Tanzania AIDS Malignancies Training and Research Program (TAMTRP)

坦桑尼亚艾滋病恶性肿瘤培训和研究计划 (TAMTRP)

• 批准号: 10472142
• 负责人: Julius David Mwaiselage
• 金额: $ 29.36万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10472142
• 关键词: AIDS prevention; AIDS related cancer; Acquired Immunodeficiency Syndrome; Big Data Methods; Bioinformatics; Biology; Biometry; Cancer Biology; Cancer Center; Cancer Detection; Cancer Research Infrastructure; Clinical; Clinical Research; Clinical Trials; Collaborations; Detection; Diagnosis; Diagnostic; Diagnostics Research; Doctor of Philosophy; Educational workshop; Epidemiology; Etiology; Future; Genomics; Goals; Health Personnel; Health Sciences; Human Resources; Immunology; Infrastructure; Institutes; Institution; Instruction; Laboratories; Louisiana; Malignant Neoplasms; Master' s Degree; Mentors; Methodology; Molecular; Molecular Biology; Oceans; Oncology; Pathology; Preparation; Prevention; Public Health; Research; Research Training; Tanzania; Training; Training and Infrastructure; Translational Research; Universities; Viral; anticancer research; base; cancer genomics; cancer prevention; cancer therapy; data management; design; experience; genomic epidemiology; insight; molecular pathology; neoplasm registry; next generation sequencing; precision oncology; programs; training opportunity; virology

Abstract The overall objective of the proposed Tanzania AIDS Malignancies Training and Research Program (TAMTRP) is to enhance the cancer research capacity of the major cancer research institution in Tanzania, the Ocean Road Cancer Institute (ORCI) in partnership with the Stanley S. Scott Cancer Center (SSSCC) at the Louisiana State University Health Science Center in New Orleans (LSUHSC-NO). The proposed program will build onto our existing collaboration, prepare ORCI personnel to fill gaps in expertise while preparing for the future of HIV associated cancer diagnostics and research in cancer genomics and therapy. The scientific focus of TAMTRP is research and training in molecular detection/diagnosis, and in quantifying the epidemiology and biology of the most common HIV associated malignancies in Tanzania, especially those with infectious etiology. The short-term goals are: 1) to enhance the ORCI cancer research and training infrastructure. 2) Institute a training and mentoring program for Tanzanians to conduct research on cancers that are commonly encountered at ORCI and SSSCC. These goals will be accomplished through three specific aims: 1) Provide intensive academic instruction and research experience for two PhD and four Master's degree candidates in a relevant HIV associated cancer research field. 2) Provide medium-term (three to six months) technical training opportunities for post-graduates and health care providers in topics related to molecular pathology, cancer biology, bioinformatics, genomics, biostatistics, bio banking, cancer registry, as well as clinical and translational research. 3) Deliver technical workshops designed to enhance basic, clinical, implementation, genomics, bioinformatics, computation genomics, epidemiology, biostatistics, and continue to expand collaborations between partner institutions to enhance the research capability and infrastructure in Tanzania. There are four training tracks: a) clinical trials methodologies and management; b) public health operational and translational research– including cancer prevention, biostatistics and data management, epidemiology, cancer registry, and bio banking; c) laboratory-based cancer biology research– including molecular biology/virology, pathology, diagnostics, viral oncology, and immunology; d) cancer genomics and bioinformatics–including next generation sequencing, data management, big data analytics, and computational genomics. TAMTRP will be critical in the preparation of ORCI (and Tanzania) for the era of personalized and precision cancer medicine, which will utilize cancer genomics for cancer detection, diagnosis, prevention, and treatment. It will provide important insight in the understanding and prevention of HIV associated and non-HIV associated malignancies in Tanzania, and reciprocally, in the U.S.

抽象的 拟议的坦桑尼亚艾滋病恶性肿瘤培训和研究计划（TAMTRP）的总体目标 旨在增强坦桑尼亚主要癌症研究机构海洋癌症研究能力 道路癌症研究所 (ORCI) 与路易斯安那州斯坦利·斯科特癌症中心 (SSSCC) 合作 新奥尔良州立大学健康科学中心（LSUHSC-NO）。 我们现有的合作，培养 ORCI 人员填补专业知识空白，同时为艾滋病毒的未来做好准备 癌症基因组学和治疗领域的相关癌症诊断和研究是 TAMTRP 的科学重点。 是分子检测/诊断以及量化流行病学和生物学方面的研究和培训 坦桑尼亚最常见的艾滋病毒相关恶性肿瘤，尤其是具有传染性病因的恶性肿瘤。 短期目标是： 1) 加强 ORCI 癌症研究和培训基础设施 2) 研究所。 为坦桑尼亚人开展针对常见癌症的研究提供培训和指导计划 ORCI 和 SSSCC 遇到的这些目标将通过三个具体目标来实现： 1) 提供 为两名博士生和四名硕士生提供密集的学术和研究经验 相关HIV相关癌症研究领域2）提供中期（三至六个月）技术培训。 为研究生和医疗保健提供者提供分子病理学、癌症相关主题的机会 生物学、生物信息学、基因组学、生物统计学、生物银行、癌症登记以及临床和转化 3) 举办旨在加强基础、临床实施、基因组学的技术研讨会。 生物信息学、计算基因组学、流行病学、生物统计学，并持续扩大合作 旨在增强坦桑尼亚研究能力和基础设施的伙伴机构之间有四个。 培训课程：a) 临床试验方法和管理；b) 公共卫生操作和转化 研究——包括癌症预防、生物统计学和数据管理、流行病学、癌症登记和 生物库；c) 基于实验室的癌症生物学研究——包括分子生物学/病毒学、病理学、 诊断、病毒肿瘤学和免疫学；d) 癌症基因组学和生物信息学——包括下一代 测序、数据管理、大数据分析和计算基因组学将至关重要。 ORCI（和坦桑尼亚）为个性化和精准癌症医学时代做好准备，这将 利用癌症基因组学对癌症的检测、诊断、预防和治疗将提供重要的帮助。 深入了解和预防艾滋病毒相关和非艾滋病毒相关恶性肿瘤 坦桑尼亚，反过来，在美国