Collaborative Pediatric Critical Care Research Network - Clinical Site

儿科重症监护协作研究网络 - 临床网站

• 批准号: 10468852
• 负责人: Marie E Steiner
• 金额: $ 8.24万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-13 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10468852
• 关键词: Address; Admission activity; Advisory Committees; Anti-Inflammatory Agents; Asian population; Beds; Bioinformatics; Cardiac; Caring; Certification; Child; Child Health; Childhood; Childhood Injury; Clinical; Clinical Research; Clinical Trials; Collaborations; Collection; Communicable Diseases; Communities; Complement; Contracts; Critical Care; Critical Illness; Critically ill children; Data; Data Coordinating Center; Development; Devices; Discipline of Nursing; Doctor of Philosophy; Ebola; Ebola virus; Economics; Enrollment; Ethics; Ethnic Origin; Faculty; Family; Fellowship; Functional disorder; Future; Good Clinical Practice; Grant; Granulocyte-Macrophage Colony-Stimulating Factor; Health; Hematology; Illness impact; Immunophenotyping; Individual; Infection prevention; Institution; International; Intubation; Knowledge; Leadership; Manuscripts; Measures; Medical; Medicine; Mentors; Mentorship; Midwestern United States; Minnesota; Mission; Multicenter Trials; Multiple Organ Failure; National Institute of Child Health and Human Development; Native Americans; Nosocomial Infections; Observational Study; Oncology; Operative Surgical Procedures; Organ; Organ Donations; Organ Transplantation; Outcome; Patient Recruitments; Patients; Pediatric Acute Lung Injury; Pediatric Hospitals; Pediatric Intensive Care Units; Pennsylvania; Performance; Pharmacologic Substance; Pharmacy facility; Population; Positioning Attribute; Principal Investigator; Procedures; Protocols documentation; Public Health; Race; Recording of previous events; Recovery; Registries; Research; Research Personnel; Research Training; Respiratory Therapy; Role; Running; Scientist; Sepsis; Services; Site; Socioeconomic Status; System; Talents; Time; Training; Translational Research; Trauma; United States; Universities; University resources; Work; ancillary care; base; clinical center; clinical research site; dietary; disability; expectation; experience; health care service organization; health related quality of life; immune function; immunoregulation; immunosuppressed; industry partner; innovation; interest; knowledge base; meetings; member; organizational structure; participant enrollment; pathogen; patient population; pediatric department; pediatric sepsis; product development; racial and ethnic; sample collection; severe injury; skills; social; socioeconomics; southeast Asian; success; surgical service; translational study; treatment center; venous thromboembolism

