Administrative Core

行政核心

基本信息

批准号：
10461082
负责人：
DAVID A WOLK
金额：
$ 48.98万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-15 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10461082
关键词：
Address Advisory Committees Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Applications Grants Behavioral Research Biocompatible Materials Caring Charge Clinical Clinical Trials Collaborations Community Health Education Data Dementia Development Diagnosis Discipline Disease Early Onset Alzheimer Disease Education Education and Outreach Elderly Enrollment Ensure Epidemiology Event Eye Faculty Family Feedback Fostering Genetic Diseases Goals Grant Growth Human Subject Research Individual Infrastructure Institutes Institution International Leadership Link Mission Monitor Nerve Degeneration Neurodegenerative Disorders Neurosciences Participant Persons Phenotype Positioning Attribute Postdoctoral Fellow Procedures Process Reagent Recommendation Recruitment Activity Reporting Research Research Personnel Research Training Role Science Series Students Teacher Professional Development Techniques United States National Institutes of Health Work brain health career development data dissemination data sharing design disease heterogeneity education research improved innovation lectures meetings member multidisciplinary neuroimaging next generation normal aging novel operation programs repository success

项目摘要

Administrative Core Project Summary The primary goal of the Penn ADRC is to increase research and education on Alzheimer’s disease (AD) and its links to related disorders (ADRD) across the continuum of normal aging to dementia with the goal of identifying the causes of and cures for AD/ADRD. To achieve this goal, the Penn ADRC coordinates research programs, stimulates new research, catalyzes academic research training, provides community education and outreach and fosters the development of novel techniques to individualize diagnosis and treatment for the benefit of all elderly persons and their families. It is the role of the Administrative Core to shepherd and facilitate the activities of the ADRC Cores and to serve as a bridge between the ADRC and national and international efforts in pursuit of these goals. Administrative Core will be involved in a number of different activities that are designed to achieve these broad goals, including fiscal and administrative oversight over the ADRC (Aim 1). The leaders of the ADRC and the ADRC Executive Committee, composed of core leaders and co-leaders, will set priorities and develop plans to achieve ADRC goals. The Administrative Core will choose members of an External Advisory Committee that will be charged with the role of evaluating the progress of the Center and providing recommendations (Aim 2). A variety of forums and opportunities for exchange of ideas and dissemination of data will be supported by the Administrative Core through ADRC sponsored retreats and lecture series (Aim 3). These events will include participation of faculty and trainees, providing an opportunity, particularly for the latter, to present data and receive feedback. Critical to the growth and breadth of AD/ADRC research, a unique Developmental Project program linked to topics at annual retreats will foster transdisciplinary work (Aim 4). The Administrative Core will champion participation of the Penn ADRC in numerous state, national, and international efforts to improve care and treatment of ADRD, as well as provide infrastructure to support the sharing of data and biomaterials (Aim 5). Finally, the core will provide oversight on all NIA and local regulatory and reporting procedures and requirements (Aim 6). Critically, the Administrative Core serves to maintain the “centeredness” of the ADRC by coordinating efforts across the individual cores, by promoting collaborations with other neurodegenerative centers at Penn and beyond, and by promoting activities consistent with our thematic focus around AD heterogeneity. By achieving the above aims, we expect to maintain our highly productive ADRC with the appropriate support to do novel research, to contribute highly and deeply phenotyped individuals to larger data sharing efforts, to grow our diverse and multi-disciplinary faculty by training the next generation of investigators and clinicians, and to educate and empower our region and the nation so as to improve brain health and meet the goals of NAPA.

行政核心项目概要宾夕法尼亚州 ADRC 的主要目标是加强对阿尔茨海默病 (AD) 及其相关疾病的研究和教育从正常衰老到痴呆的整个过程中与相关疾病 (ADRD) 的联系，目的是识别 AD/ADRD 的原因和治疗方法为了实现这一目标，宾夕法尼亚大学 ADRC 协调研究项目，刺激新研究，促进学术研究培训，提供社区教育和推广并促进新技术的发展，以实现个体化诊断和治疗，造福所有人行政核心的职责是引导和促进老年人及其家人的生活。 ADRC 核心活动，并充当 ADRC 与国家和国际努力之间的桥梁为了实现这些目标。行政核心将参与许多旨在实现这些目标的不同活动广泛的目标，包括对 ADRC 的财政和行政监督（目标 1）。 ADRC执行委员会由核心领导人和联合领导人组成，将确定优先事项并制定计划实现 ADRC 目标。行政核心将选择外部顾问成员。委员会将负责评估中心的进展并提供建议（目标 2）。交流思想和传播建议的各种论坛和机会。数据将由行政核心通过 ADRC 赞助的务虚会和系列讲座（目标 3）提供支持。这些活动将包括教师和学员的参与，特别是为后者对 AD/ADRC 研究的发展和广度至关重要，这是一种独特的方式。与年度静修主题相关的发展项目计划将促进跨学科工作（目标 4）。行政核心将支持宾大 ADRC 在许多州、国家和地区的参与国际社会努力改善 ADRD 的护理和治疗，并提供基础设施来支持最后，该核心将对所有 NIA 和地方监管机构进行监督。报告程序和要求（目标 6）。至关重要的是，行政核心通过协调努力来维持 ADRC 的“中心地位” 通过促进与宾夕法尼亚大学和其他神经退行性中心的合作，跨越各个核心超越，并通过促进与我们围绕 AD 异质性的主题重点相一致的活动。为了实现上述目标，我们希望在适当的支持下保持 ADRC 的高生产力，以开展新颖的工作研究，为更大规模的数据共享工作做出高度和深入的表型个人贡献，以发展我们的通过培训下一代调查员和裁判员来培养多元化和多学科的教师队伍，并教育并赋予我们地区和国家权力，以改善大脑健康并实现 NAPA 的目标。