Next generation training in HIV research: Immunity in the First 1000 days in mother-infant dyads (TIGRIS)

下一代艾滋病毒研究培训：母婴二人最初 1000 天的免疫力 (TIGRIS)

基本信息

批准号：
10471480
负责人：
Rana Chakraborty
金额：
$ 3.02万
依托单位：
STELLENBOSCH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-01 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10471480
关键词：
Accreditation Africa African Basic Science Cameroon Child Childhood Clinic Clinical Clinical Sciences Collaborations Country Development Doctor of Philosophy Educational Curriculum Faculty Felis catus Funding Gabon Ghana Goals Growth HIV HIV Infections Health Immune Immune System Diseases Immunity Immunology Infant International Kenya London Malawi Morehouse School of Medicine Mothers Neonatal Phase Pregnant Women Reproductive Immunology Research Research Institute Research Training Series South Africa Specialist Structure Students Teacher Professional Development Training Training Programs Uganda United States National Institutes of Health Universities adverse birth outcomes college innovation laboratory experience low and middle-income countries medical schools meetings multidisciplinary next generation programs reproductive research study

项目摘要

This application describes the development of an innovative and unique HIV training program entitled: NexT generation traininG in HIV Research: Immunity in the First 1000 days in mother-infant dyadS” (TIGRIS). The program will leverage existing NIH funding to investigate specific hypotheses related to how HIV infection in the pregnant woman leads to adverse birth outcomes and ensuing pediatric immune dysfunction to develop rigorous clinical and basic science laboratory training for mentees. TIGRIS will be a multidisciplinary, international and pan-African HIV training program. The program will be implemented at Stellenbosch University in South Africa along with the Mayo Clinic, Rochester, USA. It will include Training Faculty in the US (Morehouse School of Medicine, Stanford University, Duke University, Weill Cornell Medical College, University of Cincinnati and Seattle Children’s Research Institute), the UK (Imperial College London and University of Oxford) to contribute to a number of research topics that will provide a basis for a more focused D43 HIV training program. The aim of TIGRIS will be to strengthen HIV research by studying reproductive and neonatal immunology in Africa and specifically around health in the mother-infant dyad during maternal HIV infection. This D71 application sets forth a series of immediate goals that will feed into longer terms goals in a subsequent D43 application: 1) Develop a curriculum and structured Post-Graduate Diploma in Reproductive and Neonatal Immunology that would be relevant for MMed (clinical), MSc, and PhD degrees. The program will incorporate preceptors from our assembled expert HIV specialist Faculty at SU and utilize existing HIIV- associated funded projects from our collaborators in the US and UK; 2) Develop a Reproductive Immunology Research Consortium in Africa (RIRCA). Leveraging on training programs, we will create a hub of excellence in reproductive and neonatal immunology research and training that caters for students from low-and-middle- income countries (LMICs) in Africa; 3) Expand and integrate collaborations with other LMIC countries in Africa, where we will initially focus on networking with Cameroon, Benin, Gabon, Ghana, Kenya, Malawi and Uganda. The specific objectives of the D71 planning phase will be to: 1) Hold two Faculty-wide network meetings to define a focused research training program; 2) Develop an accredited reproductive and neonatal immunology curriculum with a strong research training component in placental immunology and neonatal and infant immune ontogeny in the context of maternal HIV infection; 3) Develop a series of short- and long-term training programs; 4) Strengthen and expand inter-African and US partnerships and 5) Submit a D43 application.

该应用程序描述了一项创新且独特的艾滋病毒培训计划的开发，该计划的标题为：下一代艾滋病毒研究培训：母婴二人最初 1000 天的免疫力”（TIGRIS）。该计划将利用现有的 NIH 资金来调查与 HIV 感染如何相关的具体假设孕妇会导致不良的分娩结果并导致儿童免疫功能障碍对学员进行严格的临床和基础科学实验室培训。国际和泛非艾滋病毒培训计划该计划将在斯泰伦博斯实施。南非大学和美国罗切斯特梅奥诊所将包括培训教师。美国（莫尔豪斯医学院、斯坦福大学、杜克大学、威尔康奈尔医学院、辛辛那提大学和西雅图儿童研究所），英国（伦敦帝国理工学院和牛津大学）为许多研究课题做出贡献，这将为更有针对性的研究奠定基础 D43 HIV 培训计划 TIGRIS 的目标是通过研究生殖和艾滋病毒来加强 HIV 研究。非洲新生儿免疫学，特别是孕产妇艾滋病毒感染期间母婴二人的健康此 D71 申请提出了一系列近期目标，这些目标将纳入长期目标。随后的 D43 申请： 1) 开发生殖和生殖领域的课程和结构化研究生文凭与医学硕士（临床）、理学硕士和博士学位相关的新生儿免疫学该项目将。吸收来自我们在 SU 聚集的专家 HIV 专家教师的导师，并利用现有的 HIIV- 我们在美国和英国的合作者资助的相关项目；2) 开发生殖免疫学；借助非洲研究联盟 (RIRCA)，我们将创建一个卓越中心。生殖和新生儿免疫学研究和培训，适合中低收入学生非洲低收入国家 (LMIC)；3) 扩大和整合与非洲其他低收入国家的合作，我们最初将重点关注与喀麦隆、贝宁、加蓬、加纳、肯尼亚、马拉维和乌干达 D71 规划阶段的具体目标是： 1) 建立两个全学院网络会议确定重点研究培训计划； 2) 制定经过认可的生殖和新生儿免疫学课程，具有胎盘免疫学和新生儿和新生儿免疫学方面强大的研究培训内容母亲艾滋病毒感染背景下的婴儿免疫个体发育；3) 制定一系列短期和长期免疫方案；培训计划；4) 加强和扩大非洲和美国之间的伙伴关系；5) 提交 D43 申请。