PROJECT SUMMARY/ABSTRACT – University of Minnesota The Collaborative Pediatric Critical Care Research Network (CPCCRN) has been critical in building the knowledge base of pediatric critical care medicine. The overall aim of this site proposal is for the University of Minnesota Masonic Children's Hospital (UMMCH), under the leadership of Site Principal Investigator, Marie Steiner, MD, MS, to join this expanded iteration of CPCCRN. UMMCH is a free-standing, quaternary care, academic children's hospital located in Minneapolis, MN, serving children and families across a diverse range of racial, ethnic, and socioeconomic backgrounds. It has a 24-bed mixed medical/surgical and cardiac pediatric intensive care unit and offers the full spectrum of pediatric and surgical subspecialty services. UMMCH has a strong history of clinical research and innovation in conjunction with the resources of the University of Minnesota, the state's land grant university. Pediatric critical care research includes numerous completed and ongoing studies championed by multiple faculty, including the Co-Investigators for this grant. With increasing support from internal and external grants and the development of the Pediatric Device Innovation Center, the Division was third in the Department in launching new studies in 2019, behind Hematology/Oncology and HSCT. Children's Minnesota (Children's) will serve as our Ancillary Site under the leadership of Alberto Orioles, MD. Children's is a not-for-profit, freestanding children's hospital also located in Minneapolis, with a long-standing history of participation in critical care research, including several CPCCRN studies. Together, UMMCH and Children's will provide access to 55 pediatric ICU beds and over 3500 annual admissions, which captures the majority of critically ill children throughout the Upper Midwest and will facilitate participation in large clinical trials. The proposed “Personalized Immunomodulation in Sepsis-Induced Multiple Organ Dysfunction Syndrome (MODS)” trial addresses the hypothesis that immunosuppressed children will benefit from administration of granulocyte macrophage-colony stimulating factor and that children with hyperinflammation will benefit from targeted anti-inflammatory therapy. Benefit will be evaluated in terms of recovery from MODS, as well as short- and long-term health-related quality of life measures. This partnership has the knowledge and skills to successfully complete this trial, including sample collection and processing for immunophenotyping and collection of short- and long-term outcomes. Drs. Steiner and Orioles have the full support of their respective institutions to participate in CPCCRN and to prioritize patient recruitment and accrual to its studies. The institutions are strongly committed to collaboration with CPCCRN sites and the Data Coordinating Center to conduct the proposed and future research. Our clinical center and ancillary site will provide local mentorship for our highly talented young faculty and will support their participation in the central CPCCRN mentoring activities that are described in Section B.3 of the required CPCCRN Network Organizational Structure attachment to the Overall Component of this PL1 application.

项目摘要/摘要 - 明尼苏达大学 儿科重症监护协作研究网络 (CPCCRN) 在建立 该网站提案的总体目标是为儿科重症监护医学知识库。 明尼苏达共济会儿童医院 (UMMCH)，在现场首席研究员 Marie 的领导下 Steiner，医学博士，理学硕士，加入 CPCCRN 的扩展迭代是一个独立的四级护理， 位于明尼苏达州明尼阿波利斯的学术儿童医院，为不同范围的儿童和家庭提供服务 它拥有 24 个混合内科/外科和心脏儿科床位。 UMMCH 设有重症监护病房，提供全方位的儿科和外科专科服务。 结合大学的资源，拥有悠久的临床研究和创新历史 明尼苏达州，该州的赠地大学儿科重症监护研究包括许多已完成和完成的研究。 包括这项资助的联合研究人员在内的多位教师支持正在进行的研究。 来自内部和外部拨款的支持以及儿科设备创新中心的发展， 2019 年，该部门在开展新研究方面位居全科第三位，仅次于血液学/肿瘤学和 明尼苏达儿童医院 (HSCT) 将在 Alberto 的领导下作为我们的辅助中心。 马里兰州金莺儿童医院是一家非营利性独立儿童医院，也位于明尼阿波利斯，拥有一家医院。 长期参与重症监护研究，包括多项 CPCCRN 研究。 UMMCH 和儿童医院将提供 55 张儿科 ICU 床位，每年可接待 3500 多名住院患者， 捕获了整个中西部北部地区的大多数危重儿童，并将促进他们参与 拟议的“脓毒症引起的多器官的个性化免疫调节”。 功能障碍综合症（MODS）”试验提出了免疫抑制儿童将受益的假设 粒细胞巨噬细胞集落刺激因子的施用和儿童 过度炎症将从靶向抗炎治疗中获益，获益将根据以下方面进行评估。 MODS 的康复，以及与健康相关的短期和长期生活质量措施。 具备成功完成本试验的知识和技能，包括样品采集和处理 Steiner 和 Orioles 博士拥有完整的免疫表型分析和短期和长期结果的收集。 支持各自机构参与 CPCCRN 并优先考虑患者招募和 这些机构坚定地致力于与 CPCCRN 站点和数据的合作。 协调中心将开展拟议的和未来的研究。 为我们才华横溢的年轻教师提供当地指导，并支持他们参与中央研究 所需 CPCCRN 网络 B.3 节中描述的 CPCCRN 指导活动 此 PL1 应用程序整体组件的组织结构附件。