Core A: Administrative Core

核心A：行政核心

• 批准号: 10463732
• 负责人: Justin D. Lathia
• 金额: $ 12.92万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-14 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10463732
• 关键词: Accounting; Animal Experimentation; Animals; Awareness; Bioinformatics; Biometry; Cancer Biology; Collaborations; Communication; Core Facility; Data; Data Set; Development Plans; Documentation; Drug Screening; Ensure; Epigenetic Process; Experimental Models; Feedback; Funding; Glioma; Goals; Grant; Human; Human Resources; Human Subject Research; Individual; Institution; Iron; Leadership; Manuscripts; Microglia; Modeling; Monitor; National Cancer Institute; Office of Administrative Management; Oral; Performance; Postdoctoral Fellow; Preparation; Program Research Project Grants; Progress Reports; Research; Research Personnel; Resources; Schedule; Scientist; Services; Sex Differences; Study Subject; System; Time; Training; Work; base; drug metabolism; experience; human subject; innovation; meetings; operation; programs; recruit; sex; stem; tumor microenvironment

PROJECT SUMMARY The Administrative Core is responsible for the overall leadership and management of the Program Project Grant (P01), and it will provide overall organizational, administrative, and scientific management. The Administrative Core will oversee and coordinate all P01 components and centrally monitor and evaluate their performance. In addition, the Administrative Core will facilitate all interactions with the Internal Advisory Board (IAB) and External Advisory Board (EAB). This P01 application involves 6 institutions and 5 key investigators, as Project and Core leaders. The Administrative Core will be essential in coordinating all communications and reviewing all activities among Projects and Cores that will take place across the participating institutions. The Administrative Core will administer all the subcontracts, work closely with all participating institutions in order to use existing facilities and build upon those when required, and ensure that best practices for animal studies and human subjects research are met and monitored appropriately. It will additionally ensure that access to all scientific core facility services are managed to ensure that the overall goals of the P01 are met. The Administrative Core personnel will be led by Dr. Lathia, with collaboration from Drs. Barnholtz-Sloan and Waite and Ms. Schiciano. Both Drs. Lathia and Barnholtz-Sloan have extensive experience in managing multi-institution programs. The proposed P01 team has a successful record of accomplishment of working together on multiple collaborative efforts. The Specific Aims are:1) To provide all organizational, administrative, and scientific leadership for the P01 Projects and Cores by cultivating and promoting the P01 team through innovation and excellence, leveraging resources, and providing constructive feedback; 2) To provide administrative management for all fiscal management of the P01 including but not limited to accounting of grant funds, progress reports, communication, meeting scheduling and minutes, and manuscript and grant preparation; 3) To evaluate research progress through oral and written documentation, with regular input from the IAB, EAB, and National Cancer Institute (NCI) leadership in order to ensure that each project is meeting its objectives within the proposed time frame; 4) To ensure and monitor best practices for human subjects and animal research for all P01 Projects and Cores; data operations (in collaboration with the Biostatistics and Bioinformatics Core); and adequate human and animal biospecimens for all projects (in collaboration with the Experimental Models Core); and 5) To raise awareness of the P01 through promotion of seminars, recruitment of postdoctoral fellows, scientific exchanges, coordination of an annual scientific retreat involving the scientists in the P01, and through training and development plans that will ensure state-of-the-art practices.

项目概要 行政核心负责计划项目资助的总体领导和管理 （P01），提供全面的组织管理、行政管理、科学管理。行政部门 Core 将监督和协调所有 P01 组件，并集中监控和评估其性能。在 此外，行政核心将促进与内部顾问委员会 (IAB) 和外部顾问委员会的所有互动 顾问委员会（EAB）。本次P01申请涉及6家机构和5名重点研究者，分别为项目和核心 领导人。行政核心对于协调所有沟通和审查所有活动至关重要 将在参与机构中进行的项目和核心。行政核心将 管理所有分包合同，与所有参与机构密切合作，以便使用现有设施和 必要时以这些为基础，并确保动物研究和人类受试者研究的最佳实践 得到适当满足和监控。它还将确保获得所有科学核心设施服务 进行管理，以确保实现 P01 的总体目标。行政核心人员将由 由 Lathia 博士与 Drs 合作完成。巴恩霍尔茨-斯隆、韦特和斯基西亚诺女士。两位博士。拉西亚和 巴恩霍尔茨-斯隆在管理多机构项目方面拥有丰富的经验。拟议的 P01 团队有 共同完成多项协作工作的成功记录。具体目标 是：1) 为 P01 项目和核心提供所有组织、行政和科学领导 通过创新和卓越，培养和提升P01团队，利用资源，提供 建设性反馈； 2）为P01的所有财务管理提供行政管理，包括 但不限于赠款资金的会计、进度报告、沟通、会议安排和会议记录， 以及手稿和资助准备； 3）通过口头和书面文件评估研究进展， 定期听取 IAB、EAB 和国家癌症研究所 (NCI) 领导层的意见，以确保每个 项目正在提议的时间范围内实现其目标； 4) 确保并监控最佳实践 所有 P01 项目和核心的人类受试者和动物研究；数据操作（与 生物统计学和生物信息学核心）；以及所有项目的足够的人类和动物生物样本（在 与实验模型核心的合作）； 5) 通过宣传提高对 P01 的认识 研讨会、博士后招募、科学交流、年度科学务虚会的协调 让科学家参与 P01，并通过培训和发展计划确保最先进的 做法。