Penn Skin Biology and Diseases Resource-based Center

宾夕法尼亚大学皮肤生物学和疾病资源中心

• 批准号: 10477227
• 负责人: Elizabeth Anne Grice
• 金额: $ 81.25万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10477227
• 关键词: Academy; Advisory Committees; Bioinformatics; Biology; Biomedical Research; Blood specimen; Budgets; Cells; Clinic; Clinical; Collaborations; Communities; Community Outreach; Cutaneous; Data Science; Dermatologist; Dermatology; Diagnosis; Discipline; Disease; Disease model; Educational workshop; Ensure; Environment; Evaluation; Experimental Designs; Faculty; Financial Support; Fostering; Funding; Funding Mechanisms; Funding Opportunities; Future; Genomics; Goals; Health; High School Student; Histologic; Human; Informatics; Infrastructure; Innovative Therapy; Interdisciplinary Study; Investigation; Laboratories; Learning; Logistics; Medicine; Mentors; Mentorship; Minority Women; Molecular; Monitor; Patients; Pennsylvania; Phenotype; Philadelphia; Positioning Attribute; Prevention; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Schools; Seeds; Series; Services; Skin; Structure; Surveys; Techniques; Technology; Testing; Tissues; Training; Translating; Translational Research; Translations; Underrepresented Minority; Woman; base; career; design; diversity and inclusion; effectiveness evaluation; experimental study; imaging approach; improved; innovation; intravital imaging; lectures; member; multidisciplinary; new technology; next generation; operation; personalized approach; phenomics; programs; research study; skin disorder; success; summer internship; symposium; tissue resource; transcriptomics; volunteer

PROJECT SUMMARY The Penn Skin Biology and Diseases Resource-based Center (Penn SBDRC) will continue to support and accelerate skin disease research and its translation by providing critical infrastructure, resources, and expertise to skin investigators. The overall goals of the Penn SBDRC are to promote collaboration among skin investigators, especially across disciplines; to draw new investigators with diverse perspectives to skin research; to foster an environment that supports and cultivates the next generation of skin researchers; to increase access to technology and resources for conducting rigorous, impactful skin research; and to accelerate translation of research findings into innovative therapies for skin disease. To accomplish these goals, the aims of the Center are: Aim 1) To provide cutting-edge approaches and related expertise centered around 3 multi-disciplinary Resource Cores: Cutaneous Phenomics and Transcriptomics (CPAT) Core, Skin Translational Research (STaR) Core, and Data Science and Informatics (DSI) Core. These Cores are highly synergistic, providing high-demand and/or specialized services, valuable tissue/cellular resources, and the expertise to ensure rigorous experimental design, analytical strategies, and accurate interpretations. All Cores take advantage of the deep expertise of the Directors and Co-Directors and their research groups, to continuously improve and innovate upon techniques/approaches offered by the Center. Aim 2) To establish an Administrative Core that unifies skin investigators and promotes the goals of the SBDRC. The Administrative Core provides oversight and implements the activities of the center. This includes an Enrichment Program that is subdivided into 4 Sub-Cores: The Community Outreach Sub-Core introduces underserved Philadelphia public high school students to the excitement of biomedical research and dermatology through the Penn Academy of Skin Health (PASH), a Saturday academy and summer internship program. These programs also provide volunteer and mentorship opportunities for SBDRC members; The Mentoring Sub-Core promotes career success and training through structured mentorship for trainees and junior faculty. Through a partnership with the Dermatology Department’s Committee on Diversity and Inclusion, specialized mentoring programs for women and minorities underrepresented in medicine will be provided, as well as training for SBDRC mentors. The Scientific Enrichment Sub-Core sponsors a seminar series, workshops, and a yearly scientific symposium to promote interactions, collaboration, and innovative approaches among skin researchers. The Seed Funding Sub-Core offers 3 different funding mechanisms that attract new investigators and support the independence of junior investigators. The Penn SBDRC leverages the excellence of Penn Dermatology’s research and clinical programs as well as that of the entire Penn community to enhance collaboration, bringing new technology to skin research, and providing access to critical intellectual and technical resources that greatly enhance innovation and rigor in the study of skin disease. The Center impacts skin research well beyond Pennsylvania’s borders, and ultimately advances the treatment, prevention, and diagnosis of skin diseases.

项目概要 宾夕法尼亚州皮肤生物学和疾病资源中心 (Penn SBDRC) 将继续支持和 通过提供关键的基础设施、资源和专业知识来加速皮肤病研究及其转化 宾夕法尼亚大学 SBDRC 的总体目标是促进皮肤研究人员之间的合作。 研究人员，特别是跨学科的研究人员，以吸引具有不同观点的新研究人员； 研究；营造支持和培养下一代皮肤研究人员的环境； 增加获得技术和资源的机会，以进行严格、有影响力的皮肤研究； 加速将研究成果转化为皮肤病的创新疗法来实现这些目标。 目标，该中心的宗旨是： 目标 1) 提供以尖端方法和相关专业知识为中心的 大约 3 个多学科资源核心：皮肤表型组学和转录组学 (CPAT) 核心、皮肤 转化研究 (STaR) 核心和数据科学与信息学 (DSI) 核心非常重要。 协同作用，提供高需求和/或专业服务、宝贵的组织/细胞资源以及 专业知识，以确保严格的实验设计、分析策略和准确的解释。 利用董事和联合董事及其研究小组的深厚专业知识， 不断改进和创新中心提供的技术/方法 目标 2) 建立一个 统一皮肤研究人员并促进 SBDRC 目标实现的管理核心。 核心负责监督并实施中心的活动，其中包括一项强化计划。 细分为 4 个子核心： 社区外展子核心介绍了服务欠缺的费城 通过宾夕法尼亚大学让公立高中学生对生物医学研究和皮肤病学感到兴奋 皮肤健康学院 (PASH)、周六学院和暑期实习计划也包括这些项目。 为 SBDRC 成员提供志愿者和指导机会； 通过为学员和初级教师提供结构化指导，实现职业成功和培训。 与皮肤科多元化和包容性委员会合作，提供专业指导 将提供针对医学界代表性不足的妇女和少数民族的方案，以及针对 SBDRC 导师赞助了一系列研讨会、讲习班和年度活动。 科学研讨会促进皮肤之间的互动、合作和创新方法 种子资助子核心提供了 3 种不同的资助机制来吸引新的研究人员。 并支持初级研究人员的独立性。宾夕法尼亚大学 SBDRC 利用宾夕法尼亚大学的卓越优势。 皮肤科的研究和临床项目以及整个宾夕法尼亚大学社区的研究和临床项目，以加强 合作，为皮肤研究带来新技术，并提供关键知识和知识的获取 技术资源极大地提高了皮肤病研究的创新性和严谨性。 皮肤研究远远超出了宾夕法尼亚州的边界，并最终推进了治疗、预防和治疗 皮肤病的诊断。