Pathology and Bio-analytics Core

病理学和生物分析核心

基本信息

批准号：
10452735
负责人：
Sanjay Srivastava
金额：
$ 16.62万
依托单位：
UNIVERSITY OF LOUISVILLE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10452735
关键词：
Acetylcysteine Address Alkaloids Analytical Biochemistry Applications Grants Area Atherosclerosis Benzene Biological Assay Cardiovascular Diseases Cardiovascular Physiology Cardiovascular system Centers of Research Excellence Charge Chemicals Chromatography Clinical Chemistry Collaborations Communities Complete Blood Count Complications of Diabetes Mellitus Continuing Education Data Analyses Diabetes Mellitus Directed Molecular Evolution Educational workshop Ensure Equipment Evolution Experimental Designs Extramural Activities Faculty Fee-for-Service Plans Fostering Functional disorder Funding Future Glucose Goals Grant Hepatic Human Resources Infrastructure Kidney Lipids Maintenance Malondialdehyde Mass Chromatography Mass Fragmentography Mass Spectrum Analysis Measures Metabolic Molecular Weight Neurotransmitters Obesity Participant Pathologic Pathology Pathway Analysis Phase Pilot Projects Plasma Play Procedures Program Research Project Grants Protocols documentation Research Research Personnel Resolution Resources Role Science Scientist Services Specimen Stable Isotope Labeling Structure Superfund Technical Expertise Techniques Tobacco Training United States National Institutes of Health Universities Volatile Fatty Acids Work Xenobiotic Metabolism cost design detection method diabetic experience experimental study instrument interest investigator training knowledgebase mass spectrometer member metabolomics monoamine muconic acid non-diabetic novel operation oxidation ranpirnase research facility stable isotope symposium toxicant urinary vascular inflammation volatile organic compound webinar

项目摘要

Overarching goal of the Center is to understand the mechanisms of pathophysiology of diabetes and obesity and their cardiovascular complications. The Bioanalytics Core is an integral part of the Center and will play a key role in the evolution of COBRE in Phase III. The Core will render services for rigorous and comprehensive bioanalytical analysis of diabetic specimens. It will provide intellectual input with experimental design and state-of-the-art technical expertise to address the needs of Center investigators. The Core consists of a group of outstanding scientists with expertise in chromatography, mass spectrometry, clinical chemistry, cardiovascular physiology and diabetes. Director of the Core, Dr. Sanjay Srivastava has more than twenty five years of research experience in analytical biochemistry and pathology, vascular inflammation, atherosclerosis and diabetes. He will oversee all the Core operations and will work closely with Center investigators and COBRE-supported pilot project leaders to fulfill their analytical biochemistry needs. Dr. Lorkiewicz, technical director of the Core has extensive experience in stable isotope labeling and mass spectrometric analyses of small molecular weight compounds. He will assist the Center investigators with their metabolomics, mercapturomics and other chromatography/mass spectrometry analyses. Drs. Srivastava and Lorkiewicz will provide hands on training to junior investigators for bioanalytical assays. The training acquired at the Core will facilitate them to grow as scientists and expand their repertoire of technical skills. The Core is equipped with state-of-the-art clinical chemistry and analytical biochemistry equipment and is located in the Delia Baxter Building. In addition to address the current requirements of the COBRE projects, the Core will continue to expand its knowledgebase and technical expertise to satisfy the future needs of the Center. Long term goal of the Core is to become a fiscally independent entity capable of providing cutting-edge pathology and bio-analytical services to researchers interested in diabetes and cardiovascular pathophysiology. Continued excellence in pathological analyses will foster collaborations which will not only help the Core financially, but will also advance the field in combatting diabetic complications.

该中心的首要目标是了解糖尿病的病理生理学机制和肥胖及其心血管并发症。生物分析核心是生物分析的一个组成部分该中心将在 COBRE 第三阶段的发展中发挥关键作用。核心将渲染对糖尿病样本进行严格和全面的生物分析的服务。它将通过实验设计和最先进的技术专业知识提供智力投入满足中心调查人员的需求。核心由一批杰出科学家组成拥有色谱、质谱、临床化学、心血管方面的专业知识生理学和糖尿病。核心主任 Sanjay Srivastava 博士拥有超过 25 在分析生物化学和病理学、血管炎症、动脉粥样硬化和糖尿病。他将监督所有核心业务，并与中心研究人员和 COBRE 支持的试点项目负责人完成他们的分析生物化学的需要。核心技术总监Lorkiewicz博士在以下领域拥有丰富的经验：小分子量化合物的稳定同位素标记和质谱分析。他将协助中心研究人员进行代谢组学、巯基组学和其他研究色谱/质谱分析。博士。 Srivastava 和 Lorkiewicz 将提供帮助对初级研究人员进行生物分析检测培训。在核心获得的培训将促进他们成长为科学家并扩展他们的技术技能。核心是配备最先进的临床化学和分析生化设备，位于迪莉娅巴克斯特大厦。除了满足 COBRE 的当前要求外项目，核心将继续扩大其知识库和技术专长，以满足中心未来的需求。核心的长期目标是成为财政独立的国家能够为研究人员提供尖端病理学和生物分析服务的实体对糖尿病和心血管病理生理学感兴趣。病理学领域持续卓越分析将促进合作，这不仅可以在财务上帮助核心，而且还可以推进对抗糖尿病并发症的领域。