AIDS and Cancer Specimen Resource (ACSR)

艾滋病和癌症样本资源 (ACSR)

基本信息

批准号：
10477357
负责人：
Jeffrey Michael Bethony
金额：
$ 483.07万
依托单位：
GEORGE WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-23 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10477357
关键词：
AIDS Malignancy Consortium AIDS related cancer AIDS/HIV problem Acquired Immunodeficiency Syndrome Adherence Adult Affect Africa South of the Sahara African American Area Arizona Basic Science Biological Biological Specimen Banks Caribbean region Cause of Death Cessation of life Clinical Clinical Data Clinical Research Clinical Trials Collaborations Collection Complex Consent Data Data Pooling Development Economic Burden Ensure Epidemic Equipment and supply inventories Evolution Fostering Freezing Funding Geographic Locations Goals Growth HIV Head Health Hepatitis B Virus Hepatitis C virus Hispanic Americans Hodgkin Disease Human Herpesvirus 4 Human Papillomavirus Incidence Individual Infection Informatics Institution International Investigation Kaposi Sarcoma Latin America Latin American Leadership Link Liquid substance Malignant Neoplasms Malignant neoplasm of anus Malignant neoplasm of cervix uteri Malignant neoplasm of lung Marketing Medical Economics Methodology Mission Morbidity - disease rate Network Infrastructure Non-Hodgkin&apos s Lymphoma Outcome Pathogenesis Pathologic Patients Persons Play Prevalence Process Public Health Reporting Research Research Personnel Research Support Resources Risk Risk Factors Role Sample Size Sampling Science Scientist Site Smoking Specimen Standardization Structure Technology Testing Time Tissue Sample Translational Research Tumor Tissue U-Series Cooperative Agreements United States United States National Institutes of Health Universities Viral Washington Work aging population antiretroviral therapy biobank biological specimen archives cancer epidemiology cancer risk cancer specimen resource cancer therapy cancer type co-infection epidemiologic data fitness immune function informatics infrastructure men mortality new technology novel older patient outreach programs sample collection skills success tumor microenvironment virtual virtual repository virus related cancer working group

项目摘要

Abstract The AIDS epidemic, initially recognized in the early 1980's, currently affects more than 35 million people worldwide. Infection with the human immunodeficiency virus (HIV) is associated with a wide range of long term health complications including the development of cancer, currently a major cause of death among persons living with HIV/AIDS. The early form of the AIDS and Cancer Specimen Resource (ACSR) was established in 1994 as a cooperative agreement with the NCI with a mission to provide high quality biospecimens to researchers, a mission still paramount for the current ACSR. Principle investigators (MPIs) from the two legacy sites (GWU and UCSF) oversee the function of the ACSR to ensure the adherence to NCI best practices in this multinational program. The ACSR is currently the custodian for specimen collections from more than 20,000 individuals and makes these biospecimens available to eligible researchers studying HIV and cancer through an established specimen application process. In the past five years, investigators from more than 50 institutions have received research material from the ACSR. In addition, the ACSR has provided the centralized biospecimen collection and distribution functions for the AIDS Malignancy Consortium (AMC), which represents the NCI-funded international network of more than 30 clinical institutions involved in testing novel cancer therapies in HIV-infected individuals. The ACSR is structured into regional biospecimen repositories (RBRs) located in distinct geographical regions that reflect the US and global HIV epidemic and are unified (virtually) by an informatics infrastructure managed by the Hub for Integrated Informatics and Research Support (HIIRS). The RBRs are distinct but complementary in their diverse functions, with collaborative interactions fostered through the Governing Committee and ACSR-wide Working Groups that accomplish activities related to Science and Technology, Marketing and Outreach, Informatics, and Quality Management. As the HIV epidemic has evolved the types of cancers and the technologies used to study them have also changed. The newly reconfigured ACSR will have two divisions, both focused on obtaining the most important well-annotated (demographic, clinical, pathological and outcomes data) biospecimens for research as defined by investigator inquiries and the ACSR's scientific advisory board. The two MPIs, respectively will head the national and international AMC support program and the scientific direction of the ACSR. Both MPIs will work within the structure of the ACSR to obtain and provide to researcher's specimens most important for research in the current epidemic. Specific Aims include: 1) Acquire, store, and equitably distribute tumor tissues and biological fluids from individuals with HIV-associated malignancies (AIDS-defining cancers and non-AIDS defining cancers) to meet the biospecimen needs of researchers in HIV-associated malignancies; and 2) Promote the success of AMC clinical trials through mutually beneficial collaborations.

抽象的艾滋病流行于 1980 年代初首次被发现，目前影响超过 3500 万人全世界。人类免疫缺陷病毒 (HIV) 感染与多种长期疾病有关健康并发症，包括癌症的发展，目前是活着的人死亡的一个主要原因患有艾滋病毒/艾滋病。艾滋病和癌症样本资源 (ACSR) 的早期形式成立于 1994 年，名称为与 NCI 达成合作协议，其使命是为研究人员提供高质量的生物样本，对于当前的 ACSR 来说，使命仍然至关重要。来自两个遗留站点（GWU 和 UCSF）的原理研究者 (MPI) 负责监督 ACSR 的功能，以确保该跨国计划遵守 NCI 最佳实践。目前托管人为ACSR 收集超过 20,000 个人的样本，并将这些生物样本提供给符合条件的人研究人员通过既定的样本应用流程研究艾滋病毒和癌症。在过去的五年里多年来，来自 50 多个机构的研究人员收到了来自 ACSR 的研究材料。此外， ACSR为艾滋病恶性肿瘤提供集中的生物样本采集和分发功能联盟 (AMC)，代表 NCI 资助的由 30 多家临床机构组成的国际网络参与在艾滋病毒感染者中测试新型癌症疗法。 ACSR 的结构分为区域生物样本库 (RBR) 位于不同的地理区域，反映了美国和全球的艾滋病毒情况流行病，并由综合中心管理的信息学基础设施（实际上）统一信息学和研究支持（HIIRS）。 RBR 各不相同，但其不同的功能是互补的，通过理事会和 ACSR 范围内的工作组促进协作互动，完成与科学技术、营销和外展、信息学和质量相关的活动管理。随着艾滋病毒流行的发展，癌症的类型和用于研究癌症的技术也发生了变化。改变了。新重组的钢绞线将有两个部门，两个部门都专注于获得最重要的信息注释明确的（人口统计、临床、病理和结果数据）生物样本，用于定义的研究通过调查员调查和 ACSR 的科学顾问委员会。两个 MPI 将分别领导国家和国际 AMC 支持计划以及 ACSR 的科学方向。两个 MPI 都可以工作在 ACSR 的结构内，获取并向研究人员提供对研究最重要的样本当前的疫情。具体目标包括：1) 获取、储存和公平分配肿瘤组织和来自患有艾滋病毒相关恶性肿瘤（艾滋病定义的癌症和非艾滋病）的个体的生物体液定义癌症）以满足艾滋病毒相关恶性肿瘤研究人员的生物样本需求；和 2) 通过互利合作促进AMC临床试验的成功。