Career Enhancement Program

职业提升计划

• 批准号: 10456966
• 负责人: Stephen J Forman
• 金额: $ 12.31万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-02 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10456966
• 关键词: Acute Myelocytic Leukemia; Alabama; Award; Awareness; Biological Markers; Budgets; CD19 gene; Cell Therapy; Cities; Clinical; Cytomegalovirus; Direct Costs; Educational Activities; Ensure; Evaluation; Feedback; Funding; Human Resources; IL3RA gene; Individual; Investigation; Lead; Lymphoma; Malignant Neoplasms; Manuscripts; Mentors; Minority; NIH Program Announcements; Outcome; Patients; Process; Program Reviews; Progress Reports; Recommendation; Research; Research Institute; Research Personnel; Research Project Grants; Review Committee; Scientist; Specificity; Talents; Time; Training; Translational Research; Universities; Wages; Woman; Work; career; chimeric antigen receptor T cells; experience; innovation; investigator training; meetings; member; minority investigator; program costs; programs; recruit; senior faculty

The primary aim of the Career Enhancement Program (CEP) is to attract and train exceptional investigators at City of Hope and University of Alabama Birmingham in conducting outstanding lymphoma translational research. Both junior and established researchers who desire to focus or refocus on lymphoma may participate. Two individuals are supported every year, for up to two years. Recruitment of investigators who wish to pursue a career in lymphoma research may also take place. SPORE has budgeted direct costs of $50,000 per year, with additional yearly contributions from City of Hope and UAB of $100,000 and $25,000, respectively. Investigators can use funds for salary support for protected research time, personnel and supplies, and meeting and training expenses. Drs. Stephen Forman, Alexandra Levine, and Smita Bhatia, collectively representing extensive mentoring experience, lead the CEP. They will direct the process of selecting trainees, providing advice and feedback, and coordinating an annual review. Program announcements are widely disseminated through various media to ensure awareness. A sustained, concerted effort will be made to attract women and minority candidates. Applicants are reviewed on the basis of their qualifications, the scientific merit and feasibility of their proposed project, and the potential for meaningful interaction with the other projects and cores within the SPORE. Trainees are to select mentors among senior faculty or SPORE members; the Career Enhancement Committee must approve the choice and is available for assisting the matching process. Trainees submit a written progress report twice annually, detailing relevant work to date and manuscripts and presentations that arose from their research. Awardees present their research at the annual SPORE retreat. The External Advisory Board evaluates progress and seeks solutions to points of concern if necessary. Previous CEP recipients have been greatly productive. Dr. Xiuli Wang conducted highly promising research on chimeric antigen receptor (CAR) T cells redirected with dual specificity for cytomegalovirus and CD19; this investigation has been promoted to a full project within the current SPORE. Dr. Elizabeth Budde performed studies that led to a CAR T cell trial directed against CD123 in acute myeloid leukemia, and she is now the clinical lead in Project 4 of the SPORE. Dr. Alex Herrera, now a basic SPORE leader in Project 3, has made significant progress studying biomarkers and outcome in patients who undergo cellular therapies; two main translational research projects are ongoing. We anticipate that the new class of investigators will continue the tradition of performing cutting-edge, transformative lymphoma research.

职业提升计划 (CEP) 的主要目的是吸引和培训优秀的人才 希望之城和阿拉巴马大学伯明翰分校的研究人员进行了杰出的研究 淋巴瘤转化研究。渴望专注的初级和成熟研究人员 或重新关注淋巴瘤可能会参与。每年支持两个人，最多可达 两年。招募希望从事淋巴瘤研究职业的研究人员可能会 也发生。 SPORE 的直接成本预算为每年 50,000 美元，每年还有额外的费用 City of Hope 和 UAB 分别捐款 100,000 美元和 25,000 美元。调查员 可以使用资金为受保护的研究时间、人员和用品提供工资支持，并且 会议和培训费用。博士。史蒂芬·福尔曼、亚历山德拉·莱文和斯米塔·巴蒂亚， 共同代表丰富的指导经验，领导 CEP。他们将指导 选择受训者、提供建议和反馈以及协调年度培训的过程 审查。通过各种媒体广泛发布计划公告，以确保 意识。将做出持续、一致的努力来吸引妇女和少数族裔 候选人。申请人的审查依据是他们的资格、科学价值和 他们提出的项目的可行性，以及与其他人进行有意义的互动的潜力 SPORE 内的项目和核心。学员在高级教师或高级教师中选择导师 孢子会员；职业发展委员会必须批准该选择，并且 可用于协助匹配过程。学员两次提交书面进度报告 每年，详细介绍迄今为止的相关工作以及来自的手稿和演示文稿 他们的研究。获奖者在年度 SPORE 务虚会上展示他们的研究成果。外部 咨询委员会评估进展情况，并在必要时寻求关注点的解决方案。 以前的 CEP 接受者非常有成效。王秀丽博士给予高度评价 具有双重特异性的嵌合抗原受体 (CAR) T 细胞重定向研究前景广阔 针对巨细胞病毒和 CD19；这项调查已升级为一个完整的项目 当前的孢子。 Elizabeth Budde 博士进行的研究导致了针对 CAR T 细胞试验的研究 抗CD123治疗急性髓系白血病，她现在是该项目4的临床负责人 孢子。 Alex Herrera 博士现在是项目 3 的 SPORE 基本领导者，他取得了重大成就 接受细胞疗法的患者的生物标志物和结果研究进展；两个主要 转化研究项目正在进行中。我们预计新一类调查人员将 继续进行尖端、变革性淋巴瘤研究的传统。