Kinematic and Acoustic Analysis of Speech in Autism Spectrum Disorder

自闭症谱系障碍患者言语的运动学和声学分析

• 批准号: 10469341
• 负责人: Marc Maffei
• 金额: $ 4.29万
• 依托单位: MGH INSTITUTE OF HEALTH PROFESSIONS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-12 至 2024-08-11
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10469341
• 关键词: 5 year old; Acoustics; Address; Affect; Age; Area; Articulation; Auditory; Characteristics; Child; Clinical; Communication; Data; Decision Making; Development; Disease; Early Diagnosis; Exhibits; Funding; Genetic Transcription; Goals; Heterogeneity; Human Resources; Impairment; Individual; Intervention; Knowledge; Language; Language Disorders; Literature; Methodology; Methods; Modeling; Motion; Motivation; Motor; Motor Skills; Movement; National Institute on Deafness and Other Communication Disorders; Optics; Pattern; Performance; Pervasive Development Disorder; Population; Reporting; Research; Residual state; Sample Size; Severities; Speech; Speech Disorders; Speed; Standardization; Structure; System; Technology; Testing; United States; Voice; autism spectrum disorder; autistic children; base; clinical decision-making; comparison group; design; individuals with autism spectrum disorder; innovation; kinematics; language impairment; language outcome; motor control; motor deficit; motor impairment; multimodality; neurobiological mechanism; novel; peer; phrases; programs; research clinical testing; skills; standardize measure

PROJECT SUMMARY Deficits in speech and language skills are well documented in children with autism spectrum disorder (ASD), a pervasive developmental disorder that affects 1 in 54 children in the United States. Despite the wide range of deficits and the debilitating effect of language impairments, the factors influencing divergent language outcomes in this population remain unknown, and the range of articulatory skills has not been adequately documented. The current study investigates the hypothesis that children with ASD exhibit abnormal articulatory motor control relative to same-age peers based on the premise that (1) it is well established that children with ASD have global motor control deficits, including impairments in both gross and fine motor skills, (2) less is known about their oromotor status, although existing studies have implicated oromotor deficits, and (3) research suggests that oromotor deficits predict poor language outcomes. We will use a comprehensive framework of kinematic and acoustic features representing five key components of articulatory motor control (i.e., coordination, consistency, precision, speed, and rate) to objectively quantify speech skills in children with ASD age 5;0 to 7;11. Motivation for using these features comes from gross motor, fine motor, and articulatory motor literature; however, this study would be the first to combine them in a comprehensive account of articulatory abilities in ASD, and among the first to use optical motion capture technology to assess speech in this population. Data obtained in the proposed project will be compared to normative data from typically developing children in the same age range being collected in a related study. The instrumental assessment of articulatory motor control will provide results that are more reliable and less vulnerable to bias than commonly used perceptual methods. To determine if severity of articulatory deficits predicts concurrent speech and expressive language abilities among children with ASD while controlling for age and non-verbal IQ, we will then examine each feature’s relationship to scores on standardized measures of articulation and expressive language. The findings of this study are critical to (1) furthering our understanding of language deficits in ASD, (2) informing clinical decision-making regarding the use of articulation-based therapies in conjunction with language-based therapies for children with ASD, and (3) addressing ongoing clinical and scientific issues including early detection of ASD and the identification of neurobiological mechanisms influencing communication development.

项目概要 患有谱系障碍（ASD）的儿童自闭症患者在言语和语言技能方面存在缺陷，这是有据可查的。 尽管影响范围广泛，但美国每 54 名儿童中就有 1 人患有广泛性发育障碍。 语言障碍的缺陷和破坏性影响，影响不同语言结果的因素 该人群的发音能力仍然未知，而且发音技能的范围也没有得到充分记录。 目前的研究调查了自闭症儿童表现出异常的关节运动控制的假设 相对于同龄同龄人，基于以下前提：(1) 众所周知，患有自闭症谱系障碍 (ASD) 的儿童具有全球性的 运动控制缺陷，包括粗大运动技能和精细运动技能受损，（2）对其的了解较少 口运动状态，尽管现有研究表明存在口运动缺陷，并且 (3) 研究表明 口部运动缺陷预示着较差的语言结果。 代表发音运动控制五个关键组成部分的声学特征（即协调性、一致性、 精确度、速度和速率）来客观量化 5;0 至 7;11 岁自闭症谱系障碍儿童的言语技能。 使用这些功能来自粗大运动、精细运动和关节运动文献； 这项研究将是第一个将它们结合起来对自闭症谱系障碍（ASD）患者的发音能力进行全面描述的研究。 第一个使用光学动作捕捉技术来评估该人群中获得的语​​音数据。 拟议项目将与同一年龄范围内典型发育儿童的规范数据进行比较 相关研究中收集的关节运动控制的仪器评估将提供结果。 比常用的感知方法更可靠且更不易受到偏见的影响。 发音缺陷的严重程度可预测患有以下疾病的儿童的并发言语和表达语言能力 ASD 在控制年龄和非语言智商的同时，我们将检查每个特征与分数的关系 这项研究的结果对于（1）至关重要。 加深我们对 ASD 语言缺陷的理解，(2) 为有关自闭症谱系障碍 (ASD) 的临床决策提供信息 对自闭症谱系障碍儿童使用基于发音的疗法与基于语言的疗法相结合，以及 (3) 解决持续存在的临床和科学问题，包括自闭症谱系障碍 (ASD) 的早期检测和识别 影响沟通发展的神经生物学机制。