Exploring dopamine function during naturalistic behavior

探索自然行为中的多巴胺功能

• 批准号: 10460158
• 负责人: Sandeep R Datta
• 金额: $ 81.44万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-15 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10460158
• 关键词: 3-Dimensional; Animal Behavior; Animal Disease Models; Animals; Axon; Basal Ganglia; Behavior; Behavioral; Code; Corpus striatum structure; Cues; Dopamine; Environment; Feedback; Food; Future; Individual; Learning; Midbrain structure; Monitor; Motion; Motivation; Motor; Movement; Mus; Neurons; Outcome; Parkinson Disease; Partner in relationship; Pathway interactions; Pattern; Photometry; Physiological; Play; Psychological reinforcement; Rewards; Role; Shelter facility; Signal Transduction; Source; Speed; Substantia nigra structure; Time; Training; Ventral Tegmental Area; Vertebrates; Water; Work; computer framework; dopaminergic neuron; experimental study; learned behavior; motor behavior; motor control; new technology; novel; optogenetics; pars compacta; phase change; relating to nervous system; response; restraint; statistics; virtual

Project abstract Animals explore their environment spontaneously in order to obtain food, water and shelter, as well as to find mates. Feedback from the environment, including the acquisition of rewards (such as those listed above) or avoiding aversive outcomes (such as encountering a predator), alters the future behavior of the animal. This form of learning and adaptation is essential to survival and, in vertebrates, is shaped by the basal ganglia and strongly influenced by neurons that make dopamine. Here we examine when dopamine neurons are active during free exploration and how that activity is influenced by the virtual acquisition of an expected reward, or a reward triggered by the execution of a specific motor action. We will compare the activity of two different sources of dopamine that have been differentially implicated in signaling reward and in executing motor actions. Lastly, we will examine how the activity of dopamine neurons regulates their downstream targets to sculpt on going and future motor action. Our results will be integrated into a computational framework that will be used to guide future research into motor control, dopamine signaling, and behavioral adaptation.

项目摘要 动物自发地探索其环境以获得食物、水和住所，以及寻找 伙伴们。来自环境的反馈，包括获得奖励（例如上面列出的）或 避免令人厌恶的结果（例如遇到捕食者）会改变动物未来的行为。这 学习和适应的形式对于生存至关重要，并且在脊椎动物中，由基底神经节和 受到产生多巴胺的神经元的强烈影响。在这里我们检查多巴胺神经元何时活跃 在自由探索期间，以及该活动如何受到预期奖励或虚拟获得的影响 由执行特定运动动作触发的奖励。我们将比较两个不同的活动 多巴胺的来源与信号奖励和执行运动有不同的关系 行动。最后，我们将研究多巴胺神经元的活动如何调节其下游靶点 塑造正在进行和未来的运动动作。我们的结果将被整合到一个计算框架中，该框架将 用于指导未来运动控制、多巴胺信号传导和行为适应的研究。