Project 3: Isolating food insecurity to understand childhood health outcomes and biological mechanisms of risk

项目 3：隔离粮食不安全以了解儿童健康结果和风险的生物机制

基本信息

批准号：
10478822
负责人：
E. Whitney Evans
金额：
$ 25.24万
依托单位：
MIRIAM HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-15 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10478822
关键词：
Address Adherence Adipose tissue Adult Affect Age American Anemia Animal Model Anxiety Behavior Biological Biological Markers Blood specimen Body mass index C-reactive protein Calories Caregivers Centers of Research Excellence Child Child Health Childhood Chronic Disease Collection Communities Consumption Diet Disadvantaged Exposure to Fasting Fatty acid glycerol esters Food Food Services Foundations Glucose Glycosylated hemoglobin A Health Healthy Eating Hour Household Hydrocortisone Impairment Impulsivity Inflammation Inflammatory Insulin Insulin Resistance Interleukin-6 Intervention Leptin Lipids Low income Malnutrition Measures Mediating Mental Depression Mental Health Metabolic syndrome Minority Moods Nature Newsletter Nutrient Outcome Overweight Participant Poverty Prevention Price Problem behavior Prospective Studies Proteins Randomized Research Resources Rhode Island Risk Role Schools Secure Ships Stress Testing Time Training Trauma Unhealthy Diet United States United States Department of Agriculture Weight Gain Woman Work Youth adipokines adiponectin adverse childhood events age group anxiety symptoms base blood glucose regulation career caregiver stress childhood adversity cytokine depressive symptoms dietary disorder risk excessive weight gain experience food insecurity glucose metabolism health disparity indexing maternal depression novel nutrition obesity in children obesity-associated asthma physical conditioning prevent primary endpoint programs prospective recruit resilience service programs social health determinants stress symptom sugar

项目摘要

PROJECT SUMMARY/ABSTRACT Food insecurity affects one in seven households with children in the United States and disproportionately impacts those headed by women and minorities. Food insecurity is associated with childhood obesity, asthma, anxiety and depression and behavioral problems, and thus contributes to health disparities. While food insecurity likely contributes to poor health through its effect on diet, such a simplistic understanding likely obscures the effects of stress – those unique to childhood, such as Adverse Childhood Experiences including maternal depression, as well as those generally associated with the experience of poverty. To inform the mechanisms by which food insecurity ultimately affects physical and mental health outcomes in children, this study will disentangle the effects of food insecurity from those of poverty and examine effects on diet, biomarkers, weight gain, mood and behavior while considering other childhood adversities. Specifically, through a unique summertime meal provision intervention, the proposed project will isolate the experience of food insecurity in children, ages 8-12 years, from low-income households in Providence, RI. In partnership with the YMCA of Greater Providence and the Healthy Communities Office in Providence, we will recruit 100 children over two summers. After completing a baseline assessment, participants will be randomized to the Food Insecure or Food Secure groups. Children randomized to the Food Insecure group will experience the natural onset of summertime food insecurity and receive a weekly newsletter on community resources that is not expected to affect food insecurity. Those randomized to the Food Secure group will remain food secure over the summer through receipt of weekly shipments of five breakfast and lunch meals that meet the nutrition needs of this age group. Primary endpoints include diet quality, biomarkers of Metabolic Syndrome, inflammation, and stress, BMI z-scores, and child measures of behavior and anxiety and depression symptoms. We will also explore the impact of caregiver mood and stress on the health effects of food insecurity. Ultimately, findings from this research will clarify the mechanisms by which food insecurity affects child health outcomes and inform how to more effectively prevent food insecurity. They will also provide the foundation for an R01 application and further training for Dr. Evans (PI) to establish an independent research career focused on understanding the role of diet in the prevention of health disparities in disadvantaged youth.

项目概要/摘要在美国，七分之一有孩子的家庭受到粮食不安全的影响，而且比例不成比例粮食不安全与儿童肥胖、哮喘、焦虑、抑郁和行为问题，从而导致健康差异。不安全感可能会通过影响饮食而导致健康状况不佳，这种简单化的理解可能会导致健康状况不佳掩盖了压力的影响——那些童年特有的影响，例如不良的童年经历，包括孕产妇抑郁症，以及那些通常与贫困经历相关的信息。粮食不安全最终影响儿童身心健康结果的机制，研究将区分粮食不安全的影响和贫困的影响，并研究对饮食的影响，生物标志物、体重增加、情绪和行为，同时考虑其他童年逆境。通过独特的夏季膳食供应干预，拟议的项目将隔离与罗德岛州普罗维登斯的低收入家庭 8 至 12 岁儿童的粮食不安全问题。大普罗维登斯基督教青年会和普罗维登斯健康社区办公室，我们将招募 100 名完成基线评估后，参与者将被随机分配到两个夏天的孩子。食品不安全或食品安全组随机分配到食品不安全组的儿童将经历以下情况：夏季粮食不安全的自然发生，并收到有关社区资源的每周通讯预计不会影响粮食不安全。随机分配到粮食安全组的人将保持粮食安全。整个夏季，每周收到五份符合营养要求的早餐和午餐该年龄组的需求包括饮食质量、代谢综合征的生物标志物、炎症、压力、BMI z 分数以及儿童行为、焦虑和抑郁的测量我们还将探讨看护者情绪和压力对食物健康的影响。最终，这项研究的结果将阐明粮食不安全的影响机制。儿童健康成果并告知如何更有效地预防粮食不安全。为 R01 申请奠定基础，并为 Evans 博士（PI）进行进一步培训以建立独立研究职业重点是了解饮食在预防弱势青少年健康差异方面的作用。