分析、干预措施开发、测试和评估方面的具体培训。在此应用程序中，我寻求：1）熟练使用社交网络分析来为干预提供信息 2) 获得开发交互式、基于网络的社会支持干预的基本技能保留 ALWH 参与 HIV 护理并提高 ART 依从性；3) 获得使用初步数据所需的培训；从该提案中收集的信息是为了支持一项旨在评估拟议的干预措施：与其他年龄组相比，南非 ALWH 的干预程度最低。坚持药物治疗方案，导致艾滋病毒相关发病率、死亡率、药物治疗率升高为了改善 ALWH 的结果，我们必须确定创新和有效的方法。拟议研究的总体目标是提高知识水平。 ALWH 的社交网络在其治疗相关结果中的作用，并开发一个基于网络的、社会支持干预，以保留他们接受艾滋病毒护理并提高抗逆转录病毒治疗的依从性。首先，我将进行一项调查。对 ALWH 进行以自我为中心的社交网络分析，以确定其社交网络的关键成员如何影响接下来，我将使用 ALWH 的数据进行定性分析。及其网络成员确定最佳实践，以促进干预的可接受性和可行性。我将使用参与式方法来调整两种基于网络的干预措施以适应目标人群和最后，我将在开普敦进行一项试点研究。南非评估干预：我将与一位卓有成就的多学科人士合作。我的导师是约翰博士，他们将在整个项目过程中为我提供支持。 Bartlett（杜克大学）、Michael Sweat（MUSC 全球健康中心）、Linda-Gail Bekker（德斯蒙德·图图）开普敦大学 HIV 中心）、Michael Relf（杜克大学）和 Carl Latkin（约翰·霍普金斯大学）布隆伯格公共卫生学院）和我的顾问是奥黛丽·佩蒂福博士（北卡罗来纳大学）和约瑟夫·塔克博士（北卡罗来纳大学）未来方向。该奖项还将为未来的 NIH 拨款申请（R34 和 R01）提供信息以进行优化。并在更大的研究样本中评估干预措施。