RECEPTIVE FIELDS OF LAYER IV (BARREL FIELD) NEURONS

第四层（桶状场）神经元的感受野

• 批准号: 2265714
• 负责人: Ford Francis Ebner
• 金额: $ 11.89万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-25 至 1994-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2265714
• 关键词: NMDA receptors; brain electrical activity; histology; laboratory rat; microscopy; neocortex; neural information processing; neuroanatomy; neuropharmacology; neurophysiology; sensory feedback; somesthetic sensory cortex; stimulus /response; synapses; thalamocortical tract

Sensory systems in mammals consist of multiple pathways from the peripheral receptors to neocortex. Of these, only one is organized for transmitting the precise physical characteristics of sensory stimuli. The proposed experiments are designed to show the organization and function of parallel somatic sensory pathways. Preliminary results indicate that, of the multiple somatic pathways carrying information from the whiskers to the barrel field cortex of rat, only the 'lemniscal' pathway through the medial subdivision of the thalamic ventral posterior nucleus (VPM) is capable of maintaining the sensory responsiveness of neurons in the barrel field. The general thesis is that the 'paralemniscal' pathway through the thalamic posterior nucleus (PO), terminating in septa surrounding cortical barrels, regulates the excitability of septal neurons; by modulating the horizontal distance in cortex across which activity spreads, PO controls the degree of interaction and association between inputs from VPM terminating in separate barrels. To test this hypothesis, we will identify with anatomical transport methods the locations in cortex at which lemniscal and paralemniscal inputs converge. Then we will measure the effect of stimulation of PO on the magnitude and horizontal spread of cortical activity evoked by movement of a single whisker. The PO stimulation will be delivered either synchronously with whisker movement or out of phase with whisker movement. We will then measure the influence of PO stimulation on the plasticity of cortical receptive fields induced by temporally paired movement of whiskers. Finally, we will investigate the role of glutamate receptors in barrel field receptive field plasticity.

哺乳动物的感觉系统由周围的多个途径组成 新皮层的受体。 其中，只有一个用于传输 感觉刺激的精确物理特征。 提议 实验旨在显示并行的组织和功能 体感觉途径。 初步结果表明， 多个躯体途径，从晶须到 老鼠的桶形田地皮层，只有内侧的“ lemaniscal”途径 丘脑腹侧后核（VPM）的细分能够 保持枪管场中神经元的感觉反应能力。 这 一般性论点是，通过丘脑的“同性恋”途径 后核（PO），终止于围绕皮质桶的隔膜， 调节间隔神经元的兴奋性；通过调节水平 PO控制活动的皮质的距离 从VPM终止的输入之间的相互作用和关联 单独的桶。为了检验这一假设，我们将通过解剖学识别 运输方法在lemesiscal和 同性赛事输入汇聚。然后，我们将衡量 刺激PO在皮质的大小和水平扩散上 单个晶须运动引起的活动。 PO刺激将 与晶须运动同步交付或相位交付 带有晶须运动。 然后，我们将衡量PO的影响 刺激由诱导的皮质接受场的可塑性 暂时配对的胡须运动。 最后，我们将调查 谷氨酸受体在枪管场接受场可塑性中的作用。