Admin Core

管理核心

基本信息

批准号：
10470362
负责人：
Jean-Pierre J. Issa
金额：
$ 40.02万
依托单位：
CORIELL INSTITUTE FOR MEDICAL RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-16 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10470362
关键词：
Address Administrator Advocate Award Cancer Prognosis Clinic Clinical Clinical Trials Collaborations Communication Complex Consultations Data Decision Making Development Electronic Mail Eligibility Determination Ensure Genomics Government Grant Infrastructure Institutes Interdisciplinary Study Laboratories Leadership Malignant Neoplasms Medical Research Minority Monitor National Cancer Institute Outcome Pathology Patients Policies Preparation Progress Reports Protocols documentation Publications Quality Control Regulation Reporting Research Research Activity Research Infrastructure Research Personnel Research Project Grants Resource Sharing Strategic Planning Supervision Therapeutic Studies Time Translational Research United States National Institutes of Health Woman Work base cancer care cancer therapy career clinical research site data sharing design epigenetic therapy experience improved interdisciplinary collaboration lectures meetings novel novel therapeutic intervention programs quality assurance recruit screening success symposium web site

项目摘要

PROJECT SUMMARY The Administrative Core will provide essential support to the Coriell Institute for Medical Research (Coriell) and Van Andel Institute (VAI) Epigenetic Therapy SPORE PIs and investigators to maximize success. It will be co- directed by Drs. Jean-Pierre Issa, Stephen Baylin, and Peter Jones, who co-chair the Executive Committee and provide overall supervision of three Projects, two additional Cores, Developmental Research (DRP) and Career Enhancement (CEP) Programs, and scientific direction of the SPORE. The Core Co-Directors will rely on the extensive broad-based scientific, research, and SPORE experience of the Internal and External Advisory Boards in critical decision making. An oversight committee consisting of the SPORE PIs and three clinical experts from the VAI-SU2C team (Drs. Rudin, El-Khoueiry and O’Connell) will ensure prioritization of SPORE trials within the VAI-SU2C team and at clinical sites. Success of the complex interdisciplinary research in the SPORE depends on integration of diverse epigenetic therapy research approaches. The Core will overcome barriers to interdisciplinary collaboration and data sharing and will ensure a unified translational research effort. The SPORE will be founded on planning, integration, and translational research efforts supported by this Core. Its leadership and staff will be responsible for monitoring/planning scientific activities; providing scientific direction; ensuring emphasis on translational research; ensuring interdisciplinary and inter-SPORE integration with major epigenetic therapy programs within/outside Coriell and VAI and other broad translational research activities; and providing optimal administrative and fiscal management. Specific responsibilities of the Core are: oversee and monitor all SPORE activities; promote integration and communication among the SPORE-related clinical programs; monitor the scientific integrity of all projects, and grant awards; assure compliance with institutional, governmental, and National Cancer Institute regulations; oversee the fiscal and budgetary activities of the SPORE; coordinate data control quality assurance issues; coordinate activities associated with clinical trials, including design of protocols, approval by regulatory bodies, implementation, and eligibility screening and assignment of patients to different studies; provide oversight and support for the shared Resources Cores; coordinate and manage meetings of the SPORE Oversight Committee, Executive Committee, Internal and External Advisory Boards, investigator meetings, research meetings, lectures, and symposia; administer the DRP and the CEP; coordinate interdisciplinary and inter-SPORE interactions and exchanges/meetings with other Epigenetic Therapy SPORE programs and investigators, and other SPORE programs; administer the activities of the Patient Advocates; comply with, and improve policies addressing recruitment and retention of women and minorities; and maintain a Epigenetic Therapy SPORE website focused on issues in epigenetic therapy translational research in cancers.

项目概要行政核心将为科里尔医学研究所 (Coriell) 和范安德尔研究所 (VAI) 表观遗传治疗 SPORE PI 和研究人员将共同努力取得最大成功。由执行委员会联合主席 Jean-Pierre Issa、Stephen Baylin 和 Peter Jones 博士指导提供对三个项目、两个附加核心、发展研究 (DRP) 和职业的全面监督 SPORE 的增强 (CEP) 计划和科学方向将依赖于 SPORE。内部和外部顾问委员会拥有广泛的科学、研究和 SPORE 经验一个由 SPORE PI 和三名临床专家组成的监督委员会。 VAI-SU2C 团队（Rudin、El-Khoueiry 和 O’Connell 博士）将确保 SPORE 试验在 VAI-SU2C 团队和 SPORE 中复杂的跨学科研究的成功取决于临床现场。整合不同的表观遗传治疗研究方法将克服障碍。跨学科合作和数据共享，将确保统一的转化研究工作。将建立在该核心领导层支持的规划、整合和转化研究工作的基础上。工作人员将负责监测/规划科学活动，确保提供科学指导；强调转化研究；确保跨学科和孢子间与主要表观遗传学的整合 Coriell 和 VAI 内部/外部的治疗计划以及其他广泛的转化研究活动；核心的具体职责是：监督和监督所有工作。 SPORE 活动；促进 SPORE 相关临床项目之间的整合和交流；所有项目的科学完整性，并确保遵守机构、政府和机构的规定；国家癌症研究所法规；监督 SPORE 协调数据的财政和预算活动；控制质量保证问题；协调与临床试验相关的活动，包括方案设计，监管机构的批准、实施、资格筛选和将患者分配到不同的机构研究；为共享资源核心提供监督和支持； SPORE 监督委员会、执行委员会、内部和外部顾问委员会、调查员会议、研究会议、讲座和研讨会；管理 DRP 和 CEP；与其他表观遗传治疗 SPORE 的跨学科和 SPORE 之间的互动和交流/会议计划和调查员以及其他 SPORE 计划；管理患者权益倡导者的活动；遵守并改进有关招聘和保留妇女和少数族裔的政策；表观遗传治疗 SPORE 网站专注于癌症表观遗传治疗转化研究的问题。