NEW THERAPEUTIC APPROACHES FOR MALIGNANT GLIOMA

恶性胶质瘤的新治疗方法

• 批准号: 2100844
• 负责人: LYNN G FEUN
• 金额: $ 7.8万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-05-01 至 1996-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2100844
• 关键词: glioma; neoplasm /cancer chemotherapy; neoplasm /cancer pharmacology; neoplasm /cancer radiation therapy

The treatment of patients with malignant glioma continues to be a challenge. The goal of this research program is to develop new therapeutic approaches for malignant glioma. This program project consists of three projects and one core unit. One project is designed to study the effects of variation of radiation dose rates on human glioma cells and may lead to a better understanding of the optimal radiation dose rate to use either alone or when combined with chemotherapy. A second project explores the role of cytokines in producing brain edema and possible techniques to control brain edema. The third project investigates the role of peripheral-type benzodiazepine receptors in the proliferation, differentiation, and cell cycle kinetics of malignant glioma and their potential interactions with chemotherapy and cytokines. The core unit will be responsible for establishing and maintaining malignant glioma cell lines. In addition, the core unit will also collect brain tumor samples from patients, isolate DNA and RNA from tumor and obtain molecular genetic data from patients' tumors as well s their cell lines. Together, these investigations may lead to improvement in the efficacy in current treatment for malignant glioma while reducing potential neurotoxicity from therapy. These projects along with the potential strengths of our Center form the basis for the development of a Brain Tumor Research Center.

恶性胶质瘤患者的治疗仍然是一个难题 挑战。 该研究计划的目标是开发新的 恶性胶质瘤的治疗方法。 本计划项目 由三个项目和一个核心单元组成。 设计了一个项目 研究辐射剂量率变化对人类神经胶质瘤的影响 细胞，并可能有助于更好地了解最佳辐射 单独使用或与化疗联合使用的剂量率。 一个 第二个项目探讨细胞因子在产生脑水肿中的作用 以及控制脑水肿的可能技术。 第三个项目 研究外周型苯二氮卓受体在 恶性细胞的增殖、分化和细胞周期动力学 神经胶质瘤及其与化疗和细胞因子的潜在相互作用。 核心单位将负责建立和维护 恶性神经胶质瘤细胞系。 此外，核心单元还将 采集患者脑肿瘤样本，从肿瘤中分离DNA和RNA 并从患者的肿瘤及其自身组织中获取分子遗传数据 细胞系。 总之，这些调查可能会导致改善 目前治疗恶性胶质瘤的疗效，同时减少 治疗的潜在神经毒性。 这些项目连同 中心的潜在优势构成了中心发展的基础 脑肿瘤研究中心